Nature Search

Naturally occurring antibodies devoid of light chains

C. Hamers-Casterman
T. Atarhouch
R. Hammers
Research03 Jun 1993
Nature

Volume: 363, P: 446-448
Native nucleosomes intrinsically encode genome organization principles

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Sangwoo Park
Raquel Merino-Urteaga
Taekjip Ha
ResearchOpen Access07 May 2025
Nature

Volume: 643, P: 572-581
Demethylation of methylguanidine by a stepwise dioxygenase and lyase reaction

The nitrogen-rich compound guanidine is a challenging nitrogen source for bacteria requiring specific degradation systems. Here, the authors characterize two enzymes that catalyze the stepwise demethylation of methylguanidine, enabling its use as nitrogen source.

Malte Sinn
Dietmar Funck
Jörg S. Hartig
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-9
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh
Igor Klyubin
Dennis J. Selkoe
Research04 Apr 2002
Nature

Volume: 416, P: 535-539
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

James P Cleary
Dominic M Walsh
Karen H Ashe
Research19 Dec 2004
Nature Neuroscience

Volume: 8, P: 79-84
NAT10-dependent N⁴‐acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation

N-acetyltransferase 10 (NAT10) is an N⁴‐acetylcytidine (ac⁴C) writer, which catalyzes RNA acetylation at cytidine N⁴ position on RNAs. Here, the authors show that NAT10 catalyzes ac⁴C addition to a long non-coding RNA encoded by the oncogenic DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV), triggering viral lytic reactivation from latency, which promotes NAT10 recruitment of IFI16 mRNA, resulting in inflammasome activation.

Qin Yan
Jing Zhou
Chun Lu
ResearchOpen Access10 Oct 2023
Nature Communications

Volume: 14, P: 1-12
PEX39 facilitates the peroxisomal import of PTS2-containing proteins

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins.

Walter W. Chen
Tony A. Rodrigues
Bettina Warscheid
ResearchOpen Access30 Jul 2025
Nature Cell Biology

Volume: 27, P: 1256-1271
Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria

Savio L. C. Woo
Alan S. Lidsky
Kathryn J. H. Robson
Research10 Nov 1983
Nature

Volume: 306, P: 151-155
Single-cell migration along and against confined haptotactic gradients

Haptotaxis was traditionally seen as migration up protein gradients. It is now shown that cells can also oscillate or migrate down the gradient.

Isabela Corina Fortunato
David B. Brückner
Xavier Trepat
Research26 Sept 2025
Nature Physics

Volume: 21, P: 1638-1647
Stellar structure via truncated M-fractional Lane–Emden solutions

Mohamed I. Nouh
Emad A.-B. Abdel-Salam
M. S. M. Bahgat
ResearchOpen Access11 Apr 2025
Scientific Reports

Volume: 15, P: 1-17
Strain-specific prion-protein conformation determined by metal ions

Jonathan D.F. Wadsworth
Andrew F. Hill
John Collinge
Research01 May 1999
Nature Cell Biology

Volume: 1, P: 55-59
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer

Pamela S. Ohashi
Tak W. Mak
Arthur Weiss
Research01 Aug 1985
Nature

Volume: 316, P: 606-609
TFIIH XPB mutants suggest a unified bacterial-like mechanism for promoter opening but not escape

Yin Chun Lin
Wai S Choi
Jay D Gralla
Research05 Jun 2005
Nature Structural & Molecular Biology

Volume: 12, P: 603-607
Somatic mutation and selection at population scale

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Andrew R. J. Lawson
Federico Abascal
Iñigo Martincorena
ResearchOpen Access08 Oct 2025
Nature

P: 1-10
Within-host genetic diversity of pneumococcal serotype 3 during one-year prolonged carriage in a healthy adult

In this work, authors tracked a pneumococcal serotype 3 strain persisting for a year in a healthy adult, revealing limited genetic change but stable multidrug resistance and features linked to vaccine escape.

Lusako L. Sibale
Stephanie W. Lo
Kondwani C. Jambo
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-12
A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferation

Yang et al. apply high-throughput structure probing approaches to characterize the secondary structure throughout the SARS-CoV-2 WT and VOC genomes, uncovering an ultra-long-range RNA-RNA interaction that directly binds ADAR1 to promote viral fitness.

Siwy Ling Yang
Louis DeFalco
Yue Wan
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci

Here, the authors identify mechanisms of glycosylation of intrinsically disordered regions present in streptococci membrane proteins, uncovering a functional role for glycosylation in Streptococcus mutans chaperone PrsA.

Mohammad M. Rahman
Svetlana Zamakhaeva
Natalia Korotkova
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

Melanie G. Lee
Paul Nurse
Research07 May 1987
Nature

Volume: 327, P: 31-35
Human-like driving behaviour emerges from a risk-based driver model

Most driver models were designed for specific scenario. Here, the authors developed a driver behaviour model that can be applied to multiple scenarios and show that human-like driving behaviour emerges when the Driver’s Risk Field is coupled to a controller that maintains the perceived risk below a threshold level.

Sarvesh Kolekar
Joost de Winter
David Abbink
ResearchOpen Access29 Sept 2020
Nature Communications

Volume: 11, P: 1-13
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function

Performing a CRISPR–Cas9 screen in aged mice, Sun and colleagues identify clusterin as a driver of myeloid-biased hematopoietic stem cell differentiation in aging, through regulation of mitochondrial function via a Mnf2-OXPHOS-p38-Cebpb regulatory axis.

Ninghe Sun
Chun-Hsin Lin
Yi Zhang
ResearchOpen Access30 Jun 2025
Nature Aging

Volume: 5, P: 1510-1527
Cooperative tandem binding of met repressor of Escherichia coli

Simon E. V. Phillips
Iain Manfield
Peter G. Stockley
Research26 Oct 1989
Nature

Volume: 341, P: 711-715
Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins

Using cryo-EM, the authors identified 42 MIPs, including outer junction protein CFAP77 and outer dense fibers, in native doublet microtubules of Tetrahymena thermophila. Knockout of CFAP77 reduced ciliary beat frequency and led to outer junction damage.

Shintaroh Kubo
Corbin S. Black
Khanh Huy Bui
ResearchOpen Access15 Apr 2023
Nature Communications

Volume: 14, P: 1-16
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

Michael K. Jones
Hongtao Wang
Andrzej S. Tarnawski
Research01 Dec 1999
Nature Medicine

Volume: 5, P: 1418-1423
A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4

BioID detection of Ebola virus–host interactions when computationally integrated with existing host protein-protein networks, revealed functional cell protein complexes supporting infection, including the RNA decapping complex.

Callie J. Donahue
Aditi S. Kesari
Robert A. Davey
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-18
Science in the FAST LANE

With the rules of the game changing before every season, Formula 1 engineers often have a matter of weeks to redesign their car before it is tested on the track. Karl Ziemelis and Charles Wenz join the race to the start line.

Karl Ziemelis
Charles Wenz
News13 Oct 2004
Nature

Volume: 431, P: 736-738
Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA

Bacterial deaminase toxins are weapons used in interbacterial antagonism and valuable tools in genome engineering. Here, the authors show how a single-stranded DNA-specific deaminase toxin, SsdA, deaminates cytosines in a sequence context-independent fashion and its utility in base editing.

Lulu Yin
Yanjun Chen
Hideki Aihara
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Life in the slow lane

Peter D. Moore
Books & Arts02 Mar 1995
Nature

Volume: 374, P: 26
Maternal stress triggers early-life eczema through fetal mast cell programming

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.

Nadine Serhan
Nasser S. Abdullah
Nicolas Gaudenzio
ResearchOpen Access27 Aug 2025
Nature

Volume: 646, P: 161-170
Antibodies in the breakdown lane

An engineered IgG induces degradation of endogenous IgG, providing a potential therapeutic approach to autoimmune disease.

Richard S Blumberg
Wayne I Lencer
News & Views01 Oct 2005
Nature Biotechnology

Volume: 23, P: 1232-1234
Analyzing the delays of target lane vehicles caused by vehicle lane-changing operation

Quantao Yang
Feng Lu
Jingsheng Wang
ResearchOpen Access11 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

Alessandra Eva
Keith C. Robbins
Stuart A. Aaronson
Research14 Jan 1982
Nature

Volume: 295, P: 116-119
Growth in the fat lane

Analysis of endothelial cells, which are involved in blood-vessel formation, unexpectedly reveals that proliferation in this cell type depends on fatty-acid oxidation to support DNA synthesis. See Article p.192

Robert A. Egnatchik
Ralph J. DeBerardinis
News & Views01 Apr 2015
Nature

Volume: 520, P: 165-166
Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE

Julia E. Parrish
Ben A. Oostra
David L. Nelson
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 229-235
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Esha Madan
António M. Palma
Rajan Gogna
Research09 Dec 2024
Nature Biotechnology

P: 1-15
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect

Andrew R Hallahan
Joel I Pritchard
James M Olson
Research20 Jul 2003
Nature Medicine

Volume: 9, P: 1033-1038
Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling

Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation.

Giada Vanni
Anna Citron
Stefano Piccolo
ResearchOpen Access01 Oct 2025
Nature Cell Biology

P: 1-14
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

C. Ruwende
S. C. Khoo
A. V. S. Hill
Research20 Jul 1995
Nature

Volume: 376, P: 246-249
Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin

Kara S Giddings
Ji Zhao
Rodney K Tweten
Research14 Nov 2004
Nature Structural & Molecular Biology

Volume: 11, P: 1173-1178
Brca1 required for T cell lineage development but not TCR loci rearrangement

Tak W. Mak
Anne Hakem
Razqallah Hakem
Research01 Jul 2000
Nature Immunology

Volume: 1, P: 77-82
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48

Ernst Jarosch
Christof Taxis
Thomas Sommer
Research28 Jan 2002
Nature Cell Biology

Volume: 4, P: 134-139
Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin

Deadenylation leads to mRNA decay, with PABPC1 protecting the poly(A) tail, while tristetraprolin and CCR4–NOT promote deadenylation. Here, the authors describe how these three proteins interact to regulate mRNA stability.

Filip Pekovic
Wi S. Lai
Eugene Valkov
ResearchOpen Access13 Aug 2025
Nature Communications

Volume: 16, P: 1-15
The mitotic STAG3–cohesin complex shapes male germline nucleome

Nagano et al. identify the third mitotic cohesin complex, STAG3–cohesin, which, with its unique biophysical properties, weakens insulation and rewires regulatory interactions of spermatogonial stem cells, shaping the male germline nucleome.

Masahiro Nagano
Bo Hu
Mitinori Saitou
Research25 Aug 2025
Nature Structural & Molecular Biology

P: 1-16
Microbiota-derived corisin accelerates kidney fibrosis by promoting cellular aging

Here, the authors identify the microbiota-derived corisin as a driver of diabetic kidney fibrosis via cellular aging and show that targeting corisin with a monoclonal antibody alleviates disease in mice, suggesting a potential therapeutic avenue.

Taro Yasuma
Hajime Fujimoto
Esteban C. Gabazza
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-29
Muscle-specific gene expression controlled by a regulatory element lacking a MyoDl-binding site

T. J. Baldwin
S. J. Burden
Research26 Oct 1989
Nature

Volume: 341, P: 716-720
The chick ovomucoid gene contains at least six intervening sequences

J. F. Catterall
J. P. Stein
B. W. O'Malley
Research01 Mar 1979
Nature

Volume: 278, P: 323-327
Differentiated parental DNA strands confer developmental asymmetry on daughter cells in fission yeast

Amar J. S. Klar
Research01 Apr 1987
Nature

Volume: 326, P: 466-470
Hinf family: a novel repeated DNA family of the human genome

Yasuaki Shimizu
Kouichi Yoshida
G. Chinnadurai
Research14 Apr 1983
Nature

Volume: 302, P: 587-590
Constitutional relaxation of insulin–like growth factor II gene imprinting associated with Wilms' tumour and gigantism

Osamu Ogawa
David M. Becroft
Anthony E. Reeve
Research01 Dec 1993
Nature Genetics

Volume: 5, P: 408-412
Instability of short tandem repeats (microsatellites) in human cancers

R. Wooster
A.-M. Cleton-Jansen
M.R. Stratton
Research01 Feb 1994
Nature Genetics

Volume: 6, P: 152-156
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus

Adrian C. Hayday
Stephen D. Gillies
Susumu Tonegawa
Research26 Jan 1984
Nature

Volume: 307, P: 334-340

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