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Showing 1–50 of 68 results

Advanced filters: Author: Siming Chen Clear advanced filters

Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

Zhongchen Liu
Ruizhen Liu
Guohong Zhuang
Research01 Jun 2009
Cellular & Molecular Immunology

Volume: 6, P: 167-174
Towards expert-level autonomous carotid ultrasonography with large-scale learning-based robotic system

Ultrasound examination significantly relies on manual operation, which has significant downsides. The authors present UltraBot, a carotid ultrasound robot capable of automated scanning, measurement, and plaque screening, and build an embodied foundation model using deep learning for intelligent, high-precision ultrasound.

Haojun Jiang
Andrew Zhao
Gao Huang
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-21
Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme

Heme units are immobilised in diverse heme enzymes for oxidation, and have been immobilised also in hydrogen-bonded organic frameworks. Here, the authors show the use of hydrogen-bonded organic framework to modulate the enzyme’s conformation and show different biofunction from the original.

Guosheng Chen
Linjing Tong
Gangfeng Ouyang
ResearchOpen Access16 Aug 2022
Nature Communications

Volume: 13, P: 1-10
RGD-FasL Induces Apoptosis in Hepatocellular Carcinoma

Zhongchen Liu
Juan Wang
Guohong Zhuang
Research01 Aug 2009
Cellular & Molecular Immunology

Volume: 6, P: 285-293
Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway

Tao Zhang
Hongzhi Lv
Yanbin Zhu
ResearchOpen Access24 Sept 2025
Bone Research

Volume: 13, P: 1-18
An aggregation-induced conformation locking strategy facilitates the activation of lipase biocatalyst

Lipase is one of the most important industrial biocatalysts with wide applications, but its catalytic efficiency is often hindered by a closed lid conformation. Here, the authors present an aggregation-induced conformation locking strategy that enables the facile synthesis of highly activated lipase hybrid biocatalysts.

Anlian Huang
Zhi-Wei Li
Gangfeng Ouyang
ResearchOpen Access19 May 2025
Nature Communications

Volume: 16, P: 1-13
Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor

Integration of nanomaterials and enzymes has potential in the development of robust biocatalysts, but preparation can still be technically challenging. Here, the authors report the preparation of a hydrogen-bonded organic framework biocatalyst and its use as an immunosensor.

Wei Huang
Haitao Yuan
Gangfeng Ouyang
ResearchOpen Access20 Jun 2023
Nature Communications

Volume: 14, P: 1-11
A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis

Adenosine-to-inosine editing in SNHG3 (c.1746 A > I) drives non-small cell lung (NSCLC) cancer metastasis and docetaxel resistance by enhancing SSRP1 binding and altering fatty acid metabolism. Targeting this hyper-edited RNA may improve cancer therapy.

Shizhen Chen
Amei Zhuo
Lei Yang
ResearchOpen Access02 Sept 2025
Communications Biology

Volume: 8, P: 1-16
Central retinal artery catheterization for retinal artery occlusion with balanced salt solution

Xiangdong Luo
Xiaoying Wang
Xiaoxin Li
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Improving CO₂ desorption performance in monoethanolamine solutions by adding titanium pyrophosphate catalyst

Siming Chen
Linlin Chen
Lei Zhang
ResearchOpen Access04 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
Continuous-wave quantum dot photonic crystal lasers grown on on-axis Si (001)

Fabricating semiconductor photonic lasers based on III-V materials are challenging because of the material mismatch with silicon. Here the authors monolithically grow quantum-dot-based photonic crystal membrane lasers directly on an on-axis silicon substrate.

Taojie Zhou
Mingchu Tang
Huiyun Liu
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-7
Primary sjögren’s syndrome among patients with cerebral infarction

Liping Fan
Chen Wang
Yihong Zhan
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Achieving ultrahigh fatigue resistance in AlSi10Mg alloy by additive manufacturing

An ultrahigh fatigue-resistant AlSi10Mg alloy is achieved by additive manufacturing, with its three-dimensional dual-phase cellular nanostructure acting as a strong volumetric nanocage to inhibit fatigue damage accumulation.

Chengyi Dan
Yuchi Cui
Jian Lu
Research17 Aug 2023
Nature Materials

Volume: 22, P: 1182-1188
Programming gel automata shapes using DNA instructions

Shape transformation without the need for external devices or wires is desirable for soft robotics, but challenging to achieve. Here, the authors report the development of actuators capable of shape changes by polymerization and depolymerization of DNA activator sequences.

Ruohong Shi
Kuan-Lin Chen
Rebecca Schulman
ResearchOpen Access05 Sept 2024
Nature Communications

Volume: 15, P: 1-11
The analysis of different types of anorectal abscesses was conducted using the MRI 3D reconstruction technique

Xutao Ma
Yikun Li
Chen Wang
ResearchOpen Access09 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Genomic landscape of lung adenocarcinoma in East Asians

Genomic and transcriptomic analysis of lung adenocarcinoma (LUAD) in Asia indicates that Asian LUADs have fewer mutations, lower driver prevalence and fewer copy number alterations than European LUADs.

Jianbin Chen
Hechuan Yang
Weiwei Zhai
Research03 Feb 2020
Nature Genetics

Volume: 52, P: 177-186
Physiological and psychological symptom management based on electronic patient-reported outcomes: the TD-WELLBEING randomized clinical trial

Pengyu Jing
Ying Liang
Zhongping Gu
ResearchOpen Access07 Aug 2025
British Journal of Cancer

Volume: 133, P: 937-944
Universal in situ supersaturated crystallization enables 3D printable afterglow hydrogel

Shuman Zhang
Yunliang Ji
Wei Huang
ResearchOpen Access01 Feb 2025
npj Flexible Electronics

Volume: 9, P: 1-10
Electrically pumped continuous-wave III–V quantum dot lasers on silicon

The growth of III–V quantum dot lasers directly onto a silicon substrate aids photonics and electronics integration.

Siming Chen
Wei Li
Huiyun Liu
Research07 Mar 2016
Nature Photonics

Volume: 10, P: 307-311
Sodium tanshinone IIA sulfate adjunct therapy reduces high-sensitivity C-reactive protein level in coronary artery disease patients: a randomized controlled trial

Siming Li
Yang Jiao
Keji Chen
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-10
Clinical features and outcomes of IgG4-related idiopathic orbital inflammatory disease: from a large southern China-based cohort

Jingqiao Chen
Ping Zhang
Huasheng Yang
Research13 Jul 2020
Eye

Volume: 35, P: 1248-1255
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Bats account for 20 per cent of all mammals, these are the only mammals with powered flight, and are among the few animals that echolocate. Here, Seim et al. sequence the genome of the long-lived (>40 years) Brandt’s bat, Myotis brandtiiand provide clues to its evolution, longevity and other traits.

Inge Seim
Xiaodong Fang
Vadim N. Gladyshev
ResearchOpen Access20 Aug 2013
Nature Communications

Volume: 4, P: 1-8
Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

Tetrathiomolybdate (TM) and Cu-ATPases, e.g. Wilson (WLN) protein, affect the efficacy of common anticancer drug cisplatin. Here, the authors show that TM generates a protein dimer with a WLN domain by expelling copper and provide insight into the synergy of TM and cisplatin in cancer chemotherapy.

Tiantian Fang
Wanbiao Chen
Yangzhong Liu
ResearchOpen Access14 Jan 2019
Nature Communications

Volume: 10, P: 1-8
Nucleosome organization of mouse embryos during pre-implantation development

Jitao Zeng
Xiaojuan Tu
Wei He
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal

Biomolecule-metal-organic-frameworks allow for the creation of hybrid materials with desired biological and chemical function. Here, the authors refine the structure-function relationship by identifying the atomic-layer structure of the hybrids and show differences in structure upon different crystallisation pathways.

Linjing Tong
Siming Huang
Gangfeng Ouyang
ResearchOpen Access17 Feb 2022
Nature Communications

Volume: 13, P: 1-9
Methionine is a metabolic dependency of tumor-initiating cells

Elevated activity of the methionine cycle is essential for cancer stem cell tumorigenesis and represents a therapeutic vulnerability.

Zhenxun Wang
Lian Yee Yip
Wai Leong Tam
Research06 May 2019
Nature Medicine

Volume: 25, P: 825-837
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

Elissa J Chesler
Lu Lu
Robert W Williams
Research13 Feb 2005
Nature Genetics

Volume: 37, P: 233-242
Twist piezoelectricity: giant electromechanical coupling in magic-angle twisted bilayer LiNbO₃

Authors bond two layers of LiNbO₃ as an acoustic resonator. With interlayer coupling of fields and modulation by twisted angle, a magic-angle effect is reported, as one mode exhibits huge electromechanical coupling while its twin-mode disappears.

Hulin Yao
Pengcheng Zheng
Xin Ou
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-8
The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

The brown fat-derived neuregulin 4 regulates hepatic lipid homeostasis and whole-body insulin sensitivity

Guo-Xiao Wang
Xu-Yun Zhao
Jiandie D Lin
Research17 Nov 2014
Nature Medicine

Volume: 20, P: 1436-1443
Risk factors for pterygium recurrence based on a retrospective study of 196 patients

Shikun Chen
Mouxin Zhang
Liying Tang
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-7
Simulation and assimilation of the digital human brain

The Digital Brain platform is capable of simulating spiking neuronal networks at the neuronal scale of the human brain. The platform is used to reproduce blood-oxygen-level-dependent signals in both the resting state and action, thereby predicting the visual evaluation scores.

Wenlian Lu
Xin Du
Yicong Zhao
Research19 Dec 2024
Nature Computational Science

Volume: 4, P: 890-898
Plasmonic twinned silver nanoparticles with molecular precision

The structure of nanoparticles strongly influences their properties. Here, the authors use single crystal X-ray diffraction to resolve the crystal structures of Ag₁₃₆ and Ag₃₇₄nanoparticles, enabling the observation of local structure distortion and the lower size limit of surface plasmon resonance.

Huayan Yang
Yu Wang
Nanfeng Zheng
ResearchOpen Access09 Sept 2016
Nature Communications

Volume: 7, P: 1-8
Cytosporone B is an agonist for nuclear orphan receptor Nur77

Yanyan Zhan
Xiping Du
Qiao Wu
Research10 Aug 2008
Nature Chemical Biology

Volume: 4, P: 548-556
A cross-sectional study investigating the L-shaped relationship between urinary albumin creatinine ratio and overweight/obesity in children and adolescents

Zhengjiu Cui
Xiaorui Chen
Bin Yuan
ResearchOpen Access26 Apr 2025
Scientific Reports

Volume: 15, P: 1-14
Deep neural network-enabled dual-functional wideband absorbers

Jing Li
BinYi Ma
Mengwei Li
ResearchOpen Access24 Oct 2024
Scientific Reports

Volume: 14, P: 1-15
LncRNA MACC1-AS1 induces gemcitabine resistance in pancreatic cancer cells through suppressing ferroptosis

Jiyun Zhu
Zehao Yu
Siming Zheng
ResearchOpen Access27 Feb 2024
Cell Death Discovery

Volume: 10, P: 1-14
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling

Guanylate-binding proteins (GBP) have a function in inflammasome formation and pathogen defence. Here the authors show that these GBP proteins are able to kill certain bacteria and promote selective inflammasome activation and that this is mediated by specific GBP protein regions.

Shouya Feng
Daniel Enosi Tuipulotu
Si Ming Man
ResearchOpen Access29 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Protein interactions, network pharmacology, and machine learning work together to predict genes linked to mitochondrial dysfunction in hypertrophic cardiomyopathy

Jia-lin Chen
Di Xiao
Zhong-gui Shan
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-23
Clinical characteristics and removal approaches of tracheal and bronchial foreign bodies in elders

Ping-Yang Hong
Ling Wang
Xiao-Bin Zhang
ResearchOpen Access25 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Author Correction: Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes

Yinglei Liu
Yamin Zhao
Hongjian Chen
Amendments and CorrectionsOpen Access27 Feb 2024
Scientific Reports

Volume: 14, P: 1
Modelling and optimization of Ge/GaAs uni-travelling carrier photodiodes

Yutong Zhang
Mengxun Bai
Huiyun Liu
ResearchOpen Access15 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development

Fan Zhai
Siming Kong
Jie Qiao
ResearchOpen Access24 Sept 2024
Cell Discovery

Volume: 10, P: 1-9
A future for digital public goods for monitoring SDG indicators

Dong Liang
Huadong Guo
Thorsten Jelinek
ResearchOpen Access07 Dec 2023
Scientific Data

Volume: 10, P: 1-10
Room-temperature continuous-wave topological Dirac-vortex microcavity lasers on silicon

The first topological Dirac-vortex microcavity lasers on silicon are experimentally realized. Operating under room-temperature continuous-wave conditions, these lasers mark an important step toward integrating topological lasers with CMOS-compatible optoelectronic systems.

Jingwen Ma
Taojie Zhou
Xiankai Sun
ResearchOpen Access24 Oct 2023
Light: Science & Applications

Volume: 12, P: 1-8
Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes

Yinglei Liu
Yamin Zhao
Hongjian Chen
ResearchOpen Access18 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Encapsulating and stabilizing enzymes using hydrogen-bonded organic frameworks

We present a protocol for the encapsulation and stabilization of enzymes by using hydrogen-bonded organic frameworks (HOFs)—enzyme@HOF-101—along with procedures for their material characterization and testing of their biocatalytic performance.

Guosheng Chen
Siming Huang
Gangfeng Ouyang
Protocols17 May 2023
Nature Protocols

Volume: 18, P: 2032-2050
Bacterial lipopolysaccharide related genes signature as potential biomarker for prognosis and immune treatment in gastric cancer

Tianyi Yuan
Siming Zhang
Jue Gu
ResearchOpen Access23 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
Effects of phosphorous and antimony doping on thin Ge layers grown on Si

Xueying Yu
Hui Jia
Huiyun Liu
ResearchOpen Access04 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing

In this study, the authors have investigated if the implantation of fibrin gel loaded with platelet-rich plasma-derived exosomes is a feasible strategy to treat rotator cuff injuries. In fact, this strategy proved to promote tendon repair and healing outcomes in a rabbit model of rotator cuff injury.

Molin Li
Lin Shi
Yuexiang Wang
ResearchOpen Access20 Feb 2024
Communications Biology

Volume: 7, P: 1-15
A personalized mRNA signature for predicting hypertrophic cardiomyopathy applying machine learning methods

Jue Gu
Yamin Zhao
Hongzhuan Sheng
ResearchOpen Access24 Jul 2024
Scientific Reports

Volume: 14, P: 1-12

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