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Showing 1–50 of 207 results
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  • The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

    • Y. Liu
    • H. Sun
    • X.-X. Zuo
    Research
    Nature Astronomy
    Volume: 9, P: 564-576
  • A short-duration gamma-ray burst was detected along with a double neutron start merger gravitational wave by LIGO-Virgo on August 17th 2017. Here, the authors show that the fluence and spectral peak energy of this event fall into the lower portion of the distribution of known short-duration gamma-ray bursts.

    • B.-B. Zhang
    • B. Zhang
    • E.-W. Liang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-6
  • Sustainable synthesis of valuable organic compounds like lactams relies on efficient catalysts. Here, the authors report a bimetallic silver–rhenium catalyst that selectively converts cyclic imides to lactams with high efficiency, with close silver–rhenium contact being key to its performance.

    • Carles Lluna-Galán
    • Juan Camilo Arango-Daza
    • Jose R. Cabrero-Antonino
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25
  • The glycosyltransferase C1GalT1 directs a key step in protein O-glycosylation important for the expression of the cancer-associated Tn and T antigens. Here, the authors provide molecular insights into the function of C1GalT1 by solving the crystal structure of the Drosophila enzyme-substrate complex.

    • Andrés Manuel González-Ramírez
    • Ana Sofia Grosso
    • Ramon Hurtado-Guerrero
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15
  • Here, the authors investigate the proteome trajectory of human iPSCs differentiating into hepatic stellate cells (diHSCs) and identify RORA as a key transcription factor that governs metabolic reprogramming essential for diHSCs’ commitment, identity, and quiescent phenotype.

    • Raquel A. Martínez García de la Torre
    • Julia Vallverdú
    • Pau Sancho-Bru
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • The development of practical photonic quantum technologies will be aided by the spatial control of entangled photons. Lenget al. achieve on-chip spatial control of entangled photons by using domain engineering, rather than by using external optical elements.

    • H.Y. Leng
    • X.Q. Yu
    • S.N. Zhu
    Research
    Nature Communications
    Volume: 2, P: 1-5
  • Kdm1a is a histone demethylase implicated in intellectual disability. Here, the authors show that removing Kdm1a in neurons of the adult mouse forebrain disrupts silencing of nonneuronal genes and chromatin organization, emphasizing its role in preserving neuronal genome integrity.

    • Beatriz del Blanco
    • Sergio Niñerola
    • Ángel Barco
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Fossils of Cretaceous birds with feathers are rare and known mostly from China. Here, the authors show an enantiornithine bird from the Lower Cretaceous of Brazil with a fully articulated skeleton and rachis-dominated tail feathers, which has implications for our understanding of feather evolution.

    • Ismar de Souza Carvalho
    • Fernando E. Novas
    • José A. Andrade
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-5
  • The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

    • Ashley Budu-Aggrey
    • Anna Kilanowski
    • Lavinia Paternoster
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18
  • The authors describe BoltzNet, a neural network that learns the energy of transcription factor (TF)-DNA binding from genomic data and can be used to design new binding sites. They report the in vivo mapping and BoltzNet modeling of 139 E. coli TFs.

    • Patrick Lally
    • Laura Gómez-Romero
    • James E. Galagan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi2Te4, and has implications for quantum chromodynamics, cosmology and string theory.

    • Jian-Xiang Qiu
    • Barun Ghosh
    • Su-Yang Xu
    Research
    Nature
    Volume: 641, P: 62-69
  • Topological boundary modes within charge-ordered states have not yet been observed experimentally. Now an in-gap boundary mode, stemming solely from the charge order, is visualized in the topological material Ta2Se8I.

    • Maksim Litskevich
    • Md Shafayat Hossain
    • M. Zahid Hasan
    Research
    Nature Physics
    Volume: 20, P: 1253-1261
  • Malaria on Bioko Island has been reduced substantially but many acquire malaria while traveling. Here, the authors use survey data, geostatistical and mathematical modeling to investigate malaria prevalence and mobility patterns and find that in some parts of the island a significant fraction of prevalence is attributable to malaria acquired while traveling.

    • Carlos A. Guerra
    • Su Yun Kang
    • David L. Smith
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10
  • O-alkylation of carboxylates by alkyl halides has only been observed transiently in enzymatic processes. Here, the authors show a carboxylate alkylating enzyme, BrtB, that catalyzes C-O bond formation between free fatty acids and secondary alkyl chlorides.

    • João P. A. Reis
    • Sandra A. C. Figueiredo
    • Pedro N. Leão
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9
  • Forest carbon source and sink processes may have contrasting climatic sensitivities. This analysis on 177 coniferous forest sites shows that carbon fluxes and wood formation are coupled but not fully synchronous at intra-annual scales, with peaks in cambial activity preceding those in photosynthesis and respiration.

    • Roberto Silvestro
    • Maurizio Mencuccini
    • Sergio Rossi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • An integrative genomic analysis of several hundred endometrial carcinomas shows that a minority of tumour samples carry copy number alterations or TP53 mutations and many contain key cancer-related gene mutations, such as those involved in canonical pathways and chromatin remodelling; a reclassification of endometrial tumours into four distinct types is proposed, which may have an effect on patient treatment regimes.

    • Douglas A. Levine
    • Gad Getz
    • Douglas A. Levine
    ResearchOpen Access
    Nature
    Volume: 497, P: 67-73
  • Comprehensive analyses of 178 lung squamous cell carcinomas by The Cancer Genome Atlas project show that the tumour type is characterized by complex genomic alterations, with statistically recurrent mutations in 11 genes, including TP53 in nearly all samples; a potential therapeutic target is identified in most of the samples studied.

    • Peter S. Hammerman
    • Michael S. Lawrence
    • Matthew Meyerson
    ResearchOpen Access
    Nature
    Volume: 489, P: 519-525
  • Single nucleotide polymorphisms—SNPs—have been identified for prostate cancer but whether these SNPs alter the expression of genes is largely unknown. In this study, the authors search for genes located within 2 Mb of the SNPs and identify SNPs that influence gene expression, so called expression quantitative trait loci.

    • S. N. Thibodeau
    • A. J. French
    • D J. Schaid
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10
  • Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

    • Xia Jiang
    • Hilary K. Finucane
    • Sara Lindström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-23
  • A very uncommon detached binary system with a 20.5-min orbital period has been discovered to harbour a carbon–oxygen white dwarf star and a low-mass subdwarf B star with a seven-Earth radius that traces the theoretical limit of binary evolution predicted 20 years ago.

    • Jie Lin
    • Chengyuan Wu
    • Wenxiong Li
    Research
    Nature Astronomy
    Volume: 8, P: 491-503
  • This paper reports integrative molecular analyses of urothelial bladder carcinoma at the DNA, RNA, and protein levels performed as part of The Cancer Genome Atlas project; recurrent mutations were found in 32 genes, including those involved in cell-cycle regulation, chromatin regulation and kinase signalling pathways; chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far.

    • John N. Weinstein
    • Rehan Akbani
    • Greg Eley
    ResearchOpen Access
    Nature
    Volume: 507, P: 315-322
  • The Cancer Genome Atlas consortium reports on their genome-wide characterization of somatic alterations in colorectal cancer; in addition to revealing a remarkably consistent pattern of genomic alteration, with 24 genes being significantly mutated, the study identifies new targets for therapeutic intervention and suggests an important role for MYC-directed transcriptional activation and repression.

    • Donna M. Muzny
    • Matthew N. Bainbridge
    • Elizabeth Thomson.
    ResearchOpen Access
    Nature
    Volume: 487, P: 330-337
  • Cancer genetics has benefited from the advent of next generation sequencing, yet a comparison of sequencing and analysis techniques is lacking. Here, the authors sequence a normal-tumour pair and perform data analysis at multiple institutes and highlight some of the pitfalls associated with the different methods.

    • Tyler S. Alioto
    • Ivo Buchhalter
    • Ivo G. Gut
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13
  • The Cancer Genome Atlas presents an integrative genome-wide analysis of genetic alterations in 279 head and neck squamous cell carcinomas (HNSCCs), which are classified by human papillomavirus (HPV) status; alterations in EGFR, FGFR, PIK3CA and cyclin-dependent kinases are shown to represent candidate targets for therapeutic intervention in most HNSCCs.

    • Michael S. Lawrence
    • Carrie Sougnez
    • Wendell G. Yarbrough
    ResearchOpen Access
    Nature
    Volume: 517, P: 576-582
  • Pluripotent stem cell colonies are encircled by large cornerstone focal adhesions (FAs). Here, using super-resolution imaging, the authors describe features in the nanoscale makeup of these stable FAs such as inverted vinculin, lateral talin segregation and distinct kank protein distributions.

    • Aki Stubb
    • Camilo Guzmán
    • Johanna Ivaska
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15
  • Last year the first map of single nucleotide changes was published; now an international consortium has mapped even larger areas of differences, called copy number variants. These variants are at least 1,000-base-pair differences between individual people, and have been linked to both benign and disease-causing changes in the human genome.

    • Richard Redon
    • Shumpei Ishikawa
    • Matthew E. Hurles
    Research
    Nature
    Volume: 444, P: 444-454
  • This study analyses radio observations of the jet in galaxy M87, from which the existence of a spinning black hole that induces Lense–Thirring precession of a misaligned accretion disk is inferred.

    • Yuzhu Cui
    • Kazuhiro Hada
    • Weiye Zhong
    Research
    Nature
    Volume: 621, P: 711-715
  • The Cancer Genome Atlas Research Network reports an integrative analysis of more than 400 samples of clear cell renal cell carcinoma based on genomic, DNA methylation, RNA and proteomic characterisation; frequent mutations were identified in the PI(3)K/AKT pathway, suggesting this pathway might be a potential therapeutic target, among the findings is also a demonstration of metabolic remodelling which correlates with tumour stage and severity.

    • Chad J. Creighton
    • Margaret Morgan
    • Heidi J. Sofia.
    ResearchOpen Access
    Nature
    Volume: 499, P: 43-49
  • The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-14
  • In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.

    • Xuemei Ji
    • Semanti Mukherjee
    • Christopher I. Amos
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • In all experimentally observed Weyl semimetals so far, the Weyl points always appear in pairs in the momentum space. Here, the authors report one unpaired Weyl point without surface Fermi arc emerging at the center of the Brillouin zone, which is surrounded by charged Weyl nodal walls in PtGa.

    • J.-Z. Ma
    • Q.-S. Wu
    • M. Shi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8
    • Rong Wang
    • John A. Dearing
    • Marten Scheffer
    Research
    Nature
    Volume: 498, P: E12-E13
  • In modelling of epidemic spreading processes, a reproduction number is crucial to shape the model dynamics. The authors analyze how evolving pathogens may impact the reproduction number and macroscopic dynamics of spreading processes.

    • Xiyun Zhang
    • Zhongyuan Ruan
    • Baruch Barzel
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • The Cancer Genome Atlas reports on molecular evaluation of 295 primary gastric adenocarcinomas and proposes a new classification of gastric cancers into 4 subtypes, which should help with clinical assessment and trials of targeted therapies.

    • Adam J. Bass
    • Vesteinn Thorsson
    • Jia Liu
    ResearchOpen Access
    Nature
    Volume: 513, P: 202-209
  • An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

    • Eric A. Collisson
    • Joshua D. Campbell
    • Ming-Sound Tsao
    ResearchOpen Access
    Nature
    Volume: 511, P: 543-550
  • Microscopic transition mechanisms impact many biophysical systems. In this work, the authors explore transition path times between thermodynamic states experimentally, and show symmetry breaking in the transition times under an external force that drives the system out of equilibrium.

    • J. Gladrow
    • M. Ribezzi-Crivellari
    • U. F. Keyser
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9