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Showing 1–50 of 209 results
Advanced filters: Author: Nicholas O. Fischer Clear advanced filters
  • Li-Fraumeni syndrome is a cancer predisposition disorder caused by TP53 variants, but the way different TP53 variants contribute remains unclear. Here, the authors analyse TP53 mutagenesis datasets and identify five TP53 variant clusters that show associations with specific cancer patterns as well as potential clinical strategies.

    • Nicholas W. Fischer
    • Noel Ong
    • David Malkin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • A synthetic biology system called SMART has been developed that uses conditional protein splicing for the programmable ligation of functional proteins from previously defined molecular combinations on cell surfaces.

    • Christian Kofoed
    • Girum Erkalo
    • Tom W. Muir
    ResearchOpen Access
    Nature
    Volume: 645, P: 793-800
  • Down syndrome causes extensive Alzheimer’s disease pathology in all individuals and has been instrumental in development of the amyloid hypothesis in AD. Here, the authors use proteomics on Down syndrome spinal fluid and brain tissues to illustrate the common and unique changes in DSAD compared to other genetic forms of AD and the more common late-onset form of the disease.

    • Laia Montoliu-Gaya
    • Shijia Bian
    • Erik C. B. Johnson
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.

    • Zachary Sethna
    • Pablo Guasp
    • Vinod P. Balachandran
    ResearchOpen Access
    Nature
    Volume: 639, P: 1042-1051
  • FHL1A is a crucial host factor for alphavirus infection but its impact on pathogenesis is unclear. Here, the authors use a FHL1−/− knockout mouse model to show that the FHL1 splice variant impacts arthritis and myositis after chikungunya or o’nyong-nyong infections but not Ross River or mayaro virus infection.

    • Wern Hann Ng
    • Xiang Liu
    • Suresh Mahalingam
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Polymers are known to spontaneously produce micro- and nanoplastics but the mechanisms by which environmentally-triggered Å-level random bond breaking events lead to the formation of these relatively large fragments are unclear. Here, the authors show that chain scission accumulates in the amorphous phase of a semicrystalline morphology which leads to mechanical failure and the concurrent release of nanoplastics even under quiescent conditions.

    • Nicholas F. Mendez
    • Vivek Sharma
    • Sanat K. Kumar
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • The authors demonstrate broadband terahertz emission from a two-dimensional van der Waals ferroelectric semiconductor, NbOI2, that originates from its efficient optical rectification and apply it to realize in situ near-field terahertz spectroscopy.

    • Taketo Handa
    • Chun-Ying Huang
    • Xiaoyang Zhu
    Research
    Nature Materials
    Volume: 24, P: 1203-1208
  • Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

    • Jared Carlson-Stevermer
    • Reed Kelso
    • Travis Maures
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7
  • Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • Yukinori Okada
    • James F Wilson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17
  • Small cell lung cancer presents high and multi-site metastatic potential. Here, the authors discover that FOXA2, regulated by ASCL1, promotes multi-site metastasis in small cell lung cancer by inducing a fetal neuroendocrine gene expression program.

    • Kenta Kawasaki
    • Sohrab Salehi
    • Charles M. Rudin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The primary structures of four bovine clathrin light chains have been determined. Light chains LCa and LCb are homologous proteins encoded by different genes. In the brain the messenger RNA from these genes undergoes differential splicing to yield proteins having centrally inserted brain-specific sequences. A potentially α-helical region of the clathrin light chains shows homology with intermediate filament proteins.

    • Antony P. Jackson
    • Heng-Fong Seow
    • Peter Parham
    Research
    Nature
    Volume: 326, P: 154-159
  • Alkoxycarbonylation reactions are widely used in the chemical industry, but their sustainability is often hindered by inefficient CO utilization. Here, the authors tackle the challenge by developing a sustainable and efficient carbonylation process for producing methyl propionate, achieving high CO utilization and regioselectivity.

    • Bin Zhang
    • Haiyang Yuan
    • Graham J. Hutchings
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

    • Ken Suzuki
    • Konstantinos Hatzikotoulas
    • Eleftheria Zeggini
    ResearchOpen Access
    Nature
    Volume: 627, P: 347-357
  • A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

    • Roy Burstein
    • Nathaniel J. Henry
    • Simon I. Hay
    ResearchOpen Access
    Nature
    Volume: 574, P: 353-358
  • A survey of the cellular RNA-binding proteins (RBPs) that interact with dengue virus and Zika virus genomic RNA identifies ribosome-binding protein 1 and vigilin as bona fide RBPs able to promote viral RNA translation, replication and stability.

    • Yaw Shin Ooi
    • Karim Majzoub
    • Jan E. Carette
    Research
    Nature Microbiology
    Volume: 4, P: 2369-2382
  • Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

    • Iris Hordijk
    • Lourens Poorter
    • Thomas W. Crowther
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Characterization of clinical isolates of the cryptic fungal pathogen Aspergillus latus revealed traits that distinguish it from other species. Steenwyck et al show that A. latus originated via allodiploid hybridization with both parental subgenomes actively expressed.

    • Jacob L. Steenwyk
    • Sonja Knowles
    • Antonis Rokas
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Solvent structuring affects the energy landscape of catalytic reactions, but the quantitative understanding of such effects remains difficult. Now, the structure of water within the micropores of different zeolites is disclosed together with the effects that its reorganization has over alkene epoxidation catalysis.

    • Daniel T. Bregante
    • Matthew C. Chan
    • David W. Flaherty
    Research
    Nature Catalysis
    Volume: 4, P: 797-808
  • Sea salt data from an ice core record show that Antarctica’s Ronne Ice Shelf survived the last interglacial, the last period of enhanced and sustained global warmth about 125,000 years ago.

    • Eric W. Wolff
    • Robert Mulvaney
    • Nicholas R. Golledge
    ResearchOpen Access
    Nature
    Volume: 638, P: 133-137
  • The ever-growing need for highly functional, compact, and integrated microfluidic devices often incurs lengthy and expensive manufacturing processes. Here, authors introduce a generalized 3D printing process that enables fast parallel fabrication of miniaturized, high resolution 3D components.

    • Jose L. Sanchez Noriega
    • Nicholas A. Chartrand
    • Gregory P. Nordin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • Bio-based polyethylene-like materials with tunable thermal and mechanical properties have been synthesized from plant-derived diols using an acceptorless dehydrogenative polymerization strategy. Now it has been shown that this atom-economical and mass-economical approach employing non-precious metal catalysts enables closed-loop recycling and advances sustainable solutions for the circular plastic economy.

    • Xin Liu
    • Zhitao Hu
    • Garret M. Miyake
    Research
    Nature Chemistry
    Volume: 17, P: 500-506
  • Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integrated stress response.

    • Gustavo Della-Flora Nunes
    • Emma R. Wilson
    • M. Laura Feltri
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • Previous studies have reported MLL-AF4 binding at intragenic and intergenic enhancers, however, the role of MLL-AF4 in enhancer function remains to be investigated. Here, the authors show that MLL-AF4 cooperates with PAF1 and FACT at enhancers to promote high-density interactions with oncogene promoters in leukemia.

    • Nicholas T. Crump
    • Alastair L. Smith
    • Thomas A. Milne
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20
  • Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

    • Anne E. Justice
    • Thomas W. Winkler
    • L Adrienne Cupples
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19
  • A multi-ancestry genome-wide association study for age at menarche followed by fine mapping and downstream analysis implicates 665 pubertal timing genes, such as the G-protein-coupled receptor 83 (GPR83) and other genes expressed in the ovaries involved in the DNA damage response.

    • Katherine A. Kentistou
    • Lena R. Kaisinger
    • Ken K. Ong
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1397-1411
  • Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

    • Marcel den Hoed
    • Mark Eijgelsheim
    • Ruth J F Loos
    Research
    Nature Genetics
    Volume: 45, P: 621-631
  • Lanthanide-doped upconverting nanoparticles exhibiting a 33,000 times increase in brightness and a 100 times increase in efficiency over bare upconverting nanoparticles are demonstrated. The findings are relevant in fields from solar energy to biophotonics.

    • David J. Garfield
    • Nicholas J. Borys
    • P. James Schuck
    Research
    Nature Photonics
    Volume: 12, P: 402-407
  • Timothy Frayling, Joel Hirschhorn, Peter Visscher and colleagues report a meta-analysis of genome-wide association studies for adult height in 253,288 individuals. They identify 697 variants in 423 loci significantly associated with adult height and find that these variants cluster in pathways involved in growth and together explain one-fifth of the heritability for this trait.

    • Andrew R Wood
    • Tonu Esko
    • Timothy M Frayling
    Research
    Nature Genetics
    Volume: 46, P: 1173-1186
  • Ader et al. find a grommet-like role for ESCRTs distinct from their nuclear envelope sealing function after spindle pole body extrusion. The grommet works with spindle pole body components that establish a diffusion barrier to maintain compartmentalization.

    • Nicholas R. Ader
    • Linda Chen
    • C. Patrick Lusk
    Research
    Nature Cell Biology
    Volume: 25, P: 1465-1477
  • Genomic profiling of tumours can help tailer treatments to the patient, however, it often fails to accurately predict therapeutic outcomes. Here, the authors combine molecular and functional characterisation via BH3 profiling to identify therapeutically targetable vulnerabilities in glioma.

    • Elizabeth G. Fernandez
    • Wilson X. Mai
    • David A. Nathanson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • The aggregation of the neuronal protein α-Synuclein is associated with the onset of Parkinson’s disease. Here the authors report a two-dimensional Fragment Assisted Structure-based technique to find antagonists of α-Synuclein aggregation and show its promise for identifying lead therapeutics for Parkinson’s disease.

    • Nicholas H. Stillman
    • Johnson A. Joseph
    • Sunil Kumar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25
  • Two degraders targeting zinc finger transcription factor IKZF2 (Helios) were developed by reprogramming CRL4CRBN E3 ligase, and the pharmacologic degradation of Helios results in Treg destabilization.

    • Eric S. Wang
    • Alyssa L. Verano
    • Eric S. Fischer
    Research
    Nature Chemical Biology
    Volume: 17, P: 711-717
  • Trees come in all shapes and size, but what drives this incredible variation in tree form remains poorly understood. Using a global dataset, the authors show that a combination of climate, competition, disturbance and evolutionary history shape the crown architecture of the world’s trees and thereby constrain the 3D structure of woody ecosystems.

    • Tommaso Jucker
    • Fabian Jörg Fischer
    • Niklaus E. Zimmermann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Phosphorene nanoribbons demonstrate extraordinary magnetic properties, ranging from large internal fields in films to macroscopic alignment in solution, which can be coupled to photoexcitations that localize to the magnetic edge of these ribbons.

    • Arjun Ashoka
    • Adam J. Clancy
    • Raj Pandya
    ResearchOpen Access
    Nature
    Volume: 639, P: 348-353
  • Photosynthetic formation of manganese (Mn) oxides from dissolved Mn ions was proposed to occur in ancestral photosystems before oxygenic photosynthesis evolved. Here, the authors provide evidence for this hypothesis by showing that photosystem II devoid of the Mn cluster oxidises Mn ions leading to formation of Mn-oxide nanoparticles.

    • Petko Chernev
    • Sophie Fischer
    • Holger Dau
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10