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Conditional knockout of LARP4 in naive CD4⁺ T cells leads to attenuated quiescence exit and clonal expansion.

Electrochemical CO_x reduction to multi-carbon products is hindered by low energy efficiency, in part due to sluggish ion transport across charge-selective membranes used in electrolysers. Here the authors use a porous, non-charge-selective separator that enhances ion transport and improves performance for CO electrolysis.

The authors show that the endoplasmic reticulum-phagy receptor FAM134B interacts with SCAP to regulate cholesterol biosynthesis, sequestering SCAP when endoplasmic reticulum cholesterol is high but dissociating upon low cholesterol levels, allowing SCAP to activate cholesterol synthesis.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Existing solutions based Advanced Encryption Standard to address the security issues of nonvolatile memories incurs significant performance and power overhead. Here, the authors propose a lightweight XOR-gate based encryption/decryption technique by exploiting in-situ array operations, which achieves significant area/latency/power reduction compared to conventional designs.

Secondary arylalkylamines represent important building blocks for organic synthesis, and as such their straightforward synthesis from readily available chemicals remains a priority in organic chemistry. Here, the authors report a synthesis of arylalkylamines from nitroarenes and carbazates via paired electrolysis.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synthesis, and delayed radial glial cell specification.

The authors show that LARP4 drives T cell dysfunction in tumors by promoting hypertranslation of oxidative phosphorylation-related mRNAs, resulting in mitochondrial dysfunction. They also target LARP4 to enhance T cell persistence and anti-tumor activity and provide a CAR T cell strategy for treating solid and liquid tumors.

A versatile nano-adaptor is used to construct multi-specific nano-antibodies for treatment of tumours in mice.

Understanding base excision repair leads to the development of more efficient mitochondrial adenine editors.

Hepatitis delta virus (HDV) depends on the envelope proteins of hepatitis B virus (HBV) for virion production. Here, Lempp et al. produce a cell line expressing HBV envelope proteins and their receptor, which allows continuous secretion of infectious progeny HDV and testing of antiviral drugs.

Cellular and molecular heterogeneity contributes to the insufficient immunogenicity of glioblastoma (GBM), ultimately leading to limited immune cell infiltration. Here this group reports a GBM therapeutic strategy by activating endogenous cGAS-STING signaling pathway by modulating mitochondrial electron transport chain thereby augmenting the immune responsiveness of GBM.

Water in the mantle transition zone beneath Northeast Asia is sourced from the Earth’s surface and introduced by the subducted Pacific slab, according to a study of potassium isotopes from Cenozoic volcanics.

PARP inhibitors are effective in cancer patients with BRCA1 mutations but whether this can extend to BRCA1 wildtype patients by targeting BRCA1 transcriptional regulation is unclear. Here, in preclinical models of pancreatic cancer, the authors identify OFD1 as a transcriptional regulator of BRCA1 via the DREAM complex and as a potential therapeutic target in combination with PARP inhibition.

Traditional solution- and vacuum-deposition may leave pinholes on film surface or suffer from low throughput, respectively. Here, authors vacuum-deposit a 2D capping perovskite layer on solution deposited 3D bulk film, realizing pinhole-free solar submodules with certified efficiency close to 22%.

This work achieves a flexible organic ferroelectric crystal with interesting plasticity by implementing fluorination on anion, making it a competitive candidate for flexible and wearable devices.

Sulfonyl fluorides have potential application in chemical biology, materials science, and drug discovery, but their preparation remains challenging. Here, the authors report an air-stable fluorosulfonylating reagent that enables the radical fluorosulfonylation, hydrofluorosulfonylation and migratory SO₂F-difunctionalization of unsaturated hydrocarbons to construct a variety of sulfonyl fluoride compounds.

Electrochemical transformations use electrons and electron holes instead of chemical oxidants and reductants as reagents. Here, the authors report an electrochemical reductive deaminative cross-coupling of Katrizky salts with various radical acceptors, including examples of fluoroalkenylation, alkynylation and thiolation.

Non-intrusive integration of metasurfaces with vertical cavity surface-emitting lasers enables fully arbitrary wavefront control for directional laser emission.

Innate and adaptive immunity are equally important for the anti-tumor response and immunotherapy simultaneously activating both arms could have therapeutic benefits. Here authors show that a composite nanoparticle platform that immobilizes monoclonal antibodies targeting PD-L1, 4- 1BB and NKG2A or TIGIT recruits and activates both NK and CD8 + T cells.

Metastasis-associated recurrence is a major cause of poor prognosis in hepatocellular carcinoma. Here, the authors show that expression of choroideremia-like (CHML) is elevated and associates with poor prognosis in hepatocellular carcinoma, and mechanistically CHML promotes metastasis in a Rab14-dependent manner.

There is great interest in molybdenum disulphide for electronic devices but the mechanism of charge transport remains elusive. Qiu et al. find that sulphur vacancies introduce localized donor states within the bandgap, enabling low-carrier-density transport via hopping.

This work presents a hybrid fluorescence and magnetic resonance imaging (HyFMRI) platform for concurrent measurements of neuronal, astrocytic, and brain-wide hemodynamic responses in mice.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Observing spin-changing atom–molecule collisions with quantum-state precision provides clues of short-range interactions. Now it is shown that the outcomes of the KRb + Rb collision only align with a statistical model after assuming the non-conservation of mechanical angular momentum. The observations also contradict coupled-channel calculations that neglect vibrations and conical intersections.

Electrosynthesis of n-propanol from CO has been limited by poor selectivity and low product concentration. Here a Sn–Cu catalyst/carbon/ionomer heterojunction is prepared where the adjacent atomic active sites favour the coupling of C₁ and C₂ intermediates to C₃ product with 47% Faradaic efficiency and the reversal of electro-osmotic drag concentrates the product to 30 wt%.

Selective conversion of CO₂ and H₂ into aromatics remains challenging due to the high unsaturation degree and complex structure of aromatics. Here the authors report a composite catalyst of ZnAlOx and H-ZSM-5 which promotes the formation of aromatics with high selectivity while inhibiting CO and CH₄ formation in CO₂ hydrogenation reactions.

Inflammasomes are multiprotein complexes, including the protein ASC, that assemble in response to inflammatory stimulation. Here the authors characterise the regulation of ASC during inflammasome formation and show the involvement of SUMOylation and zinc-finger and BTB domain-containing protein 16 (ZBTB16).

The geographical distribution of dengue in China has been expanding this century. Here, the authors report the spatiotemporal distribution of dengue in China using surveillance data from 2013–2020 and combine it with mosquito abundance and human mobility data to simulate transmission at the city scale.

Stem cell therapies have huge potential but face challenges. Here, the authors report on a serum-tolerant boronated polyethyleneimine assembly with apolipoprotein corona, to carry miRNA-124 and all-trans retinoic acid derivative to achieve efficient stem-cell transfection and neural differentiation.

Solution-processed small-molecule solar cells with almost 100% internal quantum efficiency and a power conversion efficiency of 9% are reported. The cells make use of a donor molecule called DRCN7T and use PC71BM as an acceptor.

International trade links regions of production and consumption. Analyses with a multiregional input–output model based on trade data reveal that much of East Asia’s aerosol radiative forcing is tied to consumption in developed countries.

The authors reveal a complex polarization network in twisted bilayer h-BN, featuring edge polarization topology and sliding ferroelectricity, driven by the interplay of ferroelectric and piezoelectric effects.

Suppressing wheat ASPARTIC PROTEASE 1 promotes the homeostasis of PsbO, stabilizes the photosystem complex and elongates the duration of active photosynthesis, leading to increases in the CO₂ assimilation rate, kernel weight and yield.

Fan and colleagues show that FLASH radiation promotes proinflammatory polarization of tumor-associated macrophages, which in turn increases T cell influx in medulloblastoma and synergizes with CAR-T cell therapy.