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Showing 51–100 of 118 results

Advanced filters: Author: S. WEINREB Clear advanced filters

The primary treatment trial: Changes in the visual field analysis by computer-assisted perimetry

R A Hitchings
C S Migdal
F Fitzke
Research01 Jan 1994
Eye

Volume: 8, P: 117-120
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis

Using single-cell lineage tracing, the authors identify TCF15 as a novel regulator of haematopoietic stem cell quiescence and self-renewal.

Alejo E. Rodriguez-Fraticelli
Caleb Weinreb
Fernando D. Camargo
Research15 Jul 2020
Nature

Volume: 583, P: 585-589
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Decarboxylative alkenylation

Starting with alkyl carboxylic acids, a simple olefin synthesis using any substitution pattern or geometry, based on amide-bond synthesis with nickel- or iron-based catalysis, is described.

Jacob T. Edwards
Rohan R. Merchant
Phil S. Baran
Research19 Apr 2017
Nature

Volume: 545, P: 213-218
Reply: Antibody levels against BK virus and prostate, kidney and bladder cancers in the EPIC-Oxford cohort

R Newton
P Coursaget
I S D Roberts
CorrespondenceOpen Access13 Jun 2006
British Journal of Cancer

Volume: 94, P: 1949-1950
Detecting hierarchical genome folding with network modularity

3DNetMod identifies nested topologically associating domains (TADs) and subTADs from Hi-C data.

Heidi K Norton
Daniel J Emerson
Jennifer E Phillips-Cremins
Research15 Jan 2018
Nature Methods

Volume: 15, P: 119-122
Seasonal variations in the onset of childhood leukaemia and lymphoma

RMC Westerbeek
V Blair
JM Birch
Research01 Jul 1998
British Journal of Cancer

Volume: 78, P: 119-124
South Asian ethnicity and material deprivation increase the risk of Epstein-Barr virus infection in childhood Hodgkin's disease

K J Flavell
J P Biddulph
P G Murray
ResearchOpen Access31 Jul 2001
British Journal of Cancer

Volume: 85, P: 350-356
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is the most common form of glaucoma and is characterized by deformation of the optic nerve head and vision loss. This Primer by Weinreb et al. discusses the risk factors, pathophysiology, diagnosis and management of POAG.

Robert N. Weinreb
Christopher K. S. Leung
Keith R. Martin
Reviews22 Sept 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-19
A validated disease severity scoring system for adults with type 1 Gaucher disease

Neal J Weinreb
Maria D Cappellini
Ari Zimran
Research18 Dec 2009
Genetics in Medicine

Volume: 12, P: 44-51
Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes

Ana Paula Martins Sebastiao
Bin Xu
Nora Katabi
Research06 Sept 2019
Modern Pathology

Volume: 33, P: 65-73
A fast radio burst associated with a Galactic magnetar

Observations of the fast radio burst FRB 200428 coinciding with X-rays from the Galactic magnetar SGR 1935+2154 indicate that active magnetars can produce fast radio bursts at extragalactic distances.

C. D. Bochenek
V. Ravi
D. L. McKenna
Research04 Nov 2020
Nature

Volume: 587, P: 59-62
Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma

H E Colley
V Hearnden
C Murdoch
ResearchOpen Access11 Oct 2011
British Journal of Cancer

Volume: 105, P: 1582-1592
Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis

The fetal murine foregut develops into visceral organs via interactions between the mesoderm and endoderm, but how is unclear. Here, the authors use single cell RNAseq to show a diversity in organ specific splanchnic mesoderm cell-types, infer a signalling network governing organogenesis and use this to differentiate human pluripotent stem cells.

Lu Han
Praneet Chaturvedi
Aaron M. Zorn
ResearchOpen Access27 Aug 2020
Nature Communications

Volume: 11, P: 1-16
Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma

A Reiman
J E Powell
P G Murray
ResearchOpen Access30 Sept 2003
British Journal of Cancer

Volume: 89, P: 1200-1201
Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4

Chandru Gajendran
Shoichi Fukui
Dhanalakshmi Sivanandhan
ResearchOpen Access23 Feb 2023
Scientific Reports

Volume: 13, P: 1-14
The dynamics of hematopoiesis over the human lifespan

This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.

Hojun Li
Parker Côté
R. Grant Rowe
Research05 Dec 2024
Nature Methods

Volume: 22, P: 422-434
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.

Adriana I. Iglesias
Aniket Mishra
Stuart MacGregor
ResearchOpen Access14 May 2018
Nature Communications

Volume: 9, P: 1-11
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Jorge Reis-Filho and colleagues identify recurrent mutations in PRKD1 in 73% of polymorphous low-grade adenocarcinoma, a malignant tumor of the minor salivary glands. The mutations cause activation of the PRKD1 serine-threonine kinase.

Ilan Weinreb
Salvatore Piscuoglio
Jorge S Reis-Filho
Research21 Sept 2014
Nature Genetics

Volume: 46, P: 1166-1169
The corneal endothelium

S J Tuft
D J Coster
Research01 May 1990
Eye

Volume: 4, P: 389-424
Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals

Kathie Y. Sun
Xiaodong Bai
Suganthi Balasubramanian
Amendments and CorrectionsOpen Access08 Jan 2025
Nature

Volume: 637, P: E26
Design of selective nuclear receptor modulators: RAR and RXR as a case study

Retinoic acid receptors (RARs) are important drug targets for cancer therapy and prevention, and the potential of rexinoids for the treatment of metabolic diseases is increasingly being recognized. This article reviews recent structural data for RARs and retinoid X receptors (RXRs), discusses strategies in the design of selective RXR and RAR modulators, and consider lessons that can be learned for the design of selective nuclear-receptor modulators in general.

Angel R. de Lera
William Bourguet
Hinrich Gronemeyer
Reviews01 Oct 2007
Nature Reviews Drug Discovery

Volume: 6, P: 811-820
Synthesis and anti-obesity effects in vivo of Crotadihydrofuran C as a novel PPARγ antagonist from Crotalaria albida

Qin-Hu Sun
Yu Zhang
Gui-Xin Chou
ResearchOpen Access24 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Polyoma virus infection and urothelial carcinoma of the bladder following renal transplantation

I S D Roberts
D Besarani
R Newton
ResearchOpen Access28 Oct 2008
British Journal of Cancer

Volume: 99, P: 1383-1386
Correlation between the orbital and intraocular portions of the optic nerve in glaucomatous and ocular hypertensive eyes

S Beatty
P A Good
E C O'Neill
Research01 Jul 1998
Eye

Volume: 12, P: 707-713
A fast radio burst localized to a massive galaxy

Use of a specially built radio interferometer shows that a non-repeating fast radio burst is localized to a few-arcsecond region containing a single massive galaxy, and is perhaps derived from an old stellar population.

V. Ravi
M. Catha
D. P. Woody
Research02 Jul 2019
Nature

Volume: 572, P: 352-354
Clonal analysis of lineage fate in native haematopoiesis

Transposon tagging to clonally trace progenitors and stem cells provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

Alejo E. Rodriguez-Fraticelli
Samuel L. Wolock
Fernando D. Camargo
Research03 Jan 2018
Nature

Volume: 553, P: 212-216
Strong coupling of a single photon to a superconducting qubit using circuit quantum electrodynamics

A. Wallraff
D. I. Schuster
R. J. Schoelkopf
Research09 Sept 2004
Nature

Volume: 431, P: 162-167
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Janey Wiggs, Jonathan Haines and colleagues identify three new susceptibility loci for primary open-angle glaucoma. The association signals map near genes implicated in ocular development (FOXC1), neurodegeneration (ATXN2) and mitochondrial function (TXNRD2).

Jessica N Cooke Bailey
Stephanie J Loomis
Janey L Wiggs
Research11 Jan 2016
Nature Genetics

Volume: 48, P: 189-194
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas

Nada Jabado, Jacek Majewski and colleagues identify mutations in multiple histone H3 genes causing recurrent p.Lys36Met alterations in head and neck squamous cell carcinomas. They show that tumors with these p.Lys36Met alterations correspond to a specific DNA methylation cluster along with tumors harboring previously described mutations in NSD1.

Simon Papillon-Cavanagh
Chao Lu
Nada Jabado
Research09 Jan 2017
Nature Genetics

Volume: 49, P: 180-185
Evaluation of baseline structural factors for predicting glaucomatous visual-field progression using optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy

M Sehi
N Bhardwaj
D S Greenfield
Research12 Oct 2012
Eye

Volume: 26, P: 1527-1535
Pupillary distortion and staphyloma following trans-scleral contact diode laser cyclophotocoagulation: a clinicopathological study of three patients

R M Bhola
S Prasad
M A Parsons
Research01 Jul 2001
Eye

Volume: 15, P: 453-457
[¹⁸F]FluorThanatrace PET imaging as a biomarker of response to PARP inhibitors in breast cancer

Gitto, Pantel et al. evaluate a PARP-targeted PET imaging ligand, [18 F]FlourThanatrace, as a biomarker of response to PARP inhibitors in patients with breast cancer. There is [18 F]FlourThanatrace uptake in the tumor before treatment, and a decline in uptake after PARP inhibitor therapy initiation, correlating with patient progression free survival.

Sarah B. Gitto
Austin R. Pantel
Elizabeth S. McDonald
ResearchOpen Access25 Mar 2025
Communications Medicine

Volume: 5, P: 1-8
Comparison of three methods of intraocular pressure measurement and their relation to central corneal thickness

F Carbonaro
T Andrew
C J Hammond
Research12 Feb 2010
Eye

Volume: 24, P: 1165-1170
Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice

Sally L. Baxter
William T. Keenan
Robert N. Weinreb
ResearchOpen Access04 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Individualization of long-term enzyme replacement therapy for Gaucher disease

Hans C Andersson
Joel Charrow
Neal J Weinreb
Reviews01 Feb 2005
Genetics in Medicine

Volume: 7, P: 105-110
Performance of Deep Learning Architectures and Transfer Learning for Detecting Glaucomatous Optic Neuropathy in Fundus Photographs

Mark Christopher
Akram Belghith
Linda M. Zangwill
ResearchOpen Access12 Nov 2018
Scientific Reports

Volume: 8, P: 1-13
Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human proteasome to allow selective targeting with inhibitors.

Hao Li
Anthony J. O’Donoghue
Matthew Bogyo
Research10 Feb 2016
Nature

Volume: 530, P: 233-236
Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming

Devansh Agarwal
Nicholas Dash
Karl J. Wahlin
ResearchOpen Access29 Sept 2023
npj Regenerative Medicine

Volume: 8, P: 1-18
Anterior chamber angle imaging with optical coherence tomography

C K-S Leung
R N Weinreb
Research14 Jan 2011
Eye

Volume: 25, P: 261-267
Neovascular glaucoma after bypass surgery in Takayasu's disease

D Milea
N Cassoux
E Kieffer
Correspondence01 Nov 1999
Eye

Volume: 13, P: 786-789
A hierarchical deep learning approach with transparency and interpretability based on small samples for glaucoma diagnosis

Yongli Xu
Man Hu
Ningli Wang
ResearchOpen Access11 Mar 2021
npj Digital Medicine

Volume: 4, P: 1-11
A multicenter open-label treatment protocol (HGT-GCB-058) of velaglucerase alfa enzyme replacement therapy in patients with Gaucher disease type 1: safety and tolerability

Gregory M. Pastores
Barry Rosenbloom
David Zahrieh
ResearchOpen Access21 Nov 2013
Genetics in Medicine

Volume: 16, P: 359-366
Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Adriana I. Iglesias
Aniket Mishra
Stuart MacGregor
Amendments and CorrectionsOpen Access08 Jan 2019
Nature Communications

Volume: 10, P: 1-3
Effects of scan circle displacement in optical coherence tomography retinal nerve fibre layer thickness measurement: a RNFL modelling study

C Y L Cheung
C K F Yiu
C K S Leung
Research19 Sept 2008
Eye

Volume: 23, P: 1436-1441
Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract

Ying-Ju Kuo
James S. Lewis Jr.
Jen-Fan Hang
Research14 Jun 2022
Modern Pathology

Volume: 35, P: 1587-1595
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

J T Korpi
V Kervinen
T Salo
ResearchOpen Access05 Feb 2008
British Journal of Cancer

Volume: 98, P: 766-775
DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology

Ying-Ju Kuo
James S. Lewis Jr.
Jen-Fan Hang
Research09 Jun 2021
Modern Pathology

Volume: 34, P: 1820-1830
Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Ivano Riva
Lorenzo Legramandi
A. Bagnis
ResearchOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1-11

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