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The study of highly active electrodes in organic electrosynthesis remains an under-investigated component of the subfield. This work introduces a bottom-up route to prepare chitin-derived composite carbon aerogel electrodes (CCAEs), which can be directly used as electrodes in organic electrosynthesis systems.

The authors observed the electric field-induced generation and manipulation of topological spin textures at the monolayer limit using the topological magneto-optical effect.

Photocatalytic four-component reaction is a green and efficient synthetic strategy. Here, the authors report a series of covalent organic frameworks via the photocatalytic four-component reaction, which are used for photocatalysis.

The chemistry of phosphaalumenes featuring multiple bonds between phosphorus and aluminum remains largely unexplored. Here the authors report the synthesis of a phosphaalumene and characterize its activation of small molecules.

Precise and efficient CRISPR genome editing requires specialized delivery systems. Here, the authors develop Coomassie lipidoids that deliver purified adenine base editors into retinal tissues, making it possible to achieve robust genome editing with a defined, non-viral nanomedicine.

Reconciling broad substrate generality with high enantioselectivity remains a core limitation of enantioselective catalysis. In this study, the authors design a new-to-nature photoenzyme that unlocks enzymatic deracemization of structurally diverse allenes, an entropically disfavored process inaccessible to natural biocatalysts.

Extant representatives of the earliest land plant lineages adapt to various terrestrial habitats with structural and physiological innovations. Here the authors show a dual-coding gene in the moss Physcomitrella patens evolved from a hemerythrin gene, with effects on oil body biogenesis and dehydration resistance.

N-acetyltransferase 10 (NAT10) is an N⁴‐acetylcytidine (ac⁴C) writer, which catalyzes RNA acetylation at cytidine N⁴ position on RNAs. Here, the authors show that NAT10 catalyzes ac⁴C addition to a long non-coding RNA encoded by the oncogenic DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV), triggering viral lytic reactivation from latency, which promotes NAT10 recruitment of IFI16 mRNA, resulting in inflammasome activation.

The changing cellular, transcriptional, and genomic landscape of human lung aging can be characterized using single-cell RNA sequencing. Here, the authors show that lung aging is cell-type dyssynchronous, with alveolar epithelial and endothelial cells exhibiting the greatest changes in gene expression, transcriptional entropy, and a high level of somatic mutations.

Becker et. al developed a proteomic proximity labeling platform named POCA, which makes use of a photosensitizer for singlet oxygen production and protein capture in the presence of amine, enabling profiling of interactomes of proteins and lipids in living cells.

Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be potentially targeted for improved immunotherapy.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection.

Using survey data from 3,560 hospitals across the USA, AI implementation is shown to be spatially heterogeneous, influenced by the local context and institutional characteristics.

A molecular-level understanding of structural evolution upon electrochemical doping in organic mixed ionic-electronic conductors is required. A pronounced reduction in mass and thickness is observed in an n-type ladder polymer upon doping with protic cations owing to water expulsion.

A vascular graft enables wireless, real-time and continuous stenosis diagnosis and management.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Changes in penguin populations on the Antarctic Peninsula in recent decades have been linked to environmental factors such as sea ice. Here, the authors show that penguin colony change on Ardley Island, NW Antarctic Peninsula during the last 8,500 years was primarily driven by volcanic activity.

Endosomal sequestration of lipid-based nanoparticles is a barrier to delivery of nucleic acids. Here the authors test an array of cholesterol variants and perform in-depth investigation of nanoparticle shape, internal structure and intracellular trafficking.

Healing of infected tendons is hindered by mechanical dysfunction, tissue adhesion, and immune imbalance. Here, Li et al. develop a multifunctional Janus hydrogel with asymmetric adhesion, antibacterial properties, and pH-responsive release of tendon stem cell-derived exosomes for infected tendon repair.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Heart failure affects millions worldwide with limited treatment options. Here, the authors develop a biodegradable, self-powered vagus nerve stimulator that attenuates cardiac damage at different disease stages without requiring battery replacement or surgical removal.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

The current unbalance between the performance of n-type and p-type 2D transistors limits their applications for next-generation electronics. Here, the authors report the realization of high-performance 2D MoTe₂ p-type transistors by depositing metallic tellurium contacts via thermal evaporation.

Adaptive microwave surfaces can dynamically adjust their electromagnetic transmission to meet specific needs, being potentially useful in reconfigurable communication systems. Here, the authors use temperature induced break and reconstruction of hydrogen bonds to drive the orientational motion and charge mobility of an ionic liquid in a polymer leading to the controllable modulation of dielectric properties at microwave frequencies.

An amino-acid-encoded assembly strategy is developed for the synthesis of programmable chiral Solomon links, featuring tunable cavity dimensions and shapes. This template-free synthetic approach favours homochiral assembly over non-chiral or heterochiral pathways. The resulting interlocked molecules exhibit strong chiral amplification and exceptional enantioselective peptide recognition.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

This study tests how meaning shapes gaze in picture stories. Viewers fixate earlier and more on semantically informative objects in coherent image sequences, an effect captured by a language-model–based semantic saliency rather than visual salience.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell composition and cell states that correlate with clinical features are highlighted.

Single-cell transcriptomes from the fetal–maternal interface of six species of mammals reveal a conserved gene expression signature of invasive trophoblast, stepwise evolution of decidual stromal cell types and co-evolutionary patterns in cell–cell signalling.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

The authors report superconducting topological surface states (TSS) on MBE-grown Fe(Te,Se) films by high-resolution laser-ARPES. Near the FeTe limit, the surface state disappears due to an electron-correlation-driven topological transition associated with decoherence of the d_xy-orbital-derived bands.

The role of oxytocin in modulating astrocytes during stress behaviour is not fully understood. Here the authors show that in the amygdala, oxytocin modulates stress related behaviour by transient Gαi-dependent retraction of astrocytic processes, followed by enhanced neuronal sensitivity to extracellular potassium.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

A cohort study of schoolchildren in Yunnan Province, China showed that the two rounds of 400 mg albendazole treatment were highly effective against Ascaris lumbricoides, moderately effective for hookworm, and ineffective for Trichuris trichiura.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Pulmonary type 2 inflammation is associated with type 2 innate lymphoid cells. Here the authors use the Collaborative Cross mouse panel to show that ILC2 abundance during type 2 lung inflammation is different across the panel and identify free-fatty acid receptor 3 (Ffar3) as a gene responsible and show cytokine and ILC2 functional changes.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

Instabilities in chiral plasmas can amplify electromagnetic waves, raising the question of whether chiral solids behave similarly. Now a magneto-chiral instability is demonstrated in tellurium, observed as growing terahertz emission after photoexcitation.

Quark–antiquark annihilation measurements provide a precise determination of the ratio of down and up antiquarks within protons as a function of momentum, which confirms the asymmetry between the abundance of down and up antiquarks.

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

Metastatic cancer cells rely on metabolic flexibility to survive. Here, the authors show that metastatic breast cancer cells use lactate for mitochondrial oxidation via the CD147/MCT1/LDHB complex to sustain stemness and promote metastasis.

Existing Moiré materials are mostly van der Waals heterostructures. Here the authors show that hydrogen-bond adaptability allows spontaneous formation of twisted bilayer ice at magic angles in 2D confinement, establishing a new class of Moiré materials.

GALRs, receptors for the neuropeptide galanin, have emerged as potential therapeutic targets for inflammatory bowel disease. Here the authors report that GAL53, a long galanin peptide derived from non-mammalian vertebrates, alleviates induced colitis in preclinical models by engaging GALR2 and activating the β-arrestin2-biased signalling pathway.

Oat is an important food crop, but the genetic diversity within the gene pool remains unclear. Here, the authors report the analyses of worldwide diversity and population structure of hexaploid oat, and identify signatures of structural rearrangements within the germplasm collection.