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Gatemons, or gate-tunable transmons, are superconducting qubits based on hybrid Josephson junctions, which typically use extended quantum conductors as weak links. Here the authors report a gatemon made with a carbon-nanotube-based junction, showing improved coherence time compared to graphene-based devices.

Evidence suggests that fibrous aggregates of protein tau may be the proximal cause of Alzheimer’s disease. Here, using atomic structures of tau fibrils from brains of people with Alzheimer’s disease, the authors have found small-molecule drug leads that disaggregate tau fibrils in vitro.

Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects on synapses in live human brain slice cultures.

A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

The change in the electrical properties of a ferromagnetic under the influence of a magnetic field depends strongly on field orientation. Marti et al.now show that this so-called anisotropic magnetoresistance is also evident in antiferromagnetic semiconductors, making them useful in spintronics.

Whether temporal code and rate code have different rates of representational drift over extended periods is not fully understood. Using ultraflexible electrodes, here authors show that temporal codes extracted from fast spiking patterns reduce visual representational drift compared to firing rates over 15 consecutive days in mice.

Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some aspects of sporadic late onset AD.

The centriole exhibits an evolutionarily conserved 9-fold radial symmetry that stems from a cartwheel containing vertically stacked ring polymers that harbor 9 homodimers of the protein SAS-6. Here the authors show how dual properties inherent to surface-guided SAS-6 self-assembly possess spatial information that dictates correct scaffolding of centriole architecture.

The authors report observation of tunnelling magnetoresistance in an all-antiferromagnetic tunnel junction consisting of Mn₃Sn/MgO/Mn₃Sn, laying the foundation for the development of ultrafast and efficient spintronic devices using antiferromagnets.

The structure-function relationships of a β-helix, a folding motif formed by parallel β-strands arranged in a helical repetitive pattern, remain poorly understood and underexploited. Here, the authors reconstitute a protein β-helix by design from an elementary sequence of 18 amino acids, which self-assembles into a self-contained multifunctional motif exhibiting a range of biological functions.

Life-threatening vascular tumors can be associated with uncontrolled activity of the guanine nucleotide-binding protein subunit alpha (Gαq). Here, the authors develop a murine model for these tumors and show that MEK inhibition prevents formation of vascular lesions and improves survival.

The endocardium lines the interior of the heart chambers and has been debated as a source of hematopoietic lineages. Here they show that the endocardium may act as a source of, and resident tissue for, hematopoietic stem and progenitor cells in zebrafish, providing evidence for diversity in origins and residences of hematopoietic cells.

The authors image non-equilibrium exciton phase-transition dynamics in moiré superlattices, revealing how strong long-range dipolar repulsion freezes the motion of the Mott insulator over a timescale of tens of nanoseconds.

Here they show that ATF7IP/SETDB1-mediated epigenetic programming governs T lymphoid progenitor trafficking and differentiation, providing important insights into the pathogenesis of human T lymphoid diseases.

Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

Concentrator photovoltaics achieve high efficiency but have so far been impractical for use on rooftops. Here, Price et al. develop a flat-panel concentrating photovoltaic system based on a triple-junction solar cell that operates at fixed tilt over a full day with >30% peak efficiency.

Scanning tunnelling microscopy imaging of the correlated phases of magic-angle twisted trilayer graphene shows marked signatures of interaction-driven spatial symmetry breaking.

How axolotl salamanders know what portion of the limb to regenerate remains a mystery. In this article, the authors show that precise retinoic acid degradation is critical for instructing regeneration of the appropriate limb segment.

Increasing memory performance and density will require new breakthroughs in atomic-scale technology and three-dimensional device architectures. Here, the authors demonstrate a memory just 3 Å thick that can be stacked by exploiting the atomically thin edge of monolayer graphene.

Mechanisms that regulate epithelial bending mainly link to cell shape changes, for example, the formation of wedge shaped cells. Here, the authors identify a different cell behaviour in the salivary glands and teeth where initial invagination arises by a coordinated vertical cell movement.

An unusual family of bifunctional terpene synthases has been identified in which a prenyltransferase assembles 5-carbon precursors to form C20 geranylgeranyl diphosphate (GGPP), which is then converted into a polycyclic product by a cyclase. Here, the authors report the cryoEM structure of a 495-kD bifunctional terpene synthase, variediene synthase from Emericella variecolor, in which GGPP is not channeled intramolecularly, but can be channeled intermolecularly to a non-native cyclase.

Three-dimensional imaging of the fetal heart and quantification of blood flow in the surrounding vessels is very challenging because the heart is small and the fetus is free to move in the womb. Here, the authors demonstrate motion-corrected 4D flow MRI of the whole fetal heart and major vessels.

The three-dimensional structures of transparent objects, such as living cells, are captured by an imaging technique that uses white-light illumination and diffraction tomography to collect a stack of phase-based images.

A hybrid extracellular matrix–hydrogel with tunable mechanical stiffness and biochemical composition of young or aged cardiac tissue is used to identify the specific contributions of extracellular matrix ligands and mechanics for fibroblast aging.

Wedemeyer et al. find that age-associated waning of T-cell responses to infection and tolerance to self are regulated by a dynamic paracrine FGF21 signaling axis modulating mTORC1 and mTORC2 activity in thymic epithelial cells in mice.

The influence of magnetic fields on the current-driven motion of domain walls in nanowires with perpendicular anisotropy shows that two spin–orbit-derived mechanisms are responsible for their motion.

Anode-free batteries contain no active material at the negative electrode when manufactured, and this can enable them to have high energy density. This Perspective presents a critical overview of the mechanisms governing the behaviour of anode-free solid-state batteries and provides guidance to improve this type of battery.

Iterative expansion microscopy enables the use of confocal microscopes to uncover nanostructures in expanded yet otherwise intact tissues at a resolution of about 20 nm, as shown with the imaging of periodic amyloid nanoclusters in brain tissue.

Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-dependent membrane fusion activity.

Mapping the nature of multiprotein nanostructures in cellular contexts remains challenging. Here, Kang and Schroeder et al. report multiplexed expansion revealing, a technique which expands proteins away from each other, for nanoscale localisation and antibody visualisation of >20 proteins in the same specimen.

Inflammatory monocytes in the brain meninges promote stress-induced fear behaviour, and the pathways involved can be modulated using psychedelic compounds.

This study reveals near-atomic interfacial details of an Alzheimer’s Positron Emission Tomography (PET) molecule MK-6240 with its target disease marker, tau amyloid, showing MK-6240 mostly interacts with itself, like a pancake stack, which stabilizes an otherwise small interface with the amyloid.

Imaging heart development is challenging due to constant tissue movement and changing physical landmarks. Here the authors present an algorithm capable of maintaining phase-locked imaging throughout a 24 hour timespan, enabling long term timelapse imaging studies of zebrafish heart development, repair and regeneration.

Structural biology approaches are used to show how thyroxine is transported by monocarboxylate transporters (MCT)8 and 10, and MCT8 inhibition by silychristin. These findings shed light on how a MCT8 patient-derived mutation alters its function.

Mature parts of the shallow megathrust beneath Costa Rica are characterized by striking corrugations that may channel fluids, according to seismic images. Nascent sections of the subduction zone plate boundary appear only weakly corrugated.

Audio and visual stimulation at 40 Hz promote cerebrospinal and interstitial fluid flux in mouse brain and result in amyloid clearance via the glymphatic system in a mouse model of Alzheimer’s disease.

Neuromorphic hardware has typically focused on accelerating vector–matrix multiplication, but broader and more disruptive approaches will be required to reimagine AI hardware.

The authors develop a deep learning approach that enables an efficient search of the input space to find the best stimuli for modeled neurons. When tested, these stimuli are most effective at driving their matching cells in the brain.

Hybrid optical-electrical excitation drives magnetic tunnel junctions into a regime with giant thermovoltage output exhibiting a cubic dependence on current. This nonlinear response enables accurate neuromorphic computing, achieving 93.7% digit recognition and offering a pathway toward spintronic AI systems.

Human pluripotent stem cells are differentiated into CD32b⁺ putative liver sinusoidal progenitors and liver bud organoids using an inverted multilayered air–liquid interface culture.

Azole antifungals inhibit the ergosterol biosynthesis enzyme CYP51, but their effects on fungal viability and growth vary greatly among fungal species. Here, the authors provide evidence that the mode of action of azoles against Aspergillus fumigatus relies on accumulation of the CYP51 substrate eburicol, which exerts fungicidal effects by triggering cell-wall carbohydrate patch formation.

The authors use lineage tracing to map the fate of wild-type and Brca1^−/−;Trp53^−/− cells in the adult mouse mammary gland, identifying three layers of protection that limit the spread of mutant cells at the expense of allowing a minority of mutant cells to expand, which leads to field cancerization.

The need for space between lenses in optical systems results in a trade-off between potential for miniaturisation and achieved resolution. Here, the authors demonstrate a device that propagates light longer than its thickness, a spaceplate, and can therefore replace space in optical systems.

Photo-induced charge separation in organic semiconductors usually occurs at interfaces between electron donors and acceptors. Here, the authors show using photoluminescence measurements that charge separation is intrinsic and directional in organic crystalline nanowires made of stacked monomers.

The alignment of the bandgap of adjacent materials in a heterostructure largely determines the electronic properties of a device. Here, the authors measure the conduction and valance band offsets at the interface between two two-dimensional materials: molybdenum disulphide and tungsten diselenide.

How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA underpins the cell-size-scaling of mitochondria distribution and activity.

The shrinking dimensions, the increased structural complexity and the 3D stacking of silicon-based semiconductor devices are intensifying challenges in thermal dissipation. This Review explores thermal management materials, integration challenges and characterization methods, and proposes a road map for efficient heat dissipation solutions in 3D integration.