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Showing 1–6 of 6 results
Advanced filters: Author: Meixin Deng Clear advanced filters

  • The mediobasal hypothalamus plays a central role in integrating nutritional and sex-related signals to regulate energy homeostasis. Here, through snRNA-seq of the mediobasal hypothalamus in female and male mice across nutritional states, authors show that Agrp neurons are nutrition-sensitive, DA neurons exhibit transcriptional differences in a sex-dependent manner, and KNDy neurons are responsive to both sex and nutrition.

    • Jonathan C. Bean
    • Jinjing Jian
    • Yong Xu
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • Electron-deficient nitrogen-containing aromatic heterocycles can be converted into all-carbon aromatic frameworks via skeletal editing but reported methods are mainly limited to nucleophilic modification of ring-opening species. Here the authors report an electrophilic modification method which converts pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.

    • Meixin Yan
    • Yonglin Shi
    • Haiyan Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8

  • While one-to-one scaffold hopping strategies are thriving and evolving, one-to-multiple strategies remain challenging to design. Here, the authors report a scaffold hopping strategy for the skeletal editing of pyrimidines into a wide range of heteroarenes through the addition of nucleophiles, ring-opening, fragmentation, and ring-closing processes.

    • Shun Li
    • Yonglin Shi
    • Haiyan Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Regioselective C–H functionalization of pyridines remains a persistent challenge due to their inherent electronically deficient properties. Here, the authors present a strategy for the selective pyridine C3-H thiolation, selenylation, and fluorination under mild conditions via classic N-2,4-dinitrophenyl Zincke imine intermediates.

    • Shun Li
    • Juan Tang
    • Haiyan Fu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9