The identification of mutations in ion channels has been crucial to understanding the pathogenesis of cardiac arrhythmias, but the aetiology of a considerable number of arrhythmogenic disorders remains unknown. In this Review, Lazzerini and colleagues discuss the role of autoimmunity in the pathogenesis of cardiac arrhythmias, describing how different autoantibodies against ion channels in the heart participate in the development of these conditions.
- Pietro Enea Lazzerini
- Pier Leopoldo Capecchi
- Mohamed Boutjdir