Asymmetric Notch signalling is important in many developmental contexts, including the division of fly sensory organ precursor (SOP) cells. Here, Notch is inactivated by Numb in the resulting pIIb daughter cell while remaining active in pIIa to direct cell fate. Using live imaging, Schweisguth and colleagues reveal that Numb and Sanpodo act together, modulating Notch trafficking to deplete it on the pIIb side of the SOP cytokinetic furrow.
- Lydie Couturier
- Nicolas Vodovar
- François Schweisguth
