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Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

The performance of macroscopic graphene fibers is hampered by lower bonding strength between individual graphene sheets. Authors mitigate this by creating covalent conjugating linkages at sheet edges, improving mechanical and electrical properties.

Drug resistance is inevitable and pervasive. Here, the authors identify the V517F mutation as a significant contributor to USP7-mediated inhibitor resistance. This discovery offers valuable insights for the development of next-generation USP7 inhibitors.

Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.

This study identified two dirigent proteins responsible for the biosynthesis of the two enantiomers of gossypol in cotton. Editing one of the dirigent proteins selectively removed the toxic (−)-gossypol in cotton seeds without affecting pest resistance.

An analysis of 140 floras from China reveals that high species diversity exists in granite and mixed landforms, while low species diversity is found in karst, Danxia, and desert landforms. Based on these findings, the authors provide new clues for understanding the assembly and differentiation of mountain floras, highlighting the role of bedrock and landform processes.

Psoriasis is a skin disease associated with neurogenic inflammation. Here, the authors activation of ASIC3 on sensory neurons that leads to the release of CGRP, which triggers inflammation through dendritic cells and drives psoriatic inflammation.

Single photon devices are needed for many future technologies, but resolving the color of single photons in a compact architecture is still a challenge. The authors present a broadband, chip-scale spectrometer for measuring single photon wavelengths from 600 to 2000 nm with no moving parts.

A calcium-dependent protein kinase ZmCPK39 regulates quantitative resistance to multiple foliar diseases in maize through the ZmCPK39–ZmDi19–ZmPR10 immune module.

Upconversion nanoparticles, which convert lower-energy light into higher-energy light, have many potential applications including sensing and imaging. Here, Wen et al. review recent advances that have addressed concentration quenching and enabled increasingly bright nanoparticles, opening up their full potential.

Analysis of the group II intron ribonucleoprotein shows the molecular interactions involved in branchpoint adenosine recognition, lariat formation and exon ligation, providing clues to the evolutionary conservation of structural components and catalytic mechanisms in premessenger RNA splicing.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

A globally interconnected solar-wind power system can meet future electricity demand while lowering costs, enhancing resilience, and supporting a stable, sustainable transition to net-zero emissions.

Ye et al. find a positive causal effect of mental well-being on healthy aging, independent of socioeconomic status. This work underscores the imperative to prioritize mental well-being in health policies geared to fostering healthy aging.

In a randomized controlled trial involving patients with heart failure with reduced ejection fraction, treatment with Qiliqiangxin, a traditional Chinese medicine derived from 11 types of plants, decreased the incidence of cardiac events, as compared to placebo.

Hepatitis B infection is a risk factor for hepatocellular carcinoma. Here, the authors characterise viral infection in a cohort of hepatocellular carcinoma patients and find viral integration is more frequent in males than females.

Driving comfort in autonomous vehicles is crucial but often overlooked in global path planning. Here, authors developed a model using multi-head attention and XGBoost to predict driving comfort from road information, reducing jerk by 15% and improving comfort scores by 13% in real vehicle tests.

The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern and early assessment would be vital. Here, the authors show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical characteristics at admission.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Solitary fibrous tumours are mesenchymal tumours with an unpredictable progression and current medical treatments for relapsed SFTs remain ineffective. Here, the authors identified potential therapeutic targets and risk factors for SFTs and created an integrated risk model using 101 patients, and validated in 3 independent cohorts to successfully predict tumour progression.

The evolution and phylogenetic placement of gnetophytes have remained elusive. The draft genome for a gnetophyte, Gnetum montanum, is now reported. Comparative analyses identify genomic features distinguishing gnetophytes from other gymnosperms.

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

The CD47/SIRPα axis is well known to mediate immune escape by promoting cancer resistance to phagocytosis. Here the authors show that low CD47-expressing prostate cancer cells still allow phagocytosis but the process is incomplete leading to the formation of macrophage:tumor hybrid cells with immune evasive and pro-metastatic properties.

Yijun Ruan and colleagues report the draft genome of the sweet orange, Citrus sinensis. Their data suggests sweet orange originated from a cross between pummelo and mandarin.

N/O-Heterocycles are widely spread in natural products and drug candidates. Here, the authors report a modular access to bridged piperidine-γ-butyrolactones via Cu/Ir-catalyzed asymmetric allyation and aza-Prins cyclization/lactonization sequences.

Upregulation of GLI1 of has previously been reported in sonic hedgehog (SHH) driven medulloblastoma and basal cell carcinoma (BCC). Here, the authors find that SHH-inactivation of p38 results in stabilization of the transcription factor GLI1 via dephosphorylation at Ser937, resulting in expression of SHH genes and presenting a potential therapy strategy for medulloblastoma and BCC.

The mediators of bone-fat axis remain largely unknown. Here, the authors show SHN3 gene-deficiency in bone can protect mouse models from weight gain driven by diet-induced obesity through secreting a bone-derived cytokine, C-fragment of SLIT2, which could stimulate adipocyte browning.

Controlling magnetization orientation and assembling high-coercivity micro-magnets at the microscale has been challenging due to harsh operational requirements and limited spatial precision. The authors present a stretchable linear magnet with programmable magnetization enabled by laser-activated phase-change microcells, achieving efficient and reversible reorientation under mild conditions.

Controlled synthesis of supramolecular structures within lysosomes holds promise for cancer imaging and treatment. The authors introduce a programmable assembly strategy to generate fluorescent nanofibres in tumour cell lysosomes, enabling targeted tumour accumulation and inducing pyroptosis for precise cancer imaging and immunotherapy.

Characterising the tumour microenvironment features of lung adenocarcinoma (LUAD) remains crucial. Here, the authors perform single cell RNA sequencing data analysis of 117 LUAD samples and functional assays and highlight the immunosuppressive role of UPP1high tumour cells.

Membranes tailored for selective ion transport represent a promising avenue toward enhancing sustainability across various fields but limited interaction between ions and nanochannels in polymers of intrinsic microporosity hinders their effectiveness. Here, the authors introduce the randomly twisted V-shaped structure of Tröger’s Base unit and quaternary ammonium groups to construct ionized sub-nanochannel membranes and demonstrate the enhanced transport of the dehydrated monovalent ions.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Qiang Xu and colleagues sequence four citrus species de novo, along with 100 accessions, including primitive, wild and cultivated citrus. Their genomic analyses associate the CitRWP gene with polyembryony and suggest that regions harboring energy- and reproduction-associated genes are probably under selection in cultivated citrus.

A deep learning model provides high accuracy in detecting pancreatic lesions in multicenter data, outperforming radiology specialists.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

The molecular mechanisms underlying metabolic remodelling in colorectal cancer (CRC) are not completely elucidated. Here, they authors show that the oncogenic protein MYG1 promotes CRC progression not only through regulating mitochondrial activity, but also through activating a nuclear-associated pathway for glycolysis increase.