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Surface structures can have an important effect on the traits of two-dimensional electron liquids. Here, the authors demonstrate how the surface terminations of SrTiO₃(001) affect the mechanism and properties of the two-dimensional electron liquid.

Here the authors identify PHF3 SPOC domain as a reader of the phosphorylated RNA polymerase II (Pol II) C-terminal domain. They show that PHF3 clusters with Pol II complexes in cells, drives phase separation of Pol II in vitro, and regulates neuronal gene expression and neuronal differentiation.

Passive immunisation for respiratory syncytial virus for infants is recommended by the World Health Organization but products currently available have limited duration of protection. Here, the authors investigate the age distribution of infant hospitalisation for respiratory syncytial virus to inform optimal timing of immunisation.

Single-cell RNA and assay for transposase-accessible chromatin sequencing in isogenic prostate adenocarcinoma cells undergoing neuroendocrine transition identify dynamic changes in chromatin and transcriptomic states coregulated by NKX2-1, FOXA2 and p300/CBP.

Despite its impressive mechanical and electronic properties, graphene’s magnetic characteristics are poor. However, adsorbed organic molecules can give the material magnetic functionality, and the magnetic moment remains when the molecules combine to form dimers or even a continuous monolayer.

A distribution in fin widths, due to variability in the fabrication process, can be used to study a latching condition in gallium nitride transistors in which drain current sharply transits from an off-state value to a high on-state value with a slope of less than 60 mV per decade.

A nanoscale superconducting sensor used to map the magnetic fringe fields in twisted bilayers of MoTe₂ shows the formation of fractional Chern insulator states at zero magnetic field.

A pulse of ocean acidification is reconstructed from the boron isotope composition of fossilized oysters at the Triassic-Jurassic boundary, implicating ocean acidification from volcanic outgassing as a kill mechanism during the extinction event.

Scintillators are used for converting X-ray energy into visible light in imaging technologies. Here, the authors present a scalable fabrication approach for large-area nanostructured scintillators, and achieve six-fold enhancement in light yield compared to unpatterned scintillators.

Ataxia telangiectasia and Rad3-related kinase (ATR) is a rational radiosensitization target. This trial evaluates the combination of the ATR inhibitor, ceralasertib, with palliative radiotherapy in 27 patients with advanced solid tumors.

Efficient hydrogen production is a major societal challenge. Here the authors use operando neutron diffraction to quantitatively support the operating principle of a memory reactor that allows super-equilibrium operation of the water–gas shift reaction, which can also be used for steam methane reforming.

This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic target.

Ilievski et al. examine differences and similarities in the various ways human and AI systems generalize. The insights are important for effectively supporting alignment in human–AI teams.

Epithelial sealing is a fundamental process in animal development and wound healing. Here the authors show that a transient contractile seam in the freshly sealed epidermis generates forces promoting tissue zippering during Drosophila dorsal closure.

Glycans are structurally complex biomolecules and very challenging to analyse. Here the authors show atomically resolved imaging of β-cyclodextrins with non-contact atomic force microscopy, revealing the structure of individual glycans with atomic detail.

This study demonstrates that high alcohol concentrations during binge drinking activate a small GABAergic neuronal ensemble in the medial orbitofrontal cortex, which subsequently reduces further alcohol consumption. This effect is mediated by the ensemble’s projections to the mediodorsal thalamus.

Here, the authors use atomic force microscopy under ultra-high vacuum conditions to study intramolecular single electron transfer within a single molecule. This allows them to investigate energy dissipation process related to the electron transfer as a function of temperature.

The effects of climate change on the yield and aroma of beer hops remains unknown. Here the authors demonstrate a climate-induced decline in the quality and quantity of traditional aroma hops across Europe and calls for urgent adaptation measures to stabilize international market chains.

The SiO₂ contents of erupted volcanic melts are correlated with persistent seismic signals that accompany eruptions—volcanic tremor—and may represent an eruption monitoring tool, according to a study of volcanic ash glasses from Cumbre Vieja volcano.

Atomic force microscopy is capable of resolving the chemical structure of a single molecule on a surface, usually at low temperatures. Here, the authors demonstrate that the chemical structure of a single molecule strongly adsorbed onto a silicon surface can be determined at room temperature.

The Paleogene continental collision between the Indian subcontinent and Asia initiated biotic interchange over a timescale of millions of years. Klaus et al. develop a phylogeographic method to estimate the dynamics of biotic interchange over these timescales, revealing periods of acceleration, stagnation and decline.

Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity and identified potential therapeutic targets.

Veselago lensing is the focussing of a diverging beam upon entering a medium with negative refractive index. Using a bichromatic optical lattice potential, Leder et al.create a relativistic dispersion relation for cold rubidium atoms that allows them to demonstrate Veselago lensing for matter waves.

Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in both iST and live imaging experiments.

The dimensionality of a many-body system strongly impacts its physical behaviour. Now, a crossover from 1D to 2D has been observed in the Bose–Einstein condensate of a photon gas.

Moreno-Loaiza et al. found that interleukin-1β, acting upon cardiac resident macrophages, promotes atrial fibrillation in mice, and this mechanism may represent a common pathway connecting various risk factors to this arrhythmia.

The epigenetic mechanisms underlying phenotypic diversity across different metastatic sites in castration-resistant prostate cancer (CRPC) remain to be characterised. Here, multi-omic profiling across metastatic lesions identifies regulatory networks driving tumour lineage programs and potential therapeutic targets.

Structural elucidation of the RAG strand transfer complex reveals how the recombinase efficiently catalyzes both forward and reverse integration reactions to prevent RAG-mediated transposition events.

The ‘boson peak’ refers to an extra peak in the terahertz vibrational spectrum of glasses. It is now shown that for liquids of highly symmetric molecules the boson peak can be singled out by means of depolarized Raman scattering; the peak is linked to the formation of clusters of about 20 molecules.