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This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

An autonomous robotic platform enables high-throughput, low-cost, and high-volume phenotypic measurements in maize canopies, facilitating the understanding of genotype, environment, and management interactions (GxExM) with high accuracy.

A diet–microorganism pathway involving conjugated linoleic acid, interleukin-18, intraepithelial lymphocytes and the transcription factor hepatocyte nuclear factor  4γ modulates the host mucosal immune system.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

This study estimates the green cooling distribution and the population most exposed to heat in 14 major European areas. It found that lower-income residents, immigrants and unemployed residents are more vulnerable compared with upper-income residents, nationals and homeowners.

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

The benefits and risks of nature to human health have been studied, however, robust empirical research on forest biodiversity and health outcomes is still lacking. Here the authors use a unique dataset from 164 European forest stands to explore the associations between forest types and well-being.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Climate warming increases evapotranspiration (ET) more in boreal peatlands than in forests. Observations show that peatland ET can exceed forest ET by up to 30%, indicating a stronger warming response in peatlands. Earth system models do not fully account for peatlands and hence may underestimate future boreal ET.

Using an idealized multi-model experiment and a new hysteresis quantification method, this study shows that equivalent carbon dioxide removal fails to symmetrically reverse CO₂-emissions-induced agroecological droughts, revealing irreversible impacts in hotspots in the Mediterranean, northern Central America, southern Africa and southern Australia, necessitating urgent adaptation planning.

Three complementary decomposition experiments across a climatic gradient in Europe, representing 110 different tree species mixtures in 194 forest plots, reveals that macroclimate is a dominant control on plant litter decomposition through both direct and indirect effects.

Increasing the accuracy of crop productivity estimates is key to ensuring global food security. This Article develops temperature response functions that reduce error in grain yield by 19% to 50%.

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

Fire is an important component of many African ecosystems, but prediction of fire activity is challenging. Here, the authors use a statistical framework to assess the seasonal environmental drivers of African fire, which allow for a better prediction of fire activity.

Selective chemical upcycling of polyolefin mixtures remains challenging due to the structural similarity of their backbones. Now it has been shown that a single-site nickel catalyst can preferentially and efficiently cleave branched C–C bonds, enabling the hydrogenolytic separation of isotactic polypropylene from mixtures containing both isotactic polypropylene and polyethylene.

Three key axes of variation of ecosystem functional changes and their underlying causes are identified from a dataset of surface gas exchange measurements across major terrestrial biomes and climate zones.

Ground truthed thermal data from a new NASA satellite combined with experimental warming data from three continents in an empirical model suggests that tropical forests are closer to a high temperature threshold than previously thought.

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.

Evapotranspiration (ET) is a key process connecting the land to the atmosphere. This Review details the characteristics and drivers of ET changes since the 1980s, noting a positive and accelerating ET trend arising from global greening.

Nanoplasmonic structures that can detect trace analytes via surface-enhanced Raman spectroscopy typically require sophisticated nanofabrication techniques. Self-assembly of gold nanoparticles into close-packed arrays at liquid/liquid and liquid/air interfaces is now used for the detection of multi-analytes from aqueous, organic or air phases.

Post-traumatic stress disorder (PTSD) is a common mental health problem. Here, the authors report a GWAS from the Psychiatric Genomics Consortium in which they identify two risk loci in European ancestry and one locus in African ancestry individuals and find that PTSD is genetically correlated with several other psychiatric traits.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Remotely sensed NDVI data and contemporary field data from 84 grasslands on 6 continents show increasing divergence in aboveground plant biomass between sites in different bioclimatic regions.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

A Stereo-seq and scRNA-seq atlas of mouse liver in homeostasis and regeneration after partial hepatectomy identifies zonated genes, pathways, cell–cell interactions and gene regulatory networks. Functional validation finds that cooperation between TBL1XR1 and β-catenin activates hepatocyte proliferation.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

Genomic studies often lack representation from diverse populations, limiting equitable insights. Here, the authors show that the BIG Initiative captures extensive genetic diversity and reveals ancestry-linked health disparities in a community-based Mid-South cohort.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Lidar and optical satellite observations of Amazon forests indicate consistent canopy structure and reflectance during the dry season, challenging the paradigm of light-limited tropical forest productivity.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native sites, thereby advancing therapeutic antibody development in this host.

Functional variations in tropical forests can be determined from remotely sensed forest trait and structural attributes at spatial resolutions relevant to satellite-based observations, according to a coarse resolution analysis of airborne remotely sensed data in Malaysian Borneo.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Widespread but contrasting delayed responses of ecosystem productivity to spring warmth across northern ecosystems is inferred from satellite data, with higher areal fractions of adverse effects than beneficial effects.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.