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Complex-frequency waves compensate for optical losses, but their efficacy is limited in systems with extreme losses. Now, high-order virtual gain excitations have been shown to preserve loss compensation efficiency in plasmonic resonance systems.

Covalent organic frameworks are a potentially useful class of materials, although they are currently synthesized using relatively few reactions. Here, the authors show that the imidization reaction can be used to prepare a series of large pore polyimide frameworks with high surface area and thermal stability.

Yersinia pseudotuberculosis senses fungal tyrosol signalling through EnvZ–OmpR which triggers T6SS activation and antifungal effector release to reduce fungal competitors in the mouse gut.

EuCo₂Al₉ is identified as a metallic spin supersolid with high thermal conductivity, exhibiting coexisting spin orders, strong quantum fluctuations and a giant magnetocaloric effect enabling efficient sub-Kelvin refrigeration.

A strategy based on the design of a composite coating that enables slip-enhanced close-contact melting inside sealed phase-change thermal batteries to improve charging rates enables high-performance thermal energy storage over a wide range of temperatures.

This work introduces synthetic gain to electron-beam spectroscopy, greatly enhancing spectral resolution and revealing hidden features, enabling advances in nanoscale analysis and free electron-based quantum optics under challenging signal conditions.

Poly(vinylidene fluoride-co-trifluoroethylene)’s (PVDF-TrFE) piezoelectricity can be enhanced by annealing, however current annealing methods are slow. Here, the authors perform ultra-fast flash annealing of PVDF-TrFE to achieve a high piezoelectricity.

Li et al. report free-standing layered polymer–perovskite composite membranes that reconcile mechanical flexibility with electronic properties. They endure 30,000 bends at a 1.5 mm radius, enabling wearable radiation monitoring in complex conditions.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

The interplay of magnetism, various symmetries and correlations can lead to intriguing physics in the solid state. Here, the authors report signatures of a Hund nodal line in the antiferromagnet YMn₂Ge₂.

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the authors show that TIGIT limits the differentiation of inflammatory Th1 and Th17 cells via a metabolic-epigenetic mechanism, which involves the inhibition of CD28-mediated PI3K/AKT/mTOR costimulatory signaling.

Experimental observation of flux periodicity ϕ₀/2 for interference of the outermost edge mode of Fabry-Perot interferometers has been attributed to exotic electron pairing mechanisms. Here, the authors demonstrate that the interfering charges of a Fabry-Perot interferometer are single electrons

Measurements of anyons moving through a quantum point contact allow the extraction of their tunnelling exponent. This fully characterizes their topological order and confirms that they are well described by the Luttinger liquid theory.

Most genetic risk variants for brain disorders lie in non-coding regions and are difficult to interpret. Here, the authors develop BASIC, a method integrating bulk and single-cell eQTLs, to reveal cell-type-specific effects and improve gene discovery and disease colocalization.

The molecular phenotypic features of epithelial ovarian cancer (EOC) remain elusive. Here, the authors perform mass spectrometry-based proteomic profiling for 269 EOC patients and reveal molecularly distinct features and potential therapeutic targets among the histological subtypes of EOC.

In non-human primates, rAAVs are delivered through suprachoroidal injection at a high dose to achieve optimal efficacy. Here, the authors present a novel AAV capsid (AAVv128) that significantly improved the transduction efficiency in photoreceptor and retinal pigment epithelial cells across species.

Ligand-targeted nanocarriers are desirable for their potential to enhance precise drug delivery to targeted tissues, but their clinical translation faces challenges like protein corona formation. Here, Li et al. develop surface-galloylated liposomes that enable stable, non-covalent adsorption of antibodies while overcoming protein corona interference.

ACSS2 catalyzes the conversion of acetate to acetyl-CoA. Here, authors show that ACSS2 regulates iron metabolism and ferroptosis in alcoholic liver disease by modulating the histone acetylation of HAMP1/2.

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

We demonstrate a 3D generalized vector vortex array generation with full polarization, phase, OAM, and spatial control, by using joint optimization in different diffraction orders based on a single-layer metasurface.

Isotropic tissue magnification is integrated with matrix-assisted laser desorption/ionization mass spectrometry imaging to enable untargeted spatial proteomics at micrometre resolution and with high protein identification rates in multiple tissue types.

Radiosensitising agents can enhance radiotherapy and improve outcomes. Here, the authors report on the design of bioinspired Radiosensitising and biocatalytic nanoparticles to increase radiation tiggered cell death and immunogenic response to combat both primary and metastatic tumours.

The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response.

Ruthenium (Ru(II)) compounds are of interest as platinum drug replacements but have suffered from suboptimal therapeutic efficiency. Here, the authors design a Ru(II) metallacycle with NIR excitation and emission wavelengths and demonstrate application for deep tumour imaging and chemo-photo therapy.

The study shows that high-coordination-shell defects in Fe-N₅ single-atom catalysts enhance peroxymonosulfate activation, enabling rapid and selective degradation of pollutants and revealing how remote site modulation controls catalytic efficiency.

Prenatal bisphenol A exposure is associated with an increased risk of ASD in boys through a mechanism involving aromatase suppression. These resulting ASD-related behaviors and brain abnormalities may be reversed through postnatal intervention with 10HDA in mice.

Elucidating the nature of topological magnets is at quantum frontier. Here the authors report a topological charge-entropy relation in TbMn₆Sn₆ that goes beyond conventional electron behavior and points to a transport visualization of Chern gapped Dirac fermions.

Stacking perovskite LEDs in tandem structures to combine the luminance of individual units yielded efficiencies greater than the summed efficiencies of equivalent single-unit devices, suggested to result from photon recycling between individual light-emitting elements.

Radiofrequency switches based on micro-electromechanical systems or phase-change materials are large and require high voltages. Here, the authors demonstrate a nanoscale radiofrequency switch based on a memristive device with actuation voltages as low as 0.4 V and a typical cutoff frequency of 35 THz.

Controllable and low-cost holographic display devices are always desired. Here the authors demonstrate an approach of creating light projection device based on electrical control of digital metasurface device.

Integration of longitudinal single-cell analysis of relapsed and refractory multiple myeloma patients in a prospective clinical trial uncovers new pathways of drug resistance and identifies potential actionable targets.

Improving phosphorus (P) acquisition efficiency is important for sustainable agriculture. Here, the authors report a natural variation in an upstream open reading frame of a SEC12-like gene GmPHF1 is crucial for protein abundance and spatial distribution of GmPHF1, which contribute to P acquisition diversity in soybean.

Realizing metasurfaces with reconfigurability, high efficiency, and control over phase and amplitude is a challenge. Here, Li et al. introduce a reprogrammable hologram based on a 1-bit coding metasurface, where the state of each unit cell of the coding metasurface can be switched electrically.

N-glycosylation has a significant role in immunosuppressive tumor microenvironment (TME). Here, the authors design an injectable ROS-sensitive hydrogel scaffold co-delivering piezocatalyst BiFeO₃ and glucose/mannose analog 2-deoxy-d-glucose alleviating N-glycosylation inhibition and thereby effectively stimulating immune responses within TME.

The methyltransferase OsPRMT6b is found to act as an ABA responsive factor to finely turn down ABA signaling via methylation of ABA receptor, thus facilitating growth recovery as high-temperature stress subsides.

By characterizing the dynamics of epitranscriptomes and translatomes upon Magnaporthe oryzae infection, the authors uncover that ac4C enriched in the 3rd nt of codons improves translation of mRNA to enhance rice resistance against M. oryzae.

Photonic synthetic dimension (on TFLN chip) attracts broad interest. Here, authors achieve tunable couplings via MZI-linked resonators, and prove its versatility by realizing multiple models including tight-binding lattice, the Hall ladder and Creutz ladder along with their featured phenomena

By using femtosecond laser writing technique, the research group in Nanjing University has fabricated 3D nano-resolution nonlinear holograms in lithium niobate crystals, which is capable of processing optical information across the wavelength gaps.