A new study shows that coordinated regulation of transcription due to a transcriptional ripple effect is widespread in the mammalian genome. Nishida and colleagues have found that induction of immediate early genes is accompanied by upregulation of genes in the vicinity; this process is dependent on the MAPK pathway and the transcription factor SRF.
- Miki Ebisuya
- Takuya Yamamoto
- Eisuke Nishida
