Nature Search

Multivariate protein landscape of host response in hospitalised patients with suspected infection in the emergency department

Authors measure plasma proteins in a cohort of hospitalised patients presenting to the emergency department with suspected infection, revealing six discrete host response clusters that were driven by pathogen exposure and organ dysfunction, and had distinct clinical characteristics, hospital courses, and responses to treatment.

Pratik Sinha
Alexandra B. Spicer
Matthew M. Churpek
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

Stuart H. Orkin
Haig H. Kazazian Jr
Patricia J. V. Giardina
Research15 Apr 1982
Nature

Volume: 296, P: 627-631
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development

The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates the CSF protein composition and instructs cortical development.

Ya’el Courtney
Joshua P. Head
Maria K. Lehtinen
ResearchOpen Access28 May 2025
Nature Neuroscience

Volume: 28, P: 1446-1459
Large protein databases reveal structural complementarity and functional locality

Researchers mapped the protein structure landscape, revealing structural complementarity across databases and functional clustering in specific regions. Their web tool helps explore this space, unlocking new insights into protein roles, evolution, and diversity.

Paweł Szczerbiak
Lukasz M. Szydlowski
Tomasz Kosciolek
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Active night-time tweeting is associated with meaningfully lower mental wellbeing in a UK birth cohort study

Daniel Joinson
Claire M. A. Haworth
Oliver S. P. Davis
ResearchOpen Access09 Oct 2025
Scientific Reports

Volume: 15, P: 1-13
Simulation of enzyme–substrate encounter with gated active sites

Rebecca C. Wade
Brock A. Luty
J. Andrew McCammon
Research01 Jan 1994
Nature Structural Biology

Volume: 1, P: 65-69
Induction of Immunological Tolerance by Porcine Liver Allografts

R. Y. CALNE
R. A. SELLS
D. A. L. DAVIES
Research02 Aug 1969
Nature

Volume: 223, P: 472-476
Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance

Brain-machine interfaces are hindered by neuroinflammation. Here, the authors found that bacterial sequences invade the brain post-microelectrode implantation. Antibiotic-treated mice showed reduced bacterial presence and altered neuroinflammatory profile, temporarily improving recording performance.

George F. Hoeferlin
Sarah E. Grabinski
Jeffrey R. Capadona
ResearchOpen Access20 Feb 2025
Nature Communications

Volume: 16, P: 1-27
Exome analysis links kidney malformations to developmental disorders and reveals causal genes

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Hila Milo Rasouly
Sarath Babu Krishna Murthy
Ali G. Gharavi
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial

In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [¹⁷⁷Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [¹⁷⁷Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

Edmond M. Kwan
Sarah W. S. Ng
Alison Y. Zhang
Research27 May 2025
Nature Medicine

Volume: 31, P: 2722-2736
Interruption of two decades of Jakobshavn Isbrae acceleration and thinning as regional ocean cools

Jakobshavn Isbrae, the largest source of ice mass loss from the Greenland Ice Sheet, has been re-advancing since 2016 after a decades-long retreat, reveals an analysis of airborne altimetry and satellite data. The advance coincides with regional ocean cooling.

Ala Khazendar
Ian G. Fenty
Josh Willis
Research25 Mar 2019
Nature Geoscience

Volume: 12, P: 277-283
Aboveground Net Primary Productivity in Grazed and Ungrazed pastures: Grazing Optimisation Hypothesis or Local Extinction of Vegetation Species

Silvanus Otieno
Jesse Njoka
Robinson Ngugi
ResearchOpen Access23 Jul 2009
Nature Precedings

P: 1
Primordial density fluctuations and the structure of galactic haloes

P. J. Quini
J. K. Salmon
W. H. Zurek
Research24 Jul 1986
Nature

Volume: 322, P: 329-335
Rifampicin Sensitivity of the Components of DNA-dependent RNA Polymerase

E. di MAURO
L. SNYDER
G. P. TOCCHINI-VALENTINI
Research10 May 1969
Nature

Volume: 222, P: 533-537
Azaserine, A New Tumour-Inhibitory Substance: Isolation and Characterization of Azaserine

QUENTIN R. BARTZ
CAROLE C. ELDER
ALBERT RYDER
Research09 Jan 1954
Nature

Volume: 173, P: 72-73
HIF1 activity in photoreceptors drives type 3 neovascularization and retinal atrophy in a new mouse model of age-related macular degeneration

Fredy Geiger
Thomas Heigl
Christian Grimm
ResearchOpen Access06 Oct 2025
Cell Death & Disease

Volume: 16, P: 1-12
C1 inhibitor hinge region mutations produce dysfunction by different mechanisms

Alvin E. Davis III
Kulwant Aulak
Fred S. Rosen
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 354-358
Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice

Vitamin A deficiency exacerbates invasive non-typhoidal Salmonella infection in mice, revealing a restrictive role for SLC11A1 in neutrophils.

Kristen L. Lokken-Toyli
Vladimir E. Diaz-Ochoa
Renée M. Tsolis
ResearchOpen Access19 Feb 2024
Nature Microbiology

Volume: 9, P: 727-736
Systematic multi-trait AAV capsid engineering for efficient gene delivery

Conventional selections of AAV capsid libraries are inefficient at searching sequence space. Here the authors report ‘Fit4Function’, a generalizable ML approach for systematically engineering multi-trait AAV capsids, and use this to predict cross-species traits of peptide-modified AAV capsids.

Fatma-Elzahraa Eid
Albert T. Chen
Benjamin E. Deverman
ResearchOpen Access04 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Tryptamine Receptors in the Central Nervous System

J. R. VANE
H. O. J. COLLIER
P. B. BRADLEY
Research09 Sept 1961
Nature

Volume: 191, P: 1068-1069
Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials

A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

Cara A. Griffiths
Xiaochao Xue
Matthew J. Paul
ResearchOpen Access29 Apr 2025
Nature Biotechnology

P: 1-10
Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair

MUTYH removes A mis-incorporated opposite oxidized guanine to thwart mutations. Here, the authors present crystal structures and assess functional impacts and molecular dynamics of cancer-linked variants to illuminate how the [4Fe-4S] cofactor and active site are allosterically connected with significance for fidelity and clinical impact.

Carlos H. Trasviña-Arenas
Upeksha C. Dissanayake
Sheila S. David
ResearchOpen Access16 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Speciation in molluscs from Turkana Basin (reply)

P. G. WILLIAMSON
Research18 Aug 1983
Nature

Volume: 304, P: 661-663
Carbon Isotope Ratios and Palaeosalinities of Purbeck–Wealden Carbonates

P. ALLEN
M. L. KEITH
Research01 Dec 1965
Nature

Volume: 208, P: 1278-1280
Human infections with highly pathogenic avian influenza A(H5N1) viruses in the United States from March 2024 to May 2025

In an updated report on 70 laboratory-confirmed highly pathogenic avian influenza A H5N1 cases in the USA between March 2024 and May 2025, the absence of human-to-human transmission to date was confirmed, with no known mutations of resistance to neuroaminidase inhibitors.

Melissa A. Rolfes
Krista Kniss
Sonja J. Olsen
Research25 Jul 2025
Nature Medicine

P: 1-10
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.

Yashavanth Shaan Lakshmanappa
Sonny R. Elizaldi
Smita S. Iyer
ResearchOpen Access22 Jan 2021
Nature Communications

Volume: 12, P: 1-14
Localization of Acyl Carrier Protein in Escherichia coli

H. VAN DEN BOSCH
JOSEPH R. WILLIAMSON
P. ROY VAGELOS
Research24 Oct 1970
Nature

Volume: 228, P: 338-341
A substrate-multiplexed platform for profiling enzymatic potential of plant family 1 glycosyltransferases

Most enzymes involved in plant natural products biosynthesis remain uncharacterized. Here, the authors establish a screening pipeline and apply it to family 1 glycosyltransferases to reveal their promiscuity and preference for planar, hydroxylated aromatic substrates.

Sasilada Sirirungruang
Vincent Blay
Patrick M. Shih
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Effects of demand and recycling on the when and where of lithium extraction

Powering electric vehicles hinges on the availability to extract lithium from reserves. Modelling now shows the likely number of new lithium deposit openings required by 2050 if the demand for larger battery packs continues and suggests moderating battery size and improving recycling to reduce mine openings.

P. Busch
Y. Chen
A. Kendall
Research29 May 2025
Nature Sustainability

Volume: 8, P: 773-783
Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer

N-Myc fuels neuroendocrine prostate cancer. Here, the authors describe how targeting HSP70, a major N-Myc partner, coordinates with STUB1 to facilitate the degradation of N-Myc. This process slows neuroendocrine prostate cancer growth, improves the efficacy of Aurora Kinase A inhibitors, and reduces neuroendocrine pathway activity.

Pengfei Xu
Joy C. Yang
Chengfei Liu
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Extended enriched gas in a multi-galaxy merger at redshift 6.7

JWST data reveal a multi-galaxy merger 800 Myr after the Big Bang, likely a progenitor of massive quiescent galaxies seen at later times. Its extended [O iii] halo offers direct evidence of early metal enrichment via tidal stripping.

Weida Hu
Casey Papovich
Justin Cole
Research15 Aug 2025
Nature Astronomy

P: 1-11
An mRNA vaccine encoding five conserved Group A Streptococcus antigens

There are currently no licensed vaccines to prevent Group A Streptococcus (GAS) infections. In this study, the authors evaluate the immune response and preclinical efficacy of a multicomponent mRNA lipid-nanoparticle vaccine against GAS.

Nichaela Harbison-Price
Ismail Sebina
Mark J. Walker
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Biological Activities of Some α-Dithiosemicarbazones

P. A. BARRETT
ELIZABETH BEVERIDGE
J. K. H. WILDE
Research26 Jun 1965
Nature

Volume: 206, P: 1340-1341
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

Jiahuai Wang
Youwei Yan
Stephen C. Harrison
Research29 Nov 1990
Nature

Volume: 348, P: 411-418
Quasars of redshift z = 4.43 and z = 4.07 in the South Galactic Pole field

S. J. Warren
P. C. Hewett
M. J. Irwin
Research03 Dec 1987
Nature

Volume: 330, P: 453-455
Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex

What drives the development of lateralized sound processing in the brain remains unclear. Here, the authors find that sex and hemispheric identity underlie asynchronous development between the auditory cortices, leading to distinct functional representations in adulthood.

Ashlan P. Reid
Demetrios Neophytou
Hysell V. Oviedo
ResearchOpen Access17 Apr 2025
Nature Communications

Volume: 16, P: 1-12
Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like properties

Bovine H5N1 viruses are lethal in laboratory animals, but they retain avian traits including limited transmission. Their responsiveness to approved antivirals and candidate vaccines lowers human risk, but ongoing surveillance is critically needed.

Thomas P. Fabrizio
Ahmed Kandeil
Richard J. Webby
ResearchOpen Access23 Jul 2025
Nature Communications

Volume: 16, P: 1-12
The role of alpha-lactalbumin in modulating tryptophan metabolism and serotonin synthesis

Shannon Shoff
Xuan He
Carolyn M. Slupsky
ResearchOpen Access03 Jul 2025
npj Science of Food

Volume: 9, P: 1-14
Mode of Action of the Efferent Olivo-Cochlear Bundle on the Inner Ear

J. E. DESMEDT
P. MONACO
Research30 Dec 1961
Nature

Volume: 192, P: 1263-1265
Polymerisation and the solar neutrino problem

B. BANERJEE
S. M. CHITRE
K. S. V. SANTHANAM
Research08 Apr 1976
Nature

Volume: 260, P: 557
Galactic and Solar Nucleosynthesis

P. K. KURODA
M. W. ROWE
R. GANAPATHY
Research15 Oct 1966
Nature

Volume: 212, P: 241-243
Azaserine, A New Tumour-Inhibitory Substance: Antibiotic Studies of Azaserine

JOHN EHRLICH
LUCIA E. ANDERSON
JULIAN E. OYAAS
Research09 Jan 1954
Nature

Volume: 173, P: 72
Gene transfer and molecular cloning of the rat nerve growth factor receptor

Monte J. Radeke
Thomas P. Misko
Eric M. Shooter
Research18 Feb 1987
Nature

Volume: 325, P: 593-597
Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila

Qiang Yu
Hildur V. Colot
Michael Rosbash
Research01 Apr 1987
Nature

Volume: 326, P: 765-769
A roadmap for equitable reuse of public microbiome data

In this Consensus Statement, a consortium of microbiome scientists discuss current sequencing data sharing policies and propose the use of a Data Reuse Information (DRI) tag to promote equitable and collaborative data sharing.

Laura A. Hug
Roland Hatzenpichler
Alexander J. Probst
Reviews26 Sept 2025
Nature Microbiology

Volume: 10, P: 2384-2395
Respiratory viral infections awaken metastatic breast cancer cells in lungs

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.

Shi B. Chia
Bryan J. Johnson
James DeGregori
ResearchOpen Access30 Jul 2025
Nature

Volume: 645, P: 496-506
Phylogenetic divergence of GABA_B receptor signaling in neocortical networks over adult life

GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than rats, and a role for GABAB receptors in the anti-seizure profile of levetiracetam.

Max A. Wilson
Anna Sumera
Sam A. Booker
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-19
Alignment of Linear Biochemical Pathways Using Protein Structural Classification

Sridhar Hariharaputran
Thoralf Töpel
Ralf Hofestädt
ResearchOpen Access03 Jun 2008
Nature Precedings

P: 1
Prevalence of sexual dimorphism in mammalian phenotypic traits

Systemic dissection of sexually dimorphic phenotypes in mice is lacking. Here, Karp and the International Mouse Phenotype Consortium show that approximately 10% of qualitative traits and 56% of quantitative traits in mice as measured in laboratory setting are sexually dimorphic.

Natasha A. Karp
Jeremy Mason
Jacqueline K. White
ResearchOpen Access26 Jun 2017
Nature Communications

Volume: 8, P: 1-12

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