Using an exploratory phenome-wide association study of polygenic risk scores (PRS) in children aged 9–13 from the Adolescent Brain Cognitive Development Study cohort, the authors identify neurodevelopmental and internalizing PRS associations with multiple phenotypes similar to the constituent GWAS indicators (for example, neurodevelopmental and internalizing traits) as well as cross-trait phenotypes (for example, screen time, cortical volume).
- Sarah E. Paul
- Sarah M. C. Colbert
- Nicole R. Karcher