Search

A CMOS-compatible watt-class power amplifier based on large-mode waveguide technology is realized with an on-chip output power reaching ~1 W within a footprint of ~4 mm², enabling integrated photonics to tackle true systems level integration.

Eusocial caste systems have evolved independently multiple times. Here, Warner et al. investigate the amount of shared vs. lineage-specific genes involved in the evolution of caste in pharaoh ants and honey bees by comparing transcriptomes across tissues, developmental stages, and castes.

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.

Here, the authors demonstrate acousto-optic modulation of silicon nitride microring resonators using high-overtone bulk acoustic wave resonances, allowing modulation in the GHz range via acoustic waves. As an application, an optical isolator is demonstrated with 17 dB non-reciprocity.

Compared with intramuscular vaccine, intranasal vaccination has easier administration and local responses, but efficient antigen delivery presents an obstacle. Here the authors test an intranasal subunit vaccine fused to albumin to facilitate FcRn-mediated trans-mucosal antigen transport and demonstrate protective immunity in mouse models.

Using a gas-filled anti-resonant-reflection photonic-crystal fibre, a high-brightness table-top source of coherent carrier-envelope-phase-stable waveforms is demonstrated across seven octaves (340 nm to 40,000 nm) with ultraviolet peak powers up to 2.5 MW and terahertz peak powers of 1.8 MW, without the need for changing nonlinear crystals.

A global model finds that the environmental impacts of the food system could increase by 60–90% by 2050, and that dietary changes, improvements in technologies and management, and reductions in food loss and waste will all be needed to mitigate these impacts.

The authors showcase an optical-to-microwave conversion method using an optomechanical waveguide integrated with a piezoelectric transducer. The presented system allows bidirectional optical-to-microwave conversion with a quantum efficiency of up to—54.16 dB.

Explosive growth is attributed to the BCR::ABL1 gene 3–14 years before diagnosis of chronic myeloid leukaemia, highlighting the oncogenic potency of gene fusion and the slow and sequential trajectories of most other cancers.

Dense three-dimensional integration of photonics and electronics results in a high-speed (800 Gb s⁻¹) data interface for semiconductor chips that features 80 communication channels and consumes only tens of femtojoules per transmitted bit.

Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from six DNA methylomic studies of Alzheimer’s disease (N = 1453 unique individuals) to identify differentially methylated loci across cortex.

Extracellular vesicles have been implicated in the transmission of pathogens from the arthropod to the human host. Here the authors show that tick-derived extracellular vesicles play a role in feeding and modulate the outcome of bacterial infection.

An organic bipolar junction transistor composed of highly crystalline rubrene thin films has a device architecture that could be used in organic electronics with greatly improved high-frequency performance

This protocol describes the detailed procedures for design, assembly, and characterization of different types of double-stranded DNA nanostructures, as well as a number of downstream applications.

Andre Franke and colleagues report a genome-wide association study for psoriasis vulgaris in a German cohort with replication in German and North American psoriasis cohorts. They identify variants in TRAF3IP2, encoding a protein involved in IL-17 mediated T-cell immune response, associated with psoriasis.

An important feature of biochemical labeling strategies is their inherent biocompatibility. This protocol enables systematic evaluation of the reaction biocompatibility of (new) synthetic methodologies via bio-additive-based screening.

Different motor symptoms respond variably to deep brain stimulation in Parkinson’s Disease. Rajamani et al. suggest that this variability may be due to tremor, bradykinesia, rigidity, and axial symptoms being associated with a gradient of brain circuits.

Here, the authors identify a broadly neutralizing antibody from an HIV-infected person that recognizes the membrane-proximal external region (MPER) of HIV envelope glycoprotein (Env) and has a short CDRH3 and low polyreactivity. Structural analysis shows how the antibody binds the MPER and Env on the viral membrane.

Most electrostatic actuators suffer from an operational instability, the so-called pull-in effect. Here, the authors report an electrostatic actuator concept which makes the huge electrostatic forces within nanometre small electrode separation accessible for large deflections.

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Intrinsic limitations of nanoporous graphene limit its applications in water treatment. Here the authors produce post-treatment-free, low-cost graphene-based membranes from renewable biomass and demonstrate their high water permeance and antifouling properties using real seawater.

Standard homodyne detection is intrinsically limited by the electronic bandwidth of the photo-detectors. Here, the authors exploit parametric amplification to demonstrate sub-shot-noise optical quadrature measurement across a bandwidth of 55 THz.

A solid-state laser that generates 10 × 10 vortex laser arrays is demonstrated. The topologies are actively tunable.

A vibrational spectroscopy technique that measures the electric field emitted from organic molecules following infrared illumination allows their molecular fingerprints to be separated from the excitation background, even in complex biological samples.

Atomic clocks and their networks are useful tools for optical communications and frequency metrology. Here the authors use phase stabilization and active tip-tilt to suppress atmospheric effects and enable optical frequency transfer through free-space.

Solvent-free, supersoft and superelastic polymer melts and networks made from bottlebrush macromolecules can display low modulus, high strain at break, and extraordinary elasticity.

Multidimensional photonic computing is a framework that combines classical and quantum approaches, leveraging the properties of light. This Perspective explores its potential to enable scalable, neuromorphic photonic quantum systems suited to data-intensive and complex computational tasks.

Somatic mutations obtained from laser microdissected biopsies of human tissues are used to reconstruct the developmental phylogenies of these tissues back to the zygote.

Brillouin scattering microscopy is prone to artefacts and inconsistencies. This Consensus statement provides recommendations for measuring and reporting relevant parameters with the aim of standardizing protocols and improving the comparability of studies.

The adipokine leptin modulates intestinal inflammation in mice. Here the authors describe a patient with inflammatory bowel disease and lipodystrophy, providing evidence that leptin aggravates intestinal inflammation with proinflammatory effects on leukocytes that are reversible by TNFα blockade.

An environmentally safe means of mosquito control is the application of Bacillus thuringiensis israelensis, which produces a cocktail of four naturally crystalline proteins exclusively toxic to mosquito. Here the authors report the atomic-resolution structures of Bti Cry11Aa and related Btj Cry11Ba solved de novo through Serial Femtosecond Crystallography on naturally-occurring nanocrystals.

In an application of terahertz phonon engineering, terahertz phonons were generated, detected and manipulated through precise integration of atomically thin layers in van der Waals heterostructures.

Optical modulators on silicon promise to deliver ultralow power communication networks between or within computer chips. Here, the authors demonstrate a silicon modulator operating with less than one femtojoule energy and are able to compensate for thermal drift over a 7.5 °C temperature range.