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The 300–1,000 Hz band of spiking activity, dominated by local single-unit spikes, can enhance the decoding performance of neural interfaces.

Flexible superblack materials are crucial for minimizing stray light, complicating object identification, and serving as low reflectance standards, however it is challenging due to scalability and durability issues. Here the authors show a superblack material which is scalable, durable and flexible.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

Brain slices offer an experimental window into human neurophysiology. Using high-density microelectrode array recordings and adeno-associated virus–mediated optogenetics, the authors demonstrate that optogenetic targeting of CAMK2A+ neurons can affect network activity in human hippocampal slices.

The authors assess the growing field of climate change health impact attribution. They show literature bias towards direct heat effects and extreme weather in high-income countries, highlighting the lack of global representation in current efforts.

Massively parallel sequencing is a precise way to analyze copy-number variations given the right computational tools. An algorithm now facilitates the detection and fine mapping of copy-number gains and losses from millions of short sequence reads.

Tilting planar photovoltaic panels to track the position of the sun over the day can add to yearly energy consumption. Here, Lamoureaux et al.propose a kirigami solar cell structure with solar tracking integrated within the design, reducing cost, structural weight and bulk associated with conventional tracking.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

A ring-cavity quantum cascade laser is demonstrated to generate soliton microcombs in the mid-infrared regime.

An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8⁺ T cell activation.

Homogeneous Pt-group metal-based complexes make up the majority of C-H bond activation catalysts, but they are characterized by high cost and low abundance. Here, the authors report atomically dispersed titanium-aluminum-boron nanopowder for low-temperature catalytic activation of aliphatic C-H bonds via the element-specific cooperative mechanistic roles.

Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts.

Intuitive thermal perceptions during cold-object grasping with a prosthesis can be restored in a phantom hand through targeted nerve stimulation via a wearable thin-film thermoelectric device with high cooling power density and speed.

In this work, authors develop obex inhibitors that target a distinct binding pocket in the ATPase domain of Topoisomerase II. They demonstrate how Topobexin, a Topoisomerase IIβ - selective catalytic inhibitor, blocks conformational changes and protects against anthracycline cardiotoxicity.

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Adaptive optics (AO) corrects eye aberrations for sharp imaging, but their dynamics in clinical scenarios are much higher than expected. Ultrafast AO improves aberration correction and retinal imaging performance in these cases.

The WHO’s designation of mpox as a public health emergency of international concern underscores the need for diagnostics to combat this escalating threat. Here, the authors present a portable POC molecular platform based on power-free DNA extraction and colourimetric LAMP.

Clarke et al. presents a framework for spatial analysis of the metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging. Applying this approach, they revealed region-specific metabolic diversity and dysregulation in both normal and diseased mouse brains.

Healthcare innovation greatly benefits from the proactive inclusion of patients. Here we outline the importance of patients as co-creators of healthcare technology, providing insight into patient community engagement and resources for inclusion of the public and patients.

Brillouin interactions between sound and light can excite mechanical resonances in photonic microsystems, with potential for sensing and frequency reference applications. The authors demonstrate experimental excitation of mechanical resonances ranging from 49 to 1,400 MHz using forward Brillouin scattering.

All-optical coherent control schemes offer well-localized and ultrafast control of individual qubits in many-qubit systems. Here the authors report on all-optical resonant and Raman-based control of single silicon vacancies using picosecond pulses, much faster than the ground state coherence time.

Broadband light antireflection materials have numerous applications as highly transparent window, for broadband applications thin-film multilayers have been considered. Here, Rahman et al. demonstrate broadband antireflection enhancement in silicon solar cells using a self-assembled, nanostructured copolymer.

Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.

A chip-integrated laser with 7.5 × 10⁻¹⁴ fractional frequency instability is demonstrated by active stabilization to an on-chip 6.1-m-long spiral resonator. By using this laser to interrogate the narrow-linewidth transition of ⁸⁸Sr⁺, a clock instability averaging down as \(3.9\times 1{0}^{-14}/\sqrt{\tau }\) is achieved.

Single-cell analysis of patient brains and cortical organoids links disrupted developmental metabolic reprogramming to postnatal synaptic dysfunction in dup15q syndrome, revealing shared neuronal changes with idiopathic autism.

Here, authors use NeuroPainting, a high-content imaging assay, to reveal cell-type-specific effects of 22q11.2 deletion in neural cells, linking adhesion gene dysregulation to mitochondrial and structural abnormalities, especially in astrocytes.

The goal of the 1000 Genomes Project is to provide in-depth information on variation in human genome sequences. In the pilot phase reported here, different strategies for genome-wide sequencing, using high-throughput sequencing platforms, were developed and compared. The resulting data set includes more than 95% of the currently accessible variants found in any individual, and can be used to inform association and functional studies.

Here the authors develop MAJIQ v2 to address challenges in detection, quantification, and visualization of RNA splicing variations from large heterogeneous RNA-Seq datasets. They then apply it to analyze 2,335 samples from 13 brain subregions.

Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells

Self-ordered heterogeneous nanostructures are of broad interest for both fundamental studies and technological applications. Here authors show that segregation in a multicomponent system during growth can yield highly strained germanium nanowire arrays embedded within a ternary semiconductor matrix.

The efficiency of coherent transport can be enhanced through interaction between the system and a noisy environment. Here, Biggerstaff et al. report an experimental simulation of environment assisted coherent transport using laser-written waveguides, showing that controllable decoherence yields an increase in transport efficiency.

Psoriasis is a partially heritable skin disorder, the genetic basis of which is not fully understood. Here, the authors use genome-wide association meta-analysis to discover psoriasis susceptibility loci and genes, which encode existing and potential new drug targets.

The spectrally narrow photoluminescence lines occurring in transition metal dichalcogenides (TMD) heterostructures at low temperature have been attributed to interlayer excitons (IXs) localized by the moiré potential between the TMD layers. Here, the authors show that these lines are present even when the moiré potential is suppressed by inserting an hBN spacer between the TMD layers.

In this phase 1/2 trial, the authors show that INO-3107, a DNA immunotherapy designed to elicit an immune response against HPV-6 and -11 recurrent respiratory papillomatosis, is well-tolerated and demonstrates an antigen specific immune response resulting in surgical reduction in 81% of trial participants.

A photonic processor capable of running advanced artificial intelligence models with near-electronic precision is introduced, marking a substantial step towards post-transistor computing technologies.

Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell carcinoma tumors. They identify novel significantly mutated genes and amplification peaks and find that around half of the tumors have at least five predicted neoepitopes.

Global energy budgets of planets are important to understand their climate system. Here, the authors show long-term multi-instrument observations from Cassini spacecraft, which reveals dynamical imbalances of Saturn’s global energy budget.

Reforestation is a key climate change mitigation strategy, but global maps of its potential are widely criticized. This study shows that addressing those critiques substantially refines estimates of the places with reforestation potential.

Although rigid silicon panels dominate the solar power market, they are unsuitable for niche applications such as portable charging or drones, where thin-film and flexible technologies would be advantageous. This Analysis examines the needs of niche markets and the packaging weights that would be required to enable such photovoltaic devices to enter them.

Genome-wide analyses identify variants associated with sinus node dysfunction, distal conduction disease and pacemaker implantation, implicating ion channel function, cardiac developmental programs and sarcomeric structure in bradyarrhythmia susceptibility.

The alarming growth of the antibiotic-resistant superbugs has created a demand for sensors that can investigate antibiotics and their modes of action. The label-free detection of the antibiotic vancomycin binding to mucopeptides on cantilever arrays, with 10 nM sensitivity and at clinically relevant concentrations in blood serum, could lead to improved biosensors and a better understanding of antibiotic drug action in bacteria.

A genomic constraint map for the human genome constructed using data from 76,156 human genomes from the Genome Aggregation Database shows that non-coding constrained regions are enriched for regulatory elements and variants associated with complex diseases and traits.

The use of a chromium oxide interlayer separating the perovskite film from the metal contacts improves the stability of perovskite solar cells in air. Deposited on thin plastic foils, these ultralight devices power model airplanes and dirigibles.

Rapid extracellular antibody profiling reveals a contribution of autoantibodies to the effectiveness of checkpoint immunotherapy for cancer.

This study explores the impact of mood and individual differences on trading off between possible rewards and checking for the presence for threat and escaping to safety in a gamified foraging task.