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Freestanding membranes of hafnium zirconium oxide can be created using pulsed laser deposition method and used as the top-gate dielectric in molybdenum disulfide transistors.

Using whole-embryo imaging and point cloud analysis, Brambach et al. reveal that global tissue diversity can be reduced to two organisational archetypes, crystalline and amorphous, each requiring specific cadherin expression during development.

CellSpectra identifies functionally relevant changes in cellular pathways when analyzing single samples in comparison to a reference atlas, here applied to rodent models and patient samples of kidney disease.

Magnetized plasmas display continuous spectra of current-sheet equilibria. How they select a particular equilibrium is not well understood. Now, equilibrium selection in magnetized plasmas is studied by analytical theory, particle-in-cell simulations and spacecraft observations, highlighting the role of current-sheet relaxation processes.

Synthetic receptors are a powerful approach for engineering cell-based therapies that can sense and respond to their environment. Here cytokine receptor domains have been repurposed to develop engineered T cells that can sense and respond to cues associated with cancer or immune dysfunction.

Fusobacterium nucleatum promotes colorectal cancer via its adhesin Fap2. Here, Schöpf et al. show the molecular basis for Fap2 interaction with its receptors TIGIT on immune cells and Gal-GalNAc on tumor cells using cryo-EM and integrative modeling.

WHaloCaMP is a chemigenetic calcium indicator that can be combined with different rhodamine dyes for multiplexed or FLIM imaging in vivo, as demonstrated for calcium imaging in neuronal cultures, brain slices, Drosophila, zebrafish larvae and the mouse brain.

Membrane lipid packing, influenced by cholesterol, lipid chain length, and saturation, regulates the affinity of biomolecular condensates, enhancing their interactions with less ordered membranes and driving membrane remodeling, including nanotube and double-membrane sheet formation.

Self-intercalated Chromium tellurides consist of CrTe₂ van der Waals layers, with additional Chromium atoms residing in the van der Waals gap. This highly tuneable class of magnetic materials has presented a range of unique magnetic phenomena, and here Bigi, Jego, Polewczyk et al add to this by showing that CrTe₂ (δ = 0.25 − 0.50) hosts orthogonal ferromagnetism.

By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been resolved at a spatial resolution of 9 ångström.

Terahertz radiation is used to directly probe magnetotransport in metallic multilayers on the timescale of electron momentum scattering—the fundamental conditions of Nevill Mott’s model of spin-dependent conduction in metals.

2D materials have attracted significant attention for memristor applications, but a complete understanding of the switching mechanisms is still lacking. Here, the authors report an operando electron microscopy study of lateral MoS₂ memristors, showing real-time imaging of the dynamics of Ag conductive filaments during bias voltage cycles.

The spin texture of a magnetic system can host a variety of topological spin textures, the most famous of these being skyrmions. Here, Volkov et al demonstrate higher order vorticity in magnetic wireframe nanostructures and introduce a general protocol for the creation of arbitrary numbers of vortices and antivortices in such wireframe structures.

This study reports clusters of ipsilateral eye preferring neurons in layer 4 of mouse visual cortex, extending into layer 2/3 and upper layer 5. This column-like pattern for ocular dominance expands our understanding of the functional organization in neocortex.

Equivariant neural networks are state-of-the-art for machine learning-driven molecular dynamics (MD) simulations but have high computational cost. Here, the authors develop a Euclidean transformer that balances accuracy, stability, and speed, enabling stable long-timescale simulations of complex molecules

Here, a combination of forward genetics and genome-wide association analyses has been used to show that variation at a single genetic locus in Arabidopsis thaliana underlies phenotypic variation in vegetative growth as well as resistance to infection. The strong enhancement of resistance mediated by one of the alleles at this locus explains the allele's persistence in natural populations throughout the world, even though it drastically reduces the production of new leaves.

Beyond its known role in stabilizing microtubules, it is now shown that tau protein actively promotes lattice defect repair by enhancing tubulin turnover at topological defects.

The synthesis of crystalline 2D polymers typically relies on reversible dynamic covalent reactions, but achieving 2D polymers through irreversible carbon-carbon coupling reactions remains a formidable challenge. Here, the authors present an on-liquid surface synthesis method for constructing diyne-linked 2D polymers.

A study demonstrates how experimental measurements of only the connectivity of a biological neural network can be used to predict neural responses across the fly visual system at single-neuron resolution using deep learning techniques.

KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus contains an intrinsically disordered N-terminus that is key to its regulation.

Due to their stability, reduction of amides typically requires harsh conditions or strong reductants. Here the authors report a method for amide reduction with molecular hydrogen under mild conditions by use of magnetocatalysis.

Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective autophagy machinery.

A long-lived photoinduced metastable state in a quasi-one-dimensional cuprate, Sr₁₄Cu₂₄O₄₁, is reported.

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

The neuronal coding principles that underlie inter-individual perceptual similarities remains unclear. Here, the authors compared the stability of relational similarity versus activation patterns across brains and found that relational similarity was preferentially consistent across individuals, potentially underlying shared inter-subject perception.

SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live-cell super-resolution imaging.

Phonons are quanta of the vibrations of the lattice in solids. They can carry angular momentum and allow an emergent chirality. This Perspective defines various types of chiral phonon and classifies the previously observed manifestations of them.

Ultrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser.

Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

Immune cells are believed not to generate large traction forces during migration. Now, measurements of natural killer cells in dense tissue reveal bursts of large traction forces as they move through narrow pores.

Bottom-up, seeded epitaxial assembly using twisted DNA origami seeds directs the formation of 2D DNA lattices to create moiré superlattices, enabling a design space for programmable materials that combine molecular precision with mesoscale complexity.

Acquiring biomarkers from blood or sweat is limited by invasiveness or biofouling. Skin gas emissions bypass these issues, offering rich biosignals. Authors present passive sensing strategies capturing water vapor (Sweat rate), CO2, and VOCs, enabling real-time tracking of physiological changes.

The authors find, through experimental data and computational modeling, that altruistic acts stem from a motive cocktail of up to seven social and economic motives, whose strengths explain distinct behavior patterns across individuals and situations.

Hybrid optical-electrical excitation drives magnetic tunnel junctions into a regime with giant thermovoltage output exhibiting a cubic dependence on current. This nonlinear response enables accurate neuromorphic computing, achieving 93.7% digit recognition and offering a pathway toward spintronic AI systems.

An optical method for the temporal and spatial reconstruction of the electric field of few-cycle pulses is developed. The method is based on two attosecond technologies: extreme-ultraviolet interferometry and a directional electric field detector.

Charge-to-spin conversion, where a charge current generates a spin-current, is critical for spintronic devices. Usually efficient charge-to-spin conversion relies on heavy metals with large spin-orbit interactions, but here, Chakraborty et al show that high efficiency charge-to-spin conversion can be achieved without spin-orbit coupling using recently identified p-wave magnets.

Interact-omics, a high-throughput cytometry-based framework, resolves the cellular interaction landscape.

Hypothalamus participates in systemic metabolic processes, while high calorie intake increases immune activation in the central nervous system. Here the authors show that reduced regulatory T cells in the hypothalamus contribute to elevated immune activation in a high calorie environment, thereby prompting a potential therapy target for metabolic diseases.

Anodic pulsing during electrocatalytic CO₂ reduction has been shown to enhance activity and selectivity towards hydrocarbons and alcohols on copper yet the nature of the active sites remains unclear. Here, correlated spectro-microscopy in a quasi in situ experimental set-up provides information on the formation of specific facets and oxidation states under reactive conditions.

By reflecting light from a relativistically moving mirror, its frequency can be changed, which could create X-rays from visible light. Kiefer et al. make such a mirror from relativistic electrons formed by an intense laser striking a nanofoil, and shift a laser pulse from the infrared to the extreme ultraviolet.

Biological nitrogen fixation may impose stronger constraints on the carbon sink in natural terrestrial biomes and represent a larger source of agricultural nitrogen than is generally considered in analyses of the global nitrogen cycle.

Applying a magnetic field to the topological material Bi₈₈Sb₁₂ enhances the Seebeck coefficient, resulting in a high thermoelectric figure of merit zT of 1.7 at 180 K and 0.7 T.

While shaping of the electromagnetic fields around nanostructures is widely studied, the influence of the field inside the nanostructures is often overlooked. Here, Wolf et al. control the spatial distribution of third-harmonic emission in a plasmonic nanostructure, imaged by a far field Fourier method.

Molecules in intense laser fields have enhanced multiple ionization rates, caused by the ionic core and laser fields acting on the part of the molecule in the up-field. Here, direct proof of this model is presented by studying the instantaneous effect of the field direction during double ionization in ArXe.

Understanding the transport of ions, electrons and heat in magnetized plasmas is important to the development of fusion power as well as our understanding of the behaviour of astrophysical objects. Ida et al.find that stochastization of magnetic field lines in a plasma damps plasma flow more strongly than expected.