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Showing 1–50 of 124 results

Advanced filters: Author: Pradeep Singh Clear advanced filters

Targeted design, synthesis, molecular dynamics, ADME and in –vitro anticancer assessment of oxo-tetrahydro-pyrimidin-benzenesulfonamide hybrids as potential BRAF^V600E inhibitors

Ankit Kumar Singh
Adarsh Kumar
Pradeep Kumar
ResearchOpen Access08 Oct 2025
Scientific Reports

Volume: 15, P: 1-16
A comparative investigation of ultrasonication and magnetic stirring methods for green synthesis of zinc oxide nanoparticles using Punica granatum peels

Komal Bhandari
Niki Nautiyal
Pradeep Kumar
ResearchOpen Access10 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
SuFEx-based antitubercular compound irreversibly inhibits Pks13

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Inna V. Krieger
Paridhi Sukheja
Case W. McNamara
Research30 Jul 2025
Nature

Volume: 645, P: 755-763
In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression

V. R. Sanal Kumar
Pradeep Kumar Radhakrishnan
Sanjay Singh
ResearchOpen Access11 Aug 2025
npj Microgravity

Volume: 11, P: 1-7
Author Correction: Optimizing ternary hybrid nanofluids using neural networks, gene expression programming, and multi-objective particle swarm optimization: a computational intelligence strategy

Tao Hai
Ali Basem
H. Maleki
Amendments and CorrectionsOpen Access15 Sept 2025
Scientific Reports

Volume: 15, P: 1
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Usage of serpentine injector for hydrogen mixing at combustion chamber of scramjet engine via a computational study

Ahmed Mir
Rassol Hamed Rasheed
Lioua Kolsi
ResearchOpen Access16 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

Pradeep K. Singh
Amy L. Schaefer
E. P. Greenberg
Research12 Oct 2000
Nature

Volume: 407, P: 762-764
Allele-specific primer based identification of dimeric alpha-amylase inhibitor

Pradeep Sharma
Pooja Sharma
S. S. Singh
MultimediaOpen Access31 Jan 2011
Nature Precedings

P: 1
Usage of double injector for efficient mixing of the fuel behind the ramp injector at supersonic combustion chamber

Ihab Omar
Mohamed R. El-Sharkawy
S. Arman Abodollahi
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Progress and challenges towards eliminating vertical transmission of HIV in India

Pradeep Kumar
Chinmoyee Das
Shobini Rajan
ResearchOpen Access11 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Rooting behaviour and soil properties in different bamboo species of Western Himalayan Foothills, India

R. Kaushal
Indra Singh
J. Durai
ResearchOpen Access18 Mar 2020
Scientific Reports

Volume: 10, P: 1-17
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrate their efficacy and present the AsnEDA bound immunoproteasome cryo-EM structure.

Ruda de Luna Almeida Santos
Lin Bai
Gang Lin
ResearchOpen Access22 Nov 2017
Nature Communications

Volume: 8, P: 1-11
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Investigation of unswept ramp system with lobe shape nozzle for fuel mixing of hydrogen jet at a scramjet engine

Ihab Omar
Mohamed R. El-Sharkawy
S. Arman Abodollahi
ResearchOpen Access09 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
Mechanically controlled multifaceted dynamic transformations in twisted organic crystal waveguides

Crystals with mechanical responses are of interest, but often only one or two dynamic motions can be achieved with one crystal. Here, the authors report a combination of dynamic movements in naturally twisted optical waveguiding microcrystals.

Mehdi Rohullah
Vuppu Vinay Pradeep
Rajadurai Chandrasekar
ResearchOpen Access13 May 2024
Nature Communications

Volume: 15, P: 1-10
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia

Kumarasamy Thangaraj and colleagues describe the association of a 25-bp deletion in MYBPC3 with heritable cardiomyopathies in Indian populations. They find a high prevalence (4–8%) of the deletion in surveyed Indian populations and an absence of the deletion in surveyed populations outside of Southeast Asia.

Perundurai S Dhandapany
Sakthivel Sadayappan
Kumarasamy Thangaraj
Research18 Jan 2009
Nature Genetics

Volume: 41, P: 187-191
Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha

Salam Pradeep Singh
Khumukcham Nongalleima
Dinabandhu Sahoo
ResearchOpen Access06 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Origins of complexity in the rheology of Soft Earth suspensions

Regarding the failure and flow of wet soil, a question that remains is how soil material composition influences rheology. Based on Soft Earth suspension flow experiments, the authors discover a continuous transition from frictional-to-cohesive rheology recreating all complex behaviors reported for natural soil slurries.

Shravan Pradeep
Paulo E. Arratia
Douglas J. Jerolmack
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-10
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification

de Vries, Conomos, Singh and Nicholson et al. identify two additional loci associated with coronary artery calcification (ARSE and MMP16) via a genome-wide association study in 22,400 participants from multiple ancestral groups and prove that ARSE is a mediator of vascular smooth muscle cell calcification and phenotype switching.

Paul S. de Vries
Matthew P. Conomos
Rajeev Malhotra
Research04 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1159-1172
Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu

In this work, the authors report that proteins/polypeptides with diverse sequences and structures can form liquid condensates, however with varying phase regimes and different modes of intermolecular interactions, spanning from electrostatic, hydrophobic and H-bond.

Manisha Poudyal
Komal Patel
Samir K. Maji
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-21
Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response

Aging is associated with a loss of blood stem cell fitness in part due to defects in stem cell-supportive niches. Here, the authors demonstrate that restoring niche function by treatment with Netrin-1 is able to rejuvenate aged blood stem cells.

Pradeep Ramalingam
Michael C. Gutkin
Jason M. Butler
ResearchOpen Access10 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Detection of viral RNAs at ambient temperature via reporter proteins produced through the target-splinted ligation of DNA probes

An assay leveraging the target-specific splinted ligation of DNA probes to generate expression cassettes for the cell-free synthesis of reporter proteins accurately detects nucleic acids at ambient temperature.

Elizabeth A. Phillips
Adam D. Silverman
William J. Blake
ResearchOpen Access04 May 2023
Nature Biomedical Engineering

Volume: 7, P: 1571-1582
Exploring the effectiveness of adaptive randomized sine cosine algorithm in wind integrated scenario based power system optimization with FACTS devices

Sunilkumar P. Agrawal
Pradeep Jangir
Mohammad Khishe
ResearchOpen Access27 Feb 2025
Scientific Reports

Volume: 15, P: 1-34
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Glycerol-3-phosphate mediates rhizobia-induced systemic signaling in soybean

Movement of glycerol-3-phosphate (G3P) promotes systemic resistance following local pathogen infections. Here the authors show that rootward movement of shoot-synthesized G3P occurs in response to root-recognition of incompatible rhizobia and promotes exclusion of non-desirable bacteria in roots.

M. B. Shine
Qing-ming Gao
Aardra Kachroo
ResearchOpen Access22 Nov 2019
Nature Communications

Volume: 10, P: 1-13
A component of innate immunity prevents bacterial biofilm development

Pradeep K. Singh
Matthew R. Parsek
Michael J. Welsh
Research30 May 2002
Nature

Volume: 417, P: 552-555
Seismic wave reflection characteristics and wave-induced fluid flow in unsaturated porous solid

Manjeet Kumari
Pradeep Kaswan
Milkias Berhanu
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-28
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Process parameter optimization for minimizing overcut in abrasive waterjet deep hole drilling of SS 316L

J. Bharani Chandar
N. Lenin
Choon Kit Chan
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-25
Incidence of post vitrectomy endophthalmitis in India – A multicentric study by VRSI study Group

Payal Naresh Shah
Divyansh K. Mishra
Abhishek Kothari
Research08 Feb 2023
Eye

Volume: 37, P: 2915-2920
In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075

The bacterial pathogen Acinetobacter baumannii has evolved resistance to many antibiotics, including carbapenems. Here, Wu et al. show that the carbapenemase Oxa-23 interacts with the outer membrane porin CarO in an A. baumanniiisolate, indicative of porin-localised antibiotic inactivation.

Xia Wu
Juan D. Chavez
James E. Bruce
ResearchOpen Access11 Nov 2016
Nature Communications

Volume: 7, P: 1-14
Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Pradeep Kumar
Amit Kumar Singh
Ovidiu Pop
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum

Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%.

Prem Prakash
Mohammad Zeeshan
Pawan Malhotra
ResearchOpen Access16 Nov 2017
Nature Communications

Volume: 8, P: 1-12
Identification of quantitative trait nucleotides for grain quality in bread wheat under heat stress

Latief Bashir
Neeraj Budhlakoti
Sundeep Kumar
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Expression of barrier proteins in the skin lesions and inflammatory cytokines in peripheral blood mononuclear cells of atopic dogs

Sarita Kanwal
Shanker K. Singh
Satish K. Garg
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-7
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
IoT-based automated system for water-related disease prediction

Bhushankumar Nemade
Kiran Kishor Maharana
Ben Othman Soufiene
ResearchOpen Access27 Nov 2024
Scientific Reports

Volume: 14, P: 1-30
Global estimates on the number of people blind or visually impaired by age-related macular degeneration: a meta-analysis from 2000 to 2020

João M. Furtado
Jost B. Jonas
Rupert R. A. Bourne
ResearchOpen Access04 Jul 2024
Eye

Volume: 38, P: 2070-2082
Cell free DNA from respiratory pathogens is detectable in the blood plasma of Cystic Fibrosis patients

Sara L. Rassoulian Barrett
Elizabeth A. Holmes
Stephen J. Salipante
ResearchOpen Access23 Apr 2020
Scientific Reports

Volume: 10, P: 1-6
A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic and clinical information.

Zhijian Yang
Ilya M. Nasrallah
Balebail Ashok Raj
ResearchOpen Access03 Dec 2021
Nature Communications

Volume: 12, P: 1-15
Prevalence of malaria in two highly endemic Community Health Centers in the Bastar district, Chhattisgarh showing mixed infections with Plasmodium species

Sri Krishna
Ajay Yadav
Neeru Singh
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
Optimizing ternary hybrid nanofluids using neural networks, gene expression programming, and multi-objective particle swarm optimization: a computational intelligence strategy

Tao Hai
Ali Basem
H. Maleki
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-26
Author Correction: Integrated approach for studying bioactive compounds from Cladosporium spp. against estrogen receptor alpha as breast cancer drug target

Satish Anandan
Hittanahallikoppal Gajendramurthy Gowtham
Daniel Glossman‑Mitnik
Amendments and CorrectionsOpen Access09 Feb 2023
Scientific Reports

Volume: 13, P: 1-2
A hybrid slime mold enhanced convergent particle swarm optimizer for parameter estimation of proton exchange membrane fuel cell

Mohammad Aljaidi
Sunilkumar P. Agrawal
Mohammad Khishe
ResearchOpen Access08 Mar 2025
Scientific Reports

Volume: 15, P: 1-30
A two phase differential evolution algorithm with perturbation and covariance matrix for PEMFC parameter estimation challenges

Mohammad Aljaidi
Pradeep Jangir
Mohammad Khishe
ResearchOpen Access13 Mar 2025
Scientific Reports

Volume: 15, P: 1-28
Fasting-induced FOXO4 blunts human CD4⁺ T helper cell responsiveness

In a screen of peripheral blood cells from fasted or fed individuals, Han et al. identify FOXO4 and its target FKBP5 as fasting-induced modulators of CD4⁺ T helper cell responsiveness.

Kim Han
Komudi Singh
Michael N. Sack
Research15 Mar 2021
Nature Metabolism

Volume: 3, P: 318-326

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