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Scientific Reports (13)
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Showing 1–50 of 53 results

Advanced filters: Author: Masatoshi Hashimoto Clear advanced filters

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Lymphoma risk in autoimmune diseases with multiple medication use: analysis from the LIFE Study

Ami Inokuchi
Haryoon Kim
Keisuke Kataoka
ResearchOpen Access02 Dec 2025
Blood Cancer Journal

Volume: 16, P: 1-10
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Genetic structure of human populations I. Local differentiation of blood group gene frequencies in Japan

Masatoshi Nei
Yoko Imaizumi
Research01 Feb 1966
Heredity

Volume: 21, P: 9-35
The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025)

Yusuke Ohya
Kimika Arakawa
Atsushi Sakima
Reviews01 Jan 2026
Hypertension Research

Volume: 49, P: 9-235
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Liver steatosis and errors in estimation of standard liver volume

Accurate estimation of standard liver volume (SLV) is one of the key factors for successful liver transplantation. Contrary to some misconceptions, SLV was developed for the sake of the recipient and not for the donor in living donor liver transplantation. A recent study evaluated the accuracy of five formulas for estimation of SLV, and investigated the effect of liver steatosis on errors in estimation.

Takuya Hashimoto
Masatoshi Makuuchi
News & Views15 Nov 2011
Nature Reviews Gastroenterology & Hepatology

Volume: 8, P: 667-668
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Side-Chain Liquid Crystalline Block Copolymers with Well Defined Structures Prepared by Living Anionic Polymerization IV. Microphase Morphology in Blends with Coil Homopolystyrenes

Tomomichi Itoh
Naoki Tomikawa
Junji Watanabe
Research01 Oct 2001
Polymer Journal

Volume: 33, P: 783-791
Correction: Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
Amendments and CorrectionsOpen Access20 Apr 2016
Nature Communications

Volume: 7, P: 1
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
De novo designed YK peptides forming reversible amyloid for synthetic protein condensates in mammalian cells

Protein condensates underlie various cellular events. Here, the authors developed short peptide tags that form reversible amyloids, which enable the fabrication of artificial protein condensates with different fluidities or multi-component properties in mammalian cells.

Takayuki Miki
Masahiro Hashimoto
Hisakazu Mihara
ResearchOpen Access18 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice.

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-17
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Artificial Membranes from Multiblock Copolymer IV. Four-Component Pentablock Copolymers of the DSD′AD Type Usable to Fabricate a Charge-Mosaic Membrane

Shin-ichi Takahashi
Kosaburo Matsumura
Yoshiyuki Miyaki
Research01 Jan 1986
Polymer Journal

Volume: 18, P: 41-49
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip

Strict examinations have resulted in drastically shortened life spans for a broad range of biotech 'pioneer' patents in Japan.

Tomomi Aida
Atsuo Konishi
Kazunori Hashimoto
Comments & Opinion01 May 2007
Nature Biotechnology

Volume: 25, P: 533-535
Associations of Brachial-Ankle Pulse Wave Velocity and Carotid Atherosclerotic Lesions with Silent Cerebral Lesions

Masatoshi Matsumoto
Kazuo Inoue
Akihito Moriki
Research01 Sept 2007
Hypertension Research

Volume: 30, P: 767-773
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
New generative methods for single-cell transcriptome data in bulk RNA sequence deconvolution

Toui Nishikawa
Masatoshi Lee
Masataka Amau
ResearchOpen Access20 Feb 2024
Scientific Reports

Volume: 14, P: 1-11
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children’s study

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
Research21 Jan 2019
Hypertension Research

Volume: 42, P: 558-566
Gaze behaviors during free viewing revealed differences in visual salience processing across four major psychiatric disorders: a mega-analysis study of 1012 individuals

Kenichiro Miura
Masatoshi Yoshida
Ryota Hashimoto
ResearchOpen Access11 Oct 2024
Molecular Psychiatry

Volume: 30, P: 1594-1600
Highly Asymmetric-selective and Stereoselective Polymerization of (RS)-α-Methylbenzyl Methacrylate with Cyclohexyl-magnesium Bromide-Axially Dissymmetric 2,2′-Diamino-6,6′-dimethylbiphenyl System

Shigeyoshi Kanoh
Sakae Goka
Hiroshi Suda
Research01 Sept 1987
Polymer Journal

Volume: 19, P: 1047-1065
Evidence for Shared Genetic Risk Between Methamphetamine-Induced Psychosis and Schizophrenia

Masashi Ikeda
Yuko Okahisa
Nakao Iwata
Research12 Apr 2013
Neuropsychopharmacology

Volume: 38, P: 1864-1870
A two-stage case–control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

Takayoshi Koide
Branko Aleksic
Norio Ozaki
Research23 Apr 2010
Journal of Human Genetics

Volume: 55, P: 469-472
Three-dimensional analyses of spherulite morphology in poly(oxyethylene) and its blends with amorphous poly(d,l-lactic acid) using X-ray computerized tomography

Three-dimensional structural analyses of huge spherulites of poly(oxyethylene) (PEG) using X-ray computerized tomography (CT) in blends of PEG and amorphous poly(d,l-lactic acid) are reported for the first time. Slit-shaped cracks that were straight or curved were clearly observed using X-ray CT. Furthermore, they appeared to form a set of spokes, presenting a signature of a huge spherulite. Several aspects that are representative of an axialite structure are presented, and they are in good agreement with the intuitively proposed structural model for axialite long ago, although the size scale is much larger in our study.

Nguyen-Dung Tien
Yukihiro Nishikawa
Shinichi Sakurai
Research19 Nov 2014
Polymer Journal

Volume: 47, P: 37-44
Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia

Hidenaga Yamamori
Ryota Hashimoto
Masatoshi Takeda
Research21 Apr 2011
Journal of Human Genetics

Volume: 56, P: 478-483
Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

Yukiya Sako
Kensuke Ninomiya
Masatoshi Hagiwara
ResearchOpen Access30 May 2017
Scientific Reports

Volume: 7, P: 1-9
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-ε4 carriers

Nuripa Jenishbekovna Aidaralieva
Kouzin Kamino
Masatoshi Takeda
Research01 Apr 2008
Journal of Human Genetics

Volume: 53, P: 296-302
Expression of CD109 in human cancer

Mizuo Hashimoto
Masatoshi Ichihara
Masahide Takahashi
Research29 Apr 2004
Oncogene

Volume: 23, P: 3716-3720
Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae

Takuya Suga
Yukihiro Asami
Kazuro Shiomi
Research06 May 2015
The Journal of Antibiotics

Volume: 68, P: 649-652
Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO₂ nanofiber filter

Takeki Yamamoto
Muneaki Hashimoto
Toshihiro Mita
ResearchOpen Access20 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Visual salience is affected in participants with schizophrenia during free-viewing

Masatoshi Yoshida
Kenichiro Miura
Ryota Hashimoto
ResearchOpen Access26 Feb 2024
Scientific Reports

Volume: 14, P: 1-12
Retraction Note: A significant causal association between C-reactive protein levels and schizophrenia

Masatoshi Inoshita
Shusuke Numata
Tetsuro Ohmori
Amendments and CorrectionsOpen Access21 Feb 2018
Scientific Reports

Volume: 8, P: 1
Two-Year Follow-Up of Vascular Events in Peripheral Arterial Disease Treated With Antiplatelet Agents: A Prospective Observational Multicenter Cohort Study (SEASON)

Yukihito Higashi
Tetsuro Miyata
Hideto Awano
ResearchOpen Access21 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia

Ken-ichi Okada
Kenichiro Miura
Ryota Hashimoto
ResearchOpen Access05 Feb 2021
Scientific Reports

Volume: 11, P: 1-12
Tumor necroptosis is correlated with a favorable immune cell signature and programmed death-ligand 1 expression in cholangiocarcinoma

Thanpisit Lomphithak
Perawatt Akara-amornthum
Siriporn Jitkaew
ResearchOpen Access03 Jun 2021
Scientific Reports

Volume: 11, P: 1-18
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses

Ryota Hashimoto
Kazutaka Ohi
Masatoshi Takeda
ResearchOpen Access18 May 2011
Neuropsychopharmacology

Volume: 36, P: 1921-1931
Substitution of Thr572 to Ala in mouse c-Myb attenuates progression of early erythroid differentiation

Kyoko Kitagawa
Chiharu Uchida
Masatoshi Kitagawa
ResearchOpen Access01 Sept 2020
Scientific Reports

Volume: 10, P: 1-11
A significant causal association between C-reactive protein levels and schizophrenia

Masatoshi Inoshita
Shusuke Numata
Tetsuro Ohmori
ResearchOpen Access19 May 2016
Scientific Reports

Volume: 6, P: 1-8
Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children’s Study

The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4–7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
ResearchOpen Access03 Feb 2023
Hypertension Research

Volume: 46, P: 834-844
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Brain Rewarding Stimulation Reduces Extracellular Glutamate Through Glial Modulation in Medial Prefrontal Cortex of Rats

Gen Murakami
Masato Nakamura
Daiichiro Nakahara
Research29 Apr 2015
Neuropsychopharmacology

Volume: 40, P: 2686-2695
Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder

Ryota Hashimoto
Takanobu Nakazawa
Hitoshi Hashimoto
ResearchOpen Access19 Nov 2015
Journal of Human Genetics

Volume: 61, P: 199-206
Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study

Noriyuki Iwama
Hirohito Metoki
Nobuo Yaegashi
Research07 Nov 2018
Hypertension Research

Volume: 42, P: 85-94
Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study

Noriyuki Iwama
Mari S. Oba
Hirohito Metoki
Research10 Mar 2020
Hypertension Research

Volume: 43, P: 550-559

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