Nature Search

Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic

The O139 Vibrio cholerae serogroup emerged in the 1990s and spread rapidly but did not become globally dominant. Here, the authors describe the genomic epidemiology of this strain and identify changes in virulence and antimicrobial resistance characteristics that they hypothesise may have contributed to its decline.

Thandavarayan Ramamurthy
Agila Kumari Pragasam
Ankur Mutreja
ResearchOpen Access05 Jul 2022
Nature Communications

Volume: 13, P: 1-10
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

Gene therapy in the inner ear achieves unprecedented recovery of hearing and balance behavior in Usher syndrome mice.

Bifeng Pan
Charles Askew
Gwenaëlle S Géléoc
Research06 Feb 2017
Nature Biotechnology

Volume: 35, P: 264-272
A small molecule mitigates hearing loss in a mouse model of Usher syndrome III

A small molecule identified from high-throughput screening and optimization specifically stabilizes a disease-linked CLRN1 protein, delivering it to its site of action at the plasma membrane and preserving hearing in a new mouse model for Usher syndrome type III.

Kumar N Alagramam
Suhasini R Gopal
Yoshikazu Imanishi
Research25 Apr 2016
Nature Chemical Biology

Volume: 12, P: 444-451
Profound, prelingual nonsyndromic deafness maps to chromosome 10q21 and is caused by a novel missense mutation in the Usher syndrome type IF gene PCDH15

Lance Doucette
Nancy D Merner
Terry-Lynn Young
Research24 Dec 2008
European Journal of Human Genetics

Volume: 17, P: 554-564
Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III

Ruishuang Geng
Akil Omar
Kumar N. Alagramam
ResearchOpen Access18 Oct 2017
Scientific Reports

Volume: 7, P: 1-15
Erratum: Profound, prelingual nonsyndromic deafness maps to chromosome 10q21 and is caused by a novel missense mutation in the Usher syndrome type IF gene PCDH15

Lance Doucette
Nancy D Merner
Terry-Lynn Young
Amendments and Corrections24 Sept 2009
European Journal of Human Genetics

Volume: 17, P: 1363
Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae

Cannulae are heat-resistant protein nanotubes found on the surface of thermophilic archaea. Here, the authors report the structures of cannulae at the atomic level with insight into their high stability and mechanism of assembly, which has potential impact for biomaterials design.

Mike Sleutel
Ravi R. Sonani
Vincent P. Conticello
ResearchOpen Access13 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Gene therapy approaches for prevention of retinal degeneration in Usher syndrome

D S Williams
A Chadha
D Gibbs
News05 Jan 2017
Gene Therapy

Volume: 24, P: 68-71
A comprehensive guide to pilus biogenesis in Gram-negative bacteria

Pili are crucial virulence factors in many Gram-negative pathogens; these surface structures enable bacteria to interact with, and attach to structures in, their environment and can also facilitate horizontal gene transfer. In this Review, Waksmanet al. examine recent advances in our structural understanding of various pilus systems in Gram-negative bacteria and discuss their functional implications.

Manuela K. Hospenthal
Tiago R. D. Costa
Gabriel Waksman
Reviews12 May 2017
Nature Reviews Microbiology

Volume: 15, P: 365-379
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa

Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which increases drag and prevents sinking. The pili also enrich microcystin and co-localize with iron-enriched extracellular matrix components, suggesting a vital role in bloom proliferation.

John G. Ricca
Holly A. Petersen
Fengbin Wang
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-13
A detailed clinical and molecular survey of subjects with nonsyndromic USH2A retinopathy reveals an allelic hierarchy of disease-causing variants

Eva Lenassi
Ajoy Vincent
Andrew R Webster
ResearchOpen Access04 Feb 2015
European Journal of Human Genetics

Volume: 23, P: 1318-1327
Electroretinography Reveals Difference in Cone Function between Syndromic and Nonsyndromic USH2A Patients

Jesse D. Sengillo
Thiago Cabral
Stephen H. Tsang
ResearchOpen Access11 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Giant retinal tear and retinal detachment with underlying retinitis pigmentosa and hearing loss

Robert Y Kim
Steven D Schwartz
Robert J Cooling
Research01 Nov 1996
Eye

Volume: 10, P: 697-700
Radio properties of BL Lac type objects

D. R. Altschuler
J. F. C. Wardle
Research22 May 1975
Nature

Volume: 255, P: 306-310
Natural history of long-COVID in a nationwide, population cohort study

The long-term natural history of long-COVID is not well understood. In this population-based cohort study from Scotland, the authors describe symptom prevalence and health-related quality of life up to 18 months after a positive SARS-CoV-2 test and compare with matched test-negative controls.

Claire E. Hastie
David J. Lowe
Jill P. Pell
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-10
Secretion systems in Gram-negative bacteria: structural and mechanistic insights

In this Review, Waksman and colleagues describe the structural and mechanistic details of the six secretion systems (types I–VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone–usher pathway and the curli biogenesis machinery. They discuss both conserved and divergent properties of these systems and their potential as targets of novel antibacterial compounds.

Tiago R. D. Costa
Catarina Felisberto-Rodrigues
Gabriel Waksman
Reviews15 May 2015
Nature Reviews Microbiology

Volume: 13, P: 343-359
Self-splicing RNA circularization facilitated by intact group I and II introns

RNA circularization is vital for circRNA therapeutics. Here, authors present two in vitro methods—PIET and CIRC—where CIRC employs intact self-splicing introns to generate circRNAs efficiently, and enables large circRNA generation, broadening the circRNA platform’s potential.

Yong Shen
Bohan Li
Wensheng Wei
ResearchOpen Access10 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank

Bone marrow adipose tissue accounts for almost 10% of human fat mass, but its roles remain unclear. Here, Xu et al. identify more than 45 diseases linked to marrow adiposity in over 48,000 people, including causal roles in musculoskeletal disease.

Wei Xu
Ines Mesa-Eguiagaray
William P. Cawthorn
ResearchOpen Access23 Sept 2025
Nature Communications

Volume: 16, P: 1-22
USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans

Schwaller et al. show that the USH2A protein, present in Meissner’s corpuscles, is necessary in humans and mice to perceive tiny vibrations. USH2A may facilitate force transfer to mechanoreceptors as the fingertip probes rough surfaces.

Fred Schwaller
Valérie Bégay
Gary R. Lewin
Research07 Dec 2020
Nature Neuroscience

Volume: 24, P: 74-81
Vaccination with Acinetobacter baumannii adhesin Abp2D provides protection against catheter-associated urinary tract infection

Acinetobacter baumannii is a multi-drug-resistant pathogen of urgent international concern. Here, the authors develop a protein subunit vaccine which prevents A. baumannii catheter-associated urinary tract infections in mice by inhibiting Abp2D, a key adhesive virulence factor.

Morgan R. Timm
Kevin O. Tamadonfar
Scott J. Hultgren
ResearchOpen Access09 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Optical variability of PKS0048-097

P. D. USHER
D. R. KOLPANEN
J. T. POLLOCK
Research29 Nov 1974
Nature

Volume: 252, P: 365
Dublin Observatory

T. R. R.
Research06 Apr 1871
Nature

Volume: 3, P: 445-446
Evolution of the 3′, 5′ internucleotide bond (reply)

R. H. SARMA
M. M. DHINGRA
Research01 Apr 1979
Nature

Volume: 278, P: 582
Transcriptional diversification in a human-adapting zoonotic pathogen drives niche-specific evolution

Ghosh et al study transcriptional diversification in the human-adapting zoonotic pathogen, Bordetella hinzii, as it evolved during the course of a chronic infection, revealing plasticity and niche-specific functional adaptation to the blood and gastrointestinal compartments.

Soma Ghosh
Chao-Jung Wu
John P. Dekker
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-13
The usherin mutation c.2299delG leads to its mislocalization and disrupts interactions with whirlin and VLGR1

The c.2299delG mutation in usherin causes loss of hearing and vision. Here, the authors show in a mouse model of this disease that the expression of mutant usherin leads to retinitis pigmentosa and structural defects in the photoreceptor cilium associated with mislocalization of VLGR1 and WHRN.

Lars Tebbe
Maggie L. Mwoyosvi
Muna I. Naash
ResearchOpen Access21 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Genomic surveillance identifies potential risk factors for SARS-CoV-2 transmission at a mid-sized university in a small rural town

Kimberly R. Andrews
Daniel D. New
Carolyn J. Hovde
ResearchOpen Access16 May 2023
Scientific Reports

Volume: 13, P: 1-15
Discovery of bioactive microbial gene products in inflammatory bowel disease

A computational system termed MetaWIBELE (workflow to identify novel bioactive elements in the microbiome) is used to identify microbial gene products that are potentially bioactive and have a functional role in the pathogenesis of inflammatory bowel disease.

Yancong Zhang
Amrisha Bhosle
Eric A. Franzosa
Research25 May 2022
Nature

Volume: 606, P: 754-760
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

Lynette Cegelski
Jerome S Pinkner
Scott J Hultgren
Research25 Oct 2009
Nature Chemical Biology

Volume: 5, P: 913-919
Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission

Emerging SARS-CoV-2 variants of concern were detected early and multiple cases of virus spread not captured by clinical genomic surveillance were identified using high-resolution wastewater and clinical sequencing.

Smruthi Karthikeyan
Joshua I. Levy
Rob Knight
ResearchOpen Access07 Jul 2022
Nature

Volume: 609, P: 101-108
The role of molecular genetics in the prenatal diagnosis of retinal dystrophies

K Evans
C Y Gregory
S S Bhattacharya
Research01 Jan 1995
Eye

Volume: 9, P: 24-28
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18

J. Parkhill
G. Dougan
B. G. Barrell
Research25 Oct 2001
Nature

Volume: 413, P: 848-852
Radio brightness distribution of 3C273

R. G. CONWAY
D. STANNARD
Research22 May 1975
Nature

Volume: 255, P: 310-312
Disease asymmetry and hyperautofluorescent ring shape in retinitis pigmentosa patients

Ruben Jauregui
Lawrence Chan
Stephen H. Tsang
ResearchOpen Access25 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
Pb(II)-catalysed cleavage of the sugar–phosphate backbone of yeast tRNA^Phe—implications for lead toxicity and self-splicing RNA

R. S. Brown
B. E. Hingerty
A. Klug
Research01 Jun 1983
Nature

Volume: 303, P: 543-546
Regionally enriched rare deleterious exonic variants in the UK and Ireland

The genetic variants present in humans often reflect the geographical origins of their ancestors. This study shows that people from different UK regions tend to carry different rare variants in their exomes, with potential biomedical consequences.

Mihail Halachev
Viktoria-Eleni Gountouna
James F. Wilson
ResearchOpen Access02 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Myosin from Cross-reinnervated Cat Muscles

A. G. WEEDS
D. R. TRENTHAM
A. J. BULLER
Research18 Jan 1974
Nature

Volume: 247, P: 135-139
Congenital hearing loss

Viral infections during pregnancy and acquired genetic mutations account for the majority of cases of congenital hearing loss. Early detection of this chronic condition, through neonatal hearing screening programmes, greatly benefits the cognitive and social development of the child.

Anna M. H. Korver
Richard J. H. Smith
An N. Boudewyns
Reviews12 Jan 2017
Nature Reviews Disease Primers

Volume: 3, P: 1-17
Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

D. P. Kelsell
J. Dunlop
I. M. Leigh
Research01 May 1997
Nature

Volume: 387, P: 80-83
Bardet–Biedl syndrome is linked to DNA markers on chromosome 11 q and is genetically heterogeneous

Mark Leppert
Lisa Baird
Richard Alan Lewis
Research01 May 1994
Nature Genetics

Volume: 7, P: 108-112
In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa

Retinitis pigmentosa (RP) is the most common type of inherited retinal dystrophy without effective treatments. Here, authors apply prime editing (PE) system to correct the point mutation in a preclinical RP mouse model. In vivo treatment achieves genome editing and restores mice vision.

Yidian Fu
Xiaoyu He
Zhi Yang
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Deep learning and genome-wide association meta-analyses of bone marrow adiposity in the UK Biobank

Bone marrow adipose tissue accounts for over 10% of human fat mass. Here, Xu et al. use deep learning to measure marrow adiposity in over 45,000 people, and identify genes associated with altered bone marrow adiposity.

Wei Xu
Ines Mesa-Eguiagaray
William P. Cawthorn
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-19
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications

Irene Perea-Romero
Gema Gordo
Carmen Ayuso
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

Brenda L. Bass
Thomas R. Cech
Research26 Apr 1984
Nature

Volume: 308, P: 820-826
Combining targeted panel-based resequencing and copy-number variation analysis for the diagnosis of inherited syndromic retinopathies and associated ciliopathies

Iker Sanchez-Navarro
Luciana R. J. da Silva
Carmen Ayuso
ResearchOpen Access27 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Urinary tract infections: epidemiology, mechanisms of infection and treatment options

Urinary tract infections (UTIs) pose a severe public health problem and are caused by a range of pathogens. In this Review, Hultgren and colleagues discuss how basic science studies are elucidating the molecular mechanisms of UTI pathogenesis and how this knowledge is being used for the development of novel clinical treatments for UTIs.

Ana L. Flores-Mireles
Jennifer N. Walker
Scott J. Hultgren
Reviews08 Apr 2015
Nature Reviews Microbiology

Volume: 13, P: 269-284
Morell's Geometry

J. R. MORELL
Research06 Apr 1871
Nature

Volume: 3, P: 446
Formaldehyde in Rain Water

N. R. DHAR
ATMA RAM
Research27 Aug 1932
Nature

Volume: 130, P: 313-314
Harnessing database-supported high-throughput screening for the design of stable interlayers in halide-based all-solid-state batteries

All-solid-state lithium metal batteries face interfacial instability challenges. Here, authors develop a computational screening framework to identify Li₃OCl as a stable interlayer between Li₃InCl₆ electrolyte and the Li metal electrode, improving the capacity retention of all-solid-state batteries.

Longyun Shen
Zilong Wang
Francesco Ciucci
ResearchOpen Access17 Apr 2025
Nature Communications

Volume: 16, P: 1-9

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