Nature Search

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Site-selective protein editing by backbone extension acyl rearrangements

A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-peptide backbone. BEAR reactions represent a general strategy to install extended backbones into genetically encoded proteins and peptides expressed in cells.

Leah T. Roe
Isabel M. Piper
Alanna Schepartz
Research21 Aug 2025
Nature Chemical Biology

Volume: 21, P: 1621-1630
Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody–STING agonist conjugates

A modular anti-albumin nanobody conjugated to a STING agonist enhances antitumour immunity by improving pharmacokinetics, tumour accumulation and immune responses, inhibiting murine tumour growth and enhancing cancer immunotherapies.

Blaise R. Kimmel
Karan Arora
John T. Wilson
ResearchOpen Access11 Jun 2025
Nature Biomedical Engineering

P: 1-21
Compact radio source 1413 + 135 is a far-IR extragalactic object

C. A. Beichman
G. Neugebauer
P. M. Harvey
Research29 Oct 1981
Nature

Volume: 293, P: 711-713
Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial

Ataxia telangiectasia and Rad3-related kinase (ATR) is a rational radiosensitization target. This trial evaluates the combination of the ATR inhibitor, ceralasertib, with palliative radiotherapy in 27 patients with advanced solid tumors.

Magnus T. Dillon
Emmanuel C. Patin
Kevin J. Harrington
ResearchOpen Access01 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity

Sydnor et al. developed a new tractography atlas of thalamocortical structural connections and applied it to three youth samples. They uncovered coordinated development between thalamic connectivity and hierarchical cortical plasticity in humans.

Valerie J. Sydnor
Joëlle Bagautdinova
Theodore D. Satterthwaite
ResearchOpen Access04 Jul 2025
Nature Neuroscience

Volume: 28, P: 1772-1786
Cavitation upon low-speed solid–liquid impact

A solid hitting a liquid surface normally creates a region of high pressure at the solid-liquid contact area. Now, it is shown that for a flat-bottomed cylinder hitting a liquid at low-enough impact speed, the local pressure is sufficiently low to cause the liquid to cavitate.

Nathan B. Speirs
Kenneth R. Langley
Sigurdur T. Thoroddsen
ResearchOpen Access13 Dec 2021
Nature Communications

Volume: 12, P: 1-7
Assessing and improving reliability of neighbor embedding methods: a map-continuity perspective

Visualisation methods such as t-SNE and UMAP are widely used in research, yet they often lead to misinterpretations due to distortion. The authors introduce a statistical framework to detect intrinsic map discontinuities and improve the reliability of interpretations.

Zhexuan Liu
Rong Ma
Yiqiao Zhong
ResearchOpen Access30 May 2025
Nature Communications

Volume: 16, P: 1-16
Stimulation of Renal Growth in the Rat by Folic Acid

D. M. TAYLOR
G. THRELFALL
A. T. BUCK
Research29 Oct 1966
Nature

Volume: 212, P: 472-474
Binocular, Directionally Selective Neurones, Possibly Involved in the Optomotor Response of Insects

T. S. COLLETT
A. D. BLEST
Research17 Dec 1966
Nature

Volume: 212, P: 1330-1333
Natural products as inspiration for the development of asymmetric catalysis

Justin T. Mohr
Michael R. Krout
Brian M. Stoltz
Reviews17 Sept 2008
Nature

Volume: 455, P: 323-332
Optical Polarization Measurements of Pulsar NP 0532

W. J. COCKE
M. J. DISNEY
T. GEHRELS
Research09 Aug 1969
Nature

Volume: 223, P: 576-578
Experiments in catastrophe

J. M. T. Thompson
Research03 Apr 1975
Nature

Volume: 254, P: 392-395
Impacts of soret and dufour possessions on micropolar fluid past a stretching sheet in a porous medium

Shakila Ahamedsheriff
Vijayaragavan Rajaram
Imed Kedim
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-18
Finding of a sex pheromone source by gypsy moths released in the field

C. T. David
J. S. Kennedy
A. R. Ludlow
Research30 Jun 1983
Nature

Volume: 303, P: 804-806
Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages

Dormant liver stages of Plasmodium vivax complicate malaria elimination efforts by causing relapses that obscure the efficacy of antimalarial treatments. Here, the authors develop a high-throughput amplicon sequencing assay to reconstruct P. vivax lineages, demonstrating its capacity for geospatial infection tracking, and distinguishing recurrent malaria caused by new infections versus untreated dormant liver stages.

Mariana Kleinecke
Edwin Sutanto
Sarah Auburn
ResearchOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Transformation and Hydrolysis of D-Glucono-γ and δ-Lactone

T. TAKAHASHI
M. MITSUMOTO
Research24 Aug 1963
Nature

Volume: 199, P: 765-767
Gradient vortex dynamics in 3D-weak turbulence

Rubens A. Sautter
Reinaldo R. Rosa
Flavio H. Fenton
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-18
A fungal plant pathogen discovered in the Devonian Rhynie Chert

Here, the authors describe a pathogenic fungus from a 400-million-year-old fossil plant from the Devonian Rhynie Chert in Scotland. They use advanced imaging methods to determine that the fungus belongs to the sac fungi, the most diverse group of Fungi today.

Christine Strullu-Derrien
Tomasz Goral
David L. Hawksworth
ResearchOpen Access01 Dec 2023
Nature Communications

Volume: 14, P: 1-10
Production of Antibiotics by Fusaria

A. H. COOK
S. F. COX
M. S. LACEY
Research05 Jul 1947
Nature

Volume: 160, P: 31-32
No evidence of rings around Neptune

J. L. Elliot
D. J. Mink
O. G. Franz
Research10 Dec 1981
Nature

Volume: 294, P: 526-529
Use of Synthetic Polyglucose for Density-Gradient Centrifugation of Viruses

S. I. OROSZLAN
S. RIZVI
P. T. MORA
Research23 May 1964
Nature

Volume: 202, P: 780-781
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A search for human influences on the thermal structure of the atmosphere

B. D. Santer
K. E. Taylor
S. Tett
Research04 Jul 1996
Nature

Volume: 382, P: 39-46
Predictive biophysical neural network modeling of a compendium of in vivo transcription factor DNA binding profiles for Escherichia coli

The authors describe BoltzNet, a neural network that learns the energy of transcription factor (TF)-DNA binding from genomic data and can be used to design new binding sites. They report the in vivo mapping and BoltzNet modeling of 139 E. coli TFs.

Patrick Lally
Laura Gómez-Romero
James E. Galagan
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-16
Submillimetre Absorption and Dispersion of Liquid Water

J. E. CHAMBERLAIN
G. W. CHANTRY
G. WYLLIE
Research21 May 1966
Nature

Volume: 210, P: 790-791
Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis

The COVID-19 pandemic has raised concerns about increased neuropsychiatric conditions in children and youths, with potential links to SARS-CoV-2 infection. Here, the authors analyze EHR data from 25 institutions, showing that COVID-19 positive children and youths have a modestly increased risk of developing neuropsychiatric conditions, such as anxiety, depression, and ADHD, compared to those who tested negative.

Yiwen Lu
Jiayi Tong
Yong Chen
ResearchOpen Access24 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Autonomic physiological coupling of the global fMRI signal

The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

Taylor Bolt
Shiyu Wang
Catie Chang
Research07 May 2025
Nature Neuroscience

Volume: 28, P: 1327-1335
Coevolution of craton margins and interiors during continental break-up

By integrating geological observations, statistical analysis, geodynamic simulations and landscape-evolution models, a physical model is proposed to link the coevolution of craton margins and interiors with continental rifting.

Thomas M. Gernon
Thea K. Hincks
Anne Glerum
ResearchOpen Access07 Aug 2024
Nature

Volume: 632, P: 327-335
On the origin of the universal dielectric response in condensed matter

K. L. Ngai
A. K. Jonscher
C. T. White
Research18 Jan 1979
Nature

Volume: 277, P: 185-189
Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery

The authors use artificial intelligence approaches to explore the predictive value of whole exome sequencing in forecasting clinical outcomes following surgery for congenital heart defects. Findings include that damaging genotypes in chromatin-modifying and cilia-related genes are associated with an increased risk of adverse post-operative outcomes such as mortality, cardiac arrest, and prolonged mechanical ventilation.

W. Scott Watkins
Edgar J. Hernandez
Martin Tristani-Firouzi
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Ice retreat in Wilkes Basin of East Antarctica during a warm interglacial

Uranium isotopes in subglacial precipitates from the Wilkes Basin of the East Antarctic Ice Sheet reveal ice retreat during a warm Pleistocene interglacial period about 400,000 years ago.

T. Blackburn
G. H. Edwards
J. T. Babbe
Research22 Jul 2020
Nature

Volume: 583, P: 554-559
Optical Polarization of the Crab Nebula Pulsar

W. J. COCKE
M. J. DISNEY
T. GEHRELS
Research26 Sept 1970
Nature

Volume: 227, P: 1327-1329
Isotopic and geochemical studies of nodules in kimberlite have implications for the lower continental crust

M. T. McCulloch
R. J. Arculus
J. Ferguson
Research11 Nov 1982
Nature

Volume: 300, P: 166-169
Down-converted photon pairs in a high-Q silicon nitride microresonator

Spontaneous parametric down-conversion was used to generate narrowband photon pairs with a high spectral brightness in a high-Q silicon nitride microresonator.

Bohan Li
Zhiquan Yuan
Kerry Vahala
ResearchOpen Access19 Mar 2025
Nature

Volume: 639, P: 922-927
Effect of Small Protrusions on Mass Transport to a Rotating-Disk Electrode

G. T. ROGERS
K. J. TAYLOR
Research14 Dec 1963
Nature

Volume: 200, P: 1062-1064
High temperature rise dominated cracking mechanisms in ultra-ductile and tough titanium alloy

Specific titanium alloys combine transformation-induced plasticity and twinning-induced plasticity for improved work hardening. Here, the authors show that these alloys also have an ultra-large fracture resistance and an unexpected fracture mechanism via dynamic recrystallization and local melting in a deformation band.

L. Choisez
L. Ding
P. J. Jacques
ResearchOpen Access30 Apr 2020
Nature Communications

Volume: 11, P: 1-8
A complex multi-notch astronomical filter to suppress the bright infrared sky

The night sky viewed from Earth is very bright at infrared wavelengths due to atmospheric emission, making land-based astronomy difficult in this spectral region. Here, a photonic filter is demonstrated to suppress this unwanted light, opening new paths to infrared astronomy with current and future telescopes.

J. Bland-Hawthorn
S.C. Ellis
C. Trinh
Research06 Dec 2011
Nature Communications

Volume: 2, P: 1-7
Further Observations of Pulsating Radio Sources at 13 cm

R. D. EKERS
A. T. MOFFET
Research23 Nov 1968
Nature

Volume: 220, P: 756-761
Similarity of the crystal and solution structure of yeast tRNA^Phe

G. T. Robillard
C. E. Tarr
H. J. C. Berendsen
Research01 Jul 1976
Nature

Volume: 262, P: 363-369
Nickel Content of Pacific Ocean Cores

FRANCIS T. BONNER
ALZIRA SOARES LOURENCO
Research28 Aug 1965
Nature

Volume: 207, P: 933-935
Timing and scintillation observations of the fast pulsar in CTB80

A. S. Fruchter
J. H. Taylor
A. Wolszczan
Research07 Jan 1988
Nature

Volume: 331, P: 53-54
Engineering ultra-strong electron-phonon coupling and nonclassical electron transport in crystalline gold with nanoscale interfaces

The electron-phonon interaction in gold and silver is weak, which leads to both their high conductivity and lack of conventional superconductivity. Here, Kumbhakar and coauthors find, using point contact spectroscopy, that the electron-phonon interaction in a nanostructured gold-silver film can be enhanced by over two orders of magnitude compared to the constituent elements.

Shreya Kumbhakar
Tuhin Kumar Maji
Arindam Ghosh
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-9
Seismic full-waveform tomography of active cratonic thinning beneath North America consistent with slab-induced dripping

Drip-like features imaged in a seismic tomography model are consistent with extensive ongoing thinning of cratonic lithosphere beneath North America.

Junlin Hua
Stephen P. Grand
Hejun Zhu
Research28 Mar 2025
Nature Geoscience

Volume: 18, P: 358-364
Eighteen million years of diverse enamel proteomes from the East African Rift

The isolation of dental proteins from fossils deposited 1.5 million to 18 million years ago in the Turkana Basin in Kenya, a tropical region, demonstrate the promise of dental enamel for palaeoproteomic and evolutionary studies.

Daniel R. Green
Kevin T. Uno
Timothy P. Cleland
ResearchOpen Access09 Jul 2025
Nature

Volume: 643, P: 712-718
Targeting of non-lg sequences in place of the V segment by somatic hyper mutation

J. YÃ©lamos
N. Klix
C. Milstein
Research20 Jul 1995
Nature

Volume: 376, P: 225-229
Filamin C dimerisation is regulated by HSPB7

Filamin C is a key actin-binding protein involved in cardiomyopathies and musculoskeletal disorders. Here, Wang et al reveal that it interacts with the heat shock protein HSPB7 under biomechanical stress, forming a stable hetero-dimer which is regulated by phosphorylation.

Zihao Wang
Guodong Cao
Justin L. P. Benesch
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-16
Hydrogen Bonding in Phenols

T. CAIRNS
G. EGLINTON
Research10 Nov 1962
Nature

Volume: 196, P: 535-537
The strongly driven Fermi polaron

Fermi polarons are quasiparticles formed by impurities immersed in a Fermi gas. An experiment in an ultracold fermionic gas now shows how to control their properties with a tunable radio-frequency field.

Franklin J. Vivanco
Alexander Schuckert
Nir Navon
ResearchOpen Access07 Apr 2025
Nature Physics

Volume: 21, P: 564-569
Relations between Structure, Metabolism and Toxicity of the ‘Cyclodiene’ Insecticides

G. T. BROOKS
A. HARRISON
Research22 Jun 1963
Nature

Volume: 198, P: 1169-1171

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