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Singla et al. report the secondary analysis of the Scaling Up Maternal Mental healthcare by Increasing access to Treatment (SUMMIT) trial.

Legionella effector LnaB, a recently identified actin-activated AMPylase, mediates phosphoryl-AMPylation in a yet-unknown manner. Here the authors unveil a two-step catalytic process involving dual ATPase–AMPylase activity based on structural studies, providing a biochemical basis for AMPylation.

Cui and colleagues identify the chromatin organizer protein SATB1 as a critical regulator of quiescence in stem-like progenitor CD8⁺ T cells that arise during chronic viral infection and cancer.

Heating-resistive flexible electronics is promising, yet challenging. Here, the authors report a direct printing and writing strategy for refractory entropy-alloy-based flexible sensors with sensitivity over a broad temperature range, enabling real-time monitoring of morphing aircrafts in harsh environments.

Neel domain walls are typically stabilized by an interfacial Dzyaloshinskii-Moriya interaction, with a chirality that is fixed by the sample materials. Here, Song, Huang and coauthors demonstrate the existence of two bistable Néel domain wall states with opposite chiralities, and the switching between these via magnetic field pulses

The bacterial pathogen Legionella pneumophila secretes effectors that affect protein ubiquitination within host cells, involving production of phosphoribosyl ubiquitin (PR-Ub). Here, the authors identify additional effectors that convert PR-Ub back into functional ubiquitin, thus maintaining ubiquitin homeostasis in infected cells.

Kuang, Dou et al. show that upon Salmonella Typhimurium infection in mice, macrophages release extracellular vesicles (EVs) that harbor iron-uptake receptors. By sequestering iron via a humoral mechanism, these EVs limit bacterial growth and thereby protect against infection.

A rare variant burden analytical framework for Mendelian diseases was developed and applied to data from the 100,000 Genomes Project, identifying 69 probable new disease–gene associations.

While the metabolic benefits of physical exercise are well known, it is less clear whether exercise can prevent cardiac damage in diet-induced obesity. Here, the authors show that while exercise prevented weight gain in mice, it surprisingly worsened heart damage due to excessive lipid uptake and lipotoxicity.

Liu et al. show that microRNA394 is expressed in shoot apex and strictly inhibits LCR accumulation in leaf axils, to attenuate LCR mediated TPL degradation and activate the REV and STM pathway, which is essential for axillary meristem initiation in Arabidopsis.

Here, authors report an inter-site structural heterogeneity induced effect of hierarchical single atom Fe catalysts for robust oxygen reduction. Dynamic evolutions and insights into structure-activity relationship are presented.

Integrated single-cell atlases of human fetal cerebella and MBs show potential cell populations predisposed to transformation and regulatory circuitries underlying tumour cell states and oncogenesis, highlighting hitherto unrecognized transitional progenitor intermediates predictive of disease prognosis.

A dataset of coding variation, derived from exome sequencing of nearly one million individuals from a range of ancestries, provides insight into rare variants and could accelerate the discovery of disease-associated genes and advance precision medicine efforts.

It is not yet clear how ubiquitously-expressed proteins can cause the selective degeneration of particular populations of neurons, such as in spinocerebellar ataxia type 17, SCA17, which results from a CAG trinucleotide repeat expansion in the ubiquitously expressed transcription factor TBP. Here, the authors show that mutant TBP suppresses the cerebellum-enriched transcription of Inpp5a and link altered levels of INPP5A to the selective degeneration of cerebellar neurons.

Thermocatalytic alkynol semi-hydrogenation often uses high-pressure H₂ and Pd-based catalysts. Here, using a Cu-based electrode, the authors investigate the electrocatalytic alkynol semi-hydrogenation to alkenols with water as the hydrogen source.

Circular RNAs (circRNA) is a class of non-coding RNAs that can regulate gene translation and function. Here the authors show that a circRNA, circNDUFB2, is downregulated in non-small cell lung cancer tissues, and likely contributes to anti-tumor immunity by regulating both degradation of oncoproteins and induction of innate immunity.

Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.

A polymeric protein complex consisting of a newly identified magnetoreceptor protein and known magnetoreception-related photoreceptor cryptochromes exhibits spontaneous alignment in magnetic fields.

Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

The authors developed a metabolic labeling method via incorporation of allyl-SAM analogs to profile transcriptome-wide m⁶A at base resolution, which enables identification of m⁶A motifs and clustered m⁶A sites.

Circular RNAs are known to regulate cancer. Here, the authors show that the circular RNA circTP63 promotes lung squamous cell carcinoma by competing with endogenous RNA to upregulate FOXM1.

Type 1 as well as type 2 diabetes are characterized by a loss of insulin-producing β-cells. Here the authors show that the FDA-approved drug neratinib has beneficial effects on β-cell survival, insulin secretion, and glycemic control in mouse models of diabetes.

Genome-wide meta-analysis of SARS-CoV-2 susceptibility and severity phenotypes in up to 756,646 samples identifies a rare protective variant proximal to ACE2. A 6-SNP genetic risk score provides additional predictive power when added to known risk factors.

Trans-ancestry genome-wide analyses identify multiple loci associated with ascending aortic diameter. A polygenic score constructed from these loci predicted prevalent risk of thoracic aortic aneurysm in independent populations.

The heterogeneity of fibroblasts in normal colon mucosa and colorectal cancer (CRC) is examined using single cell data, showing their potential function in normal gut homeostasis and in CRC.