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A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

The mitochondrial pathway of apoptosis requires coordinated protein–lipid signals. Here, Gelles et al. show that a BAX lipid-binding cavity for 2-trans-hexadecenal cooperates with BIM to allosterically activate BAX prior to membrane insertion.

Superoscillations enable waves to oscillate faster beyond classical limits. Here, the authors demonstrate simultaneous spatial and temporal superoscillations in structured light pulses, achieving extreme both subwavelength and ultrafast focusing in space-time.

Many GPCRs signal from endosomes, which requires active G proteins at this location. Here, the authors describe how active Gα_s accumulates on endosomes and reveal location-biased selectivity in GPCR-mediated G protein activation.

METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors identify a noncoding regulatory region at the Fgf9 locus and reveal that Meis genes are key regulators of sexual differentiation.

Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models.

Here the authors combine clinical and metabolomics data to identify distinct metabotypes of pediatric metabolic dysfunction-associated steatotic liver disease (MASLD). The results provide information regarding heterogeneity of MASLD presentation, but require validation in independent cohorts.

The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

Meningiomas are common brain tumors with variable behavior. This study reveals high STING expression across multiple cell types in the meningioma microenvironment. STING agonism triggers tumor cell death via programmed necrosis and pyroptosis, enhancing survival in preclinical models.

DNA methylation heterogeneity and dynamics hinder distinguishing early pathological changes from normal variation. Here, the authors identify stable sites whose disruption is linked to blood cancers, aging, and cardiovascular risk.

A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial development.

Neoantigen-based adoptive T cell therapies represent a personalized approach for cancer immunotherapy. Here the authors describe NEO-STIM, an ex vivo T cell induction platform to STIMulate peripheral blood T cells to generate responses against tumor NEOantigens.

Pico-C, a low-input Micro-C approach, reveals that dynamic three-dimensional genome folding precedes zygotic genome activation in Drosophila.

In this work, authors provide evidence that bacteria in spatially structured populations protect each other from antibiotics through collective nutrient consumption, creating ‘death fronts’ that sweep through the colony– explaining why infections often survive treatments that work in lab tests.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their progenitors in the bone marrow.

While the benefits of crop diversity are known, doubts remain as to whether replacing cereals in rotations reduces nutrient production. A comparison of 16 long-term field experiments across Europe shows no trade-off between functionally rich rotations and food productivity.

The severity of climate change impacts calls for low-carbon thermal management solutions. This work presents a chameleon-inspired electronic skin for adaptive electrochromic thermal regulation with minimal energy input and scalability potential.

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Therapies combining chemotherapy and immune checkpoint inhibitors have shown limited efficacy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). Here the authors report the results of a pilot phase 1 trial of neoadjuvant modified Folfirinox plus nivolumab in borderline-resectable PDAC, including safety, efficacy and immunological correlates.

A new platform making use of hexagonal boron nitride interfaced with the molecular superconductor κ-(BEDT-TTF)₂Cu[N(CN)₂]Br is demonstrated for realizing cavity-altered materials, confirmed by magnetic force microscopy and nano-optical measurements.

The authors reveal how the intrinsically disordered oncoprotein N-Myc dynamically interacts with Aurora kinase A in an inhibitable binding mode that allosterically promotes its activation, offering opportunities to restrict neuroendocrine tumor growth.

Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D genome organization, gene expression and cell fate determination.

The vacuum process is scalable and solvent free, yet all-vacuum-deposited perovskite solar cells still trail solution-processed counterparts. Facet-directed co-evaporation yields (100)-oriented mixed-halide wide-bandgap films for efficient, stable single-junction cells and perovskite–silicon tandem cells.

Chromosome folding in early zebrafish development starts with formation of fountains. These patterns, also prominent in other systems, form at active enhancers, depend on transcription factors, and reflect preferential loading of loop extruding cohesin at enhancers.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

MsbA mediates the transport of lipopolysaccharide across the inner membrane. Here, the authors show specific MsbA-lipid interactions can tune the selectivity for binding ATP over ADP and present five structures of MsbA with one bound to lipid.

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

Enzymes adapt by sampling new conformations while balancing destabilizing effects of mutations. Here, the authors reveal how TEM-1 β-lactamase acquires cefotaxime resistance through reshaping of dynamic conformational ensembles and localized stability networks, offering insight into the molecular framework of the activity-stability tradeoff.

Acute depletion of NIPBL reveals a class of chromatin loops that are independent of NIPBL for their maintenance but not their establishment and that NIPBL is necessary for the expression of lineage-defining genes.

Stepp and colleagues present hybrid-EDA, an event-driven acquisition (EDA) that enables gentle investigation of rare mitochondrial events. This approach combines continuous, low-phototoxicity phase-contrast surveillance with event-triggered fluorescence imaging, powered by dynamics-aware machine-learning event detection.

This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein production and stops phage replication.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Non-equilibrium two-dimensional melting is less understood than its equilibrium counterpart. Now it is shown that topologically driven melting in a two-dimensional crystal of charged colloids is the same irrespective of the mechanisms that generate the defects

Accurate determination of population size for highly-mobile marine animals is often prohibitively difficult. Here, Bravingtonet al.estimate the abundance of southern bluefin tuna using a method based on the number of parent-offspring pairs detected genetically in samples from the catch.

Crystalline materials for optical applications are synthesized in living dinoflagellates.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

Soft electrostatic actuators are crucial for advancing robotic systems that require adaptability and safety in unstructured environments. This study introduces ultralight soft electrostatic actuators utilizing solid-liquid-gas architectures, achieving significant improvements in power-to-weight ratio and actuation speed, exemplified by a 60% increase in jump height in a jumping robot compared to traditional designs.