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Current calcium-sensitive probes based on red fluorescent proteins are unsuitable for two-photon excitation at the near-infrared wavelengths commonly used for green fluorescent probes. Wu et al. use a structure-guided approach to engineer a red fluorescent probe with optimal two-photon excitation at these wavelengths.

Exploiting photon–phonon coupling in nanoscale silicon waveguides could enable a host of powerful features in photonic devices. Using a hybrid photonic–phononic waveguide structure, Shin et al. show stimulated Brillouin scattering nonlinearities and gain, which offers new on-chip signal-processing abilities.

The excitation of metal nanoparticles with light can lead to localized surface plasmon resonances, capable of driving chemical reactions in bound species. Here, the authors elucidate this mechanism and suggest that future plasmonic catalysts may be able to selectively activate specific chemical bonds.

Non-classical vibrations are generated and transmitted along a mechanical waveguide, providing a platform for distributing quantum information and realizing hybrid quantum devices using phonons in a solid-state system.

Topological systems are limited to low dimensions. Here, authors unveil the topology of orbital angular momentum in two-dimensional skyrmion textures, connecting them to ’t Hooft-Polyakov magnetic monopoles, and in higher dimensions, uncovering a topological spectrum of 17000 invariants.

By exploiting the long-lived phonon modes in nanoscale mechanical resonators, a quantum memory that operates around the standard telecom wavelength of 1,550 nm is realized on a silicon platform.

Monolayer transition metal dichalcogenides host excitons, bound electron-hole pairs that play a pivotal role in optoelectronic applications relying on strong light-matter interaction. Here, the authors unveil the spectroscopic signature of boson scattering of two-dimensional excitons in monolayer WSe₂.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Understanding the confinement and transport of excitons in low dimensional systems will aid the development of next generation photovoltaics. Via photophysical studies Ni et al. observe 'quantum cutting' in 0D metal-organic hybrid materials based on methylammonium bismuth halide (CH₃NH₃)3Bi₂I₉.

A skyrmion is a topologically stable field configuration. A non-local skyrmion, which has been hitherto elusive in condensed-matter physics, is realized by using entangled photons with a non-trivial topology. The connection between the notions of topology and entanglement is investigated, revealing topological invariance even when entanglement is fragile.

The West Antarctic Ice Sheet responded to different natural forcing mechanisms than the East Antarctic Ice Sheet through the mid-Pliocene due to a greater sensitivity to oceanic feedbacks, according to iceberg-rafted debris records and ice-sheet modelling experiments.

Recent work reported a non-local quantum entangled state of photons with skyrmionic topology. Here the authors demonstrate theoretically and experimentally that topological properties of this system are resilient to noise, even as entanglement measures decay, and elucidate the mechanisms behind this robustness.

Unlike conventional lasers that require a uniform resonant cavity to operate, random lasers use a highly disordered gain medium in which scattering is dominant. Hokr et al. report Raman lasing from a bulk three-dimensional disordered medium whose intensity exceeds that of other random lasers by many orders of magnitude.

FRB 20221022A, detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst project, shows a pronounced change in polarization during the burst, providing important clues into the nature of the source.

Researchers report the first direct measurements of the wavefunction and Dirac distributions for polarization states of light. Their implementation determines the general description of the pure state of a qubit. This technique is simple, fast and general, and has an advantage over the conventional approach of performing quantum state tomography.

Despite their intriguing electronic features and promising functional properties, phosphinines remain underexplored because their selective modification is difficult. In this work, the authors demonstrate that halogen–zinc exchanges provide an efficient route to functionalized λ⁵-phosphinines, operating under mild, functional-group-tolerant conditions and enabling access to diverse architectures with notable fluorescence characteristics.

Near-infrared (NIR) fluorophores have attracted interest for bioimaging; yet availability, biocompatibility and application can be an issue. Here, the authors report on the development of Egyptian Blue nanosheets with high NIR fluorescence and photostability demonstrating bioimaging applications in vivo.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The low thermal conductivity in filled skutterudites has been ascribed to rattling atoms inducing a phonon glass. Experimental evidence now shows that the phonon glass description is incorrect, and provides essential insight for the development of microscopic models aimed at describing the thermoelectric properties of these materials.

Cytoplasmic flows in the fruit fly oocyte can reorganize cellular components. These structured vortical flows arise through self-organizing dynamics of microtubules, molecular motors and cytoplasm.

CaBLAM is a bioluminescent genetically encoded calcium indicator that delivers high-contrast signals as shown in cell culture, in the in vivo mouse brain and in zebrafish larvae.

The interaction of water molecules with a protein results in a frictional force that influences protein conformational dynamics and folding, though the nature of the protein also influences the friction. Here, the authors use molecular simulations to examine the origin of this protein contribution.

Line-scan Brillouin microscopy enables fast 3D imaging of mechanical properties with low phototoxicity, as shown for Drosophila and mouse embryos, as well as ascidians.

Analysis of a fossilized front flipper of the Jurassic ichthyosaur Temnodontosaurus that preserves details of soft tissue indicates the presence of a serrated trailing edge that would have reduced noise generated while swimming, enabling stealth hunting and hiding from predators.

A thin liquid coating on a fibre can break up into droplets due to the Plateau–Rayleigh instability, as for instance on a spider web. Here, Haefner et al. show that the growth rate of the droplet undulations strongly depends on the fibre–liquid boundary condition and slip accelerates the instability.

Raman microscopes suffer from the compromise between speed and spectral information and are often unsuited for fibre beam delivery. Karpf et al.overcome these limitations using continuous-wave rapidly wavelength-swept probe lasers and a short-duty-cycle actively modulated pump laser in an all-fibre setup.

Brillouin scattering microscopy is prone to artefacts and inconsistencies. This Consensus statement provides recommendations for measuring and reporting relevant parameters with the aim of standardizing protocols and improving the comparability of studies.

To turn on and obtain emission from lanthanide-doped insulating nanoparticles, an electrical excitation pathway coupling them to organic optical molecules to form nanohybrids is described, enabling tunable electroluminescence properties of LEDs fabricated from such materials.

Melting at the base of the Greenland Ice Sheet is often disregarded as a source of quantifiable mass loss. In this study, the authors find the basal mass loss is equivalent to 8% of the ice sheet’s present imbalance, and that the loss of mass from basal melt is likely to increase in the future.

Donor exciton delocalization and its impact on photovoltaic performance of organic solar cells remains less explored. Here, the authors found that delocalized excitons are formed in aggregates of the donor polymer D18, and that these delocalized excitons mediate charge generation in solar cells.

Knotted lines representing torus knot and figure-eight knot are produced in the polarization profile of optical beams, leading to a topological characterization of the structure of the polarization field.

The observation of pulsar emission at various orbital phases of a companion star probes the diverse magnetic structure in a binary system, and exhibits varying polarization behavior, akin to that observed in certain fast radio bursts.

Biomolecular condensates (BCs) are ubiquitous compartments that regulate key functions in cells. Authors demonstrate that phase separation is suppressed with glycine by using model heterotypic condensates composed of nucleophosmin 1 and ribosomal ribonucleic acid.

Stimulated Raman scattering (SRS) microscopy is used to directly visualize lipids in cells and model organisms, and facilitates screening for genes involved in fat storage.

Long-wavelength luminescence from boron-based cations is typically hindered by both intrinsic instability and pronounced non-radiative decay. Now a triadic design that integrates a non-Kekulé polycyclic aromatic hydrocarbon framework, a charge-localizing carbodicarbene ligand and counterion-directed assembly enables stable borenium ions with tunable red-to-near-infrared emission in the solid state.

Coherently interfacing microwave and optical radiation at the single photon level is an outstanding challenge in quantum technologies. Here, the authors show bi-directional on-chip conversion between MW and optical frequencies exploiting piezoelectric actuation of a gallium phosphide optomechanical resonator.

Antiskyrmions are topological spin textures with negative vorticity. Like skyrmions, they have considerable technological promise, but have only been stabilised in Heusler compounds. Here, Heigl et al. succeed in stabilising first and second order antiskyrmions in a new class of materials.

Here the authors identify a generic coupling in phase-separated liquids between motility and phase equilibria perturbations: phase-separated droplets swim to their dissolution. This suggests alternative transport mechanism for biomolecular condensates.

The potential of organic light-emitting diodes (OLEDs) for solid-state lighting applications is limited by the need to develop efficient blue emitters. Here, the authors utilize a unicolored phosphor-sensitized fluorescence strategy to demonstrate efficient sky-blue OLEDs with enhanced lifetime.