The authors report that MeCP2, a methyl DNA–binding transcriptional regulator, modulates the response to amphetamine in the nucleus accumbens. Using both acute viral manipulation of MeCP2 in mice and hypomorphic Mecp2 mutant mice, they find that MeCp2 both affects mesolimbocortical circuit development and regulates the responses to psychostimulants.
- Jie V Deng
- Ramona M Rodriguiz
- Anne E West
