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Showing 101–150 of 394 results

Advanced filters: Author: S Raynaud Clear advanced filters

Progressive arm and leg stiffness in a patient with chronic renal impairment

This Case Study illustrates the differential diagnosis and management of nephrogenic systemic fibrosis, a progressively debilitating fibrosing disorder. The authors describe the case of a 60-year-old woman with chronic renal disease who presented with progressive stiffness in her arms and legs following exposure to gadolinium-containing contrast media.

Kichul Shin
Scott R Granter
Samardeep Gupta
Reviews19 Aug 2008
Nature Clinical Practice Rheumatology

Volume: 4, P: 557-562
Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study

Cécile Trottet
Manuel Schürch
Fatma Alibaz-Oner
ResearchOpen Access01 Sept 2025
npj Digital Medicine

Volume: 8, P: 1-12
Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients

Loubna Chadli
Britt Sotthewes
Agnes Gardet
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Rapid Central Visual Field Progression Rate in Eyes with Open-Angle Glaucoma and Choroidal Microvasculature Dropout

Youn Hye Jo
Junki Kwon
Michael S. Kook
ResearchOpen Access12 Jun 2019
Scientific Reports

Volume: 9, P: 1-11
Sulphur isotope heterogeneity in the mantle from ion microprobe measurements of sulphide inclusions in diamonds

M. Chaussidon
F. Albarède
S. M. F. Sheppard
Research19 Nov 1987
Nature

Volume: 330, P: 242-244
Some characteristics of a rapidly rotating magnetized neutron star

A. Ray
S. M. Chitre
Research02 Jun 1983
Nature

Volume: 303, P: 409-410
Palaeoclimate sensitivity

Richard S. Lindzen
Research06 May 1993
Nature

Volume: 363, P: 25-26
Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients

Soo Ji Jeon
Hae-Young Lopilly Park
Chan Kee Park
ResearchOpen Access30 Oct 2018
Scientific Reports

Volume: 8, P: 1-12
Evidence for general instability of past climate from a 250-kyr ice-core record

W. Dansgaard
S. J. Johnsen
G. Bond
Research15 Jul 1993
Nature

Volume: 364, P: 218-220
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma

Stevan R. Knezevich
Deborah E. McFadden
Poul H.B. Sorensen
Research01 Feb 1998
Nature Genetics

Volume: 18, P: 184-187
Methane flux to the atmosphere from the Arabian Sea

N. J. P. Owens
C. S. Law
C. A. Llewellyn
Research28 Nov 1991
Nature

Volume: 354, P: 293-296
Oestradiol, sexual receptivity and cytosol progestin receptors in rat hypothalamus

Bruce Parsons
Thomas C. Rainbow
Bruce S. McEwen
Research02 Jul 1981
Nature

Volume: 292, P: 58-59
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity

René Michael Hoet
Edward H Cohen
Robert Charles Ladner
Research20 Feb 2005
Nature Biotechnology

Volume: 23, P: 344-348
BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations

Angela Peron
Felice D’Arco
Cristina Dias
ResearchOpen Access24 Oct 2024
European Journal of Human Genetics

Volume: 33, P: 312-324
Irregular glacial interstadials recorded in a new Greenland ice core

S. J. Johnsen
H. B. Clausen
J. P. steffensen
Research24 Sept 1992
Nature

Volume: 359, P: 311-313
Reflections on the EULAR recommendations for the treatment of systemic sclerosis

The treatment of systemic sclerosis (SSc) is complex as multiple organs are frequently involved and treatment is either for overall disease modification or is organ specific. EULAR has updated its treatment recommendations for SSc, reflecting data from some new trials. However, some features of SSc are not included.

Janet E. Pope
News & Views05 Jan 2017
Nature Reviews Rheumatology

Volume: 13, P: 134-136
Palaeotemperatures still exist in the Greenland ice sheet

D. Dahl-Jensen
S. J. Johnsen
Research20 Mar 1986
Nature

Volume: 320, P: 250-252
Pituitary hormone FSH directs the CREM functional switch during spermatogenesis

Nicholas S. Foulkes
Florence Schlotter
Paolo Sassone-Corsi
Research18 Mar 1993
Nature

Volume: 362, P: 264-267
Increased activity of northern vegetation inferred from atmospheric CO₂ measurements

C. D. Keeling
J. F. S. Chin
T. P. Whorf
Research11 Jul 1996
Nature

Volume: 382, P: 146-149
Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma

Marie-Pierre Simon
Florence Pedeutour
Jan P. Dumanski
Research01 Jan 1997
Nature Genetics

Volume: 15, P: 95-98
VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation

Acquired mutations of the gene UBA1 occurring in myeloid cells that result in the expression of impaired isoforms of the enzyme E1 have been described in patients with a severe adult onset auto-inflammatory syndrome called VEXAS. Here the authors profile patients with UBA1 mutations presenting with or without VEXAS disease and show VEXAS disease is characterized by inflammasome activation and monocyte dysregulation.

Olivier Kosmider
Céline Possémé
Benjamin Terrier
ResearchOpen Access30 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Antifibrotic effect of apremilast in systemic sclerosis dermal fibroblasts and bleomycin-induced mouse model

Tomoaki Higuchi
Kae Takagi
Yasushi Kawaguchi
ResearchOpen Access08 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Access to opioid analgesics and pain relief for patients with cancer

Patients with cancer frequently experience pain, which is considered to be the most-common and feared symptom of the disease. In most patients, this pain can be successfully relieved with judicious use of opioids. Unfortunately, there are a number of barriers to patients receiving adequate pain relief, which are outlined in this Review. Guidelines and strategies to improve pain relief for patients with cancer are also outlined.

Shalini Dalal
Eduardo Bruera
Reviews15 Jan 2013
Nature Reviews Clinical Oncology

Volume: 10, P: 108-116
Meiotic arrest and aneuploidy in MLH3-deficient mice

Steven M. Lipkin
Peter B. Moens
Paula E. Cohen
Research01 Jul 2002
Nature Genetics

Volume: 31, P: 385-390
Clarifying the effect of biodiversity on productivity in natural ecosystems with longitudinal data and methods for causal inference

Isolating the relationships between biodiversity and ecosystem functioning in natural ecosystems is challenging. Here, the authors apply a causal inference approach to observational data from grasslands and find a negative effect of biodiversity on productivity driven by non-native and rare species.

Laura E. Dee
Paul J. Ferraro
Michel Loreau
ResearchOpen Access05 May 2023
Nature Communications

Volume: 14, P: 1-12
A Phase I clinical and pharmacological study of cis-diamminedichloro(2-methylpyridine) platinum II (AMD473)

P Beale
I Judson
L Etterley
ResearchOpen Access01 Apr 2003
British Journal of Cancer

Volume: 88, P: 1128-1134
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance

A translational study demonstrates the role of myeloid inflammatory cells in driving disease progression and treatment resistance in prostate cancer and shows that these cells can be targeted therapeutically.

Christina Guo
Adam Sharp
Johann S. de Bono
ResearchOpen Access16 Oct 2023
Nature

Volume: 623, P: 1053-1061
C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

Anna Richards
Arn M J M van den Maagdenberg
John P Atkinson
Research29 Jul 2007
Nature Genetics

Volume: 39, P: 1068-1070
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.

Wei-Yu Lin
Sarah E. Fordham
James M. Allan
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Vascular complications of selected cancer therapies

Vascular complications following cancer treatment are relatively common, particularly in patients with advanced stages of cancer. In this Review, Dr Daher and Dr Yeh describe the vascular complications of treatment with 5-fluorouracil, bevacizumab, and several new tyrosine kinase inhibitors, with special emphasis on thrombotic complications and hypertension.

Iyad N Daher
Edward TH Yeh
Reviews14 Oct 2008
Nature Clinical Practice Cardiovascular Medicine

Volume: 5, P: 797-805
Sjögren syndrome

Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands, resulting in the development of sicca symptoms and systemic disease. In this Primer, the mechanisms as well as the diagnosis and management of SjS are described.

Pilar Brito-Zerón
Chiara Baldini
Manuel Ramos-Casals
Reviews07 Jul 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-20
Circulating cytokine levels in systemic sclerosis related interstitial lung disease and idiopathic pulmonary fibrosis

Boyang Zheng
Kevin J. Keen
James V. Dunne
ResearchOpen Access24 Apr 2023
Scientific Reports

Volume: 13, P: 1-7
Targeted therapy in patients with PIK3CA-related overgrowth syndrome

A PI3KCA inhibitor reverses symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA, and produces improvements in patients with PROS/CLOVES syndrome.

Quitterie Venot
Thomas Blanc
Guillaume Canaud
Research13 Jun 2018
Nature

Volume: 558, P: 540-546
Intra-arterial chemotherapy in locally advanced or recurrent carcinomas of the penis and anal canal: an active treatment modality with curative potential

A D Roth
C R Berney
P Alberto
ResearchOpen Access05 Dec 2000
British Journal of Cancer

Volume: 83, P: 1637-1642
Large changes in Pluto's atmosphere as revealed by recent stellar occultations

B. Sicardy
T. Widemann
H. Levato
Research10 Jul 2003
Nature

Volume: 424, P: 168-170
Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis

Dermatomyositis is a connective tissue disease within the group of idiopathic inflammatory myopathies. Although juvenile and adult dermatomyositis share some disease features, they differ in several key aspects. In this Review, Robinson and Reed discuss the unique characteristics that differ between juvenile and adult disease, including clinical features, pathogenesis and treatment.

Angela B. Robinson
Ann M. Reed
Reviews27 Sept 2011
Nature Reviews Rheumatology

Volume: 7, P: 664-675
Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers

E Rampazzo
R Bertorelle
A De Rossi
ResearchOpen Access13 Apr 2010
British Journal of Cancer

Volume: 102, P: 1300-1305
Exploring the association between systemic lupus erythematosus and osteonecrosis by Mendelian randomization analysis

Baochuang Qi
Jinglin Zhao
Yongqing Xu
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-15
Decrease in pulmonary function during bleomycin-containing combination chemotherapy for testicular cancer: not only a bleomycin effect

S Sleijfer
TW van der Mark
NH Mulder
Research01 Jan 1995
British Journal of Cancer

Volume: 71, P: 120-123
Nonmyeloablative allogeneic bone marrow transplantation for treatment of childhood overlap syndrome and small vessel vasculitis

O Y Jones
R A Good
R A Cahill
Research29 Mar 2004
Bone Marrow Transplantation

Volume: 33, P: 1061-1063
Label-free photoacoustic imaging of human palmar vessels: a structural morphological analysis

Y. Matsumoto
Y. Asao
M. Toi
ResearchOpen Access15 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern

A H Sawalha
B Namjou
J Harley
Research06 Sept 2002
Genes & Immunity

Volume: 3, P: S31-S34
Enlargement of microvascular dropout toward the disc-fovea axis indicates new central visual field defect in glaucoma

Eun Jung Lee
Do Young Park
Jong Chul Han
ResearchOpen Access01 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
Parental mosaicism of JAG1 mutations in families with Alagille syndrome

Joannis Giannakudis
Albrecht Röpke
Ingo Hansmann
Research11 Apr 2001
European Journal of Human Genetics

Volume: 9, P: 209-216
TH17 cells expressing CD146 are significantly increased in patients with Systemic sclerosis

Amira Gabsi
Xavier Heim
Raja Marrakchi
ResearchOpen Access27 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies

In this Review, Weber and Sullivan discuss the different types of immune-related adverse events associated with checkpoint inhibitors and how their treatment may shed light on their mechanisms and possible strategies and targets for prophylactic and therapeutic interventions to mitigate them.

Ryan J. Sullivan
Jeffrey S. Weber
Reviews27 Jul 2021
Nature Reviews Drug Discovery

Volume: 21, P: 495-508
Targeting protein kinases in central nervous system disorders

Although protein kinases are proving to be valuable therapeutic targets for various peripheral-tissue disorders, the development of kinase-targeted therapies for central nervous system (CNS) diseases remains a challenge. Here, Chico and colleagues discuss the issues associated with CNS drug discovery, present trends in small-molecule properties associated with blood–brain barrier penetrance and review emerging CNS protein kinase targets and compounds in development.

Laura K. Chico
Linda J. Van Eldik
D. Martin Watterson
Reviews01 Nov 2009
Nature Reviews Drug Discovery

Volume: 8, P: 892-909
Therapy Insight: the recognition and treatment of retinal manifestations of systemic vasculitis

A variety of retinal signs can occur in patients who have systemic vasculitides. Although retinal signs are usually treated by treatment of the systemic disease, specific therapy is indicated occasionally to preserve vision. This Review describes the pathogenesis, clinical features and treatment of retinal manifestations of systemic vasculitides.

Petros Aristodemou
Miles Stanford
Reviews01 Aug 2006
Nature Clinical Practice Rheumatology

Volume: 2, P: 443-451
Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining

Chul Hwan Bang
Jae Woong Yoon
Ji Hyun Lee
ResearchOpen Access14 Dec 2018
Scientific Reports

Volume: 8, P: 1-7
Risk factors for hypertension in primary Sjögren’s syndrome patients: a nomogram was constructed

Xueping Xu
Yong Shi
Han Wang
Research24 Sept 2021
Journal of Human Hypertension

Volume: 36, P: 996-1002

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