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For fertilization, sperm migrate through the utero-tubal junction (UTJ) and bind to the zona pellucida (ZP). Here the authors identify sperm expressed GALNTL5 as a GalNAc binding factor required for migration though the UTJ and attachment to the ZP.

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Pancreatic alpha cells resist stress better than beta cells, but the mechanisms underlying this observation are unclear. Here, the authors show that Sec31A regulates alpha but not beta cell survival under stress by linking ER-Golgi transport to insulin signaling pathways.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Studying embryo implantation remains challenging due to limited in situ access. Here, the authors demonstrate implantation and embryogenesis on an ex vivo uterine system that enables a scalable implantation screening by modulating maternal-embryonic signaling.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Chiba & Ide et al. used the data from a Japanese longitudinal cohort study to investigate the suicide risk in the general population before and after the COVID-19 pandemic.

Here, the authors perform cross-trait analyses of respiratory and cardiometabolic diseases, rheumatoid arthritis, and smoking and identify negative genetic correlations between respiratory and cardiometabolic diseases in individuals of East Asian ancestry, in opposition from the positive association in European ancestry individuals.

Here, the authors develop a PMO-based heteroduplex oligonucleotide technology that enhances PMO delivery to tissues and normalizes motor/cardiac function and CNS symptoms in a mouse model of Duchenne muscular dystrophy.

The synchronous activity has a crucial for brain function. Here, the authors established an experimental setup enabling simultaneous recording and stimulation at a single-neuron level in cultured neuronal networks and explored interaction between single-neuron activity and network-wide activity.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Multiferroics are promising for their simultaneous ferroelectricity and magnetism, although in some of the most promising compounds the ferroelectric polarization remains small. Here, the authors show that applying external pressure to the multiferroic TbMnO₃leads to a high ferroelectric polarization.

Magnetic reconnection is the process of releasing energy by magnetized and space plasma. Here the authors report experimental observation of magnetic reconnection in laser-produced plasma and the role of electron scaling on reconnection.

Authors develop and present RIBEA (Rapid and Integrated Bacterial Evolution Analysis), an approach that combines lab-based evolution experiments, genome sequencing and in vivo testing, to monitor long-term evolution or bacterial pathogenicity and antimicrobial resistance, in the context of Klebsiella pneumoniae.

Resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) is prevalent. Here the authors establish a biobank of patient-derived EGFR-mutant lung cancer organoids and identify a subgroup of EGFR-TKI-resistant lung adenocarcinoma organoids, which exhibit a basal-shift phenotype and vulnerability to CDK4/6 inhibitors.

The role of autoantibodies in bullous pemphigoid (BP) and their impact on keratinocytes and the response to BP pathology remains underexplored. By leveraging transcriptomics analysis and large-scale protein assays, here the authors identify keratinocyte MyD88 as a regulator of the pro-inflammatory response in BP, uncovering the role of keratinocytes in this disease pathology.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Polyunsaturated fatty acids (PUFAs) are attracting considerable interest because of their diverse structures and properties. Now a method to access a wide array of PUFAs by full solid-phase synthesis has been developed and used to discover an anti-inflammatory fatty acid.

The underlying mechanisms driving colorectal cancer (CRC) through the serrated route are largely unknown. Here, the authors show that reduced aPKC levels increase cholesterol biosynthesis to promote aggressiveness in serrated tumours and targeting this pathway reduces tumourigenesis in preclinical models of serrated CRC.

Magnetically intercalated transition metal dichalcogenides provide a platform to study the interplay of magnetism, electronic band structures, and correlations. Here the authors demonstrate a nearly magnetization-free anomalous Hall effect, collinear antiferromagnetism and non-Fermi liquid behavior in V_1/3NbS₂.

Designer enzymes comprising an abiological molecule incorporated into a natural protein have been reported, but the use of proteins as ligands to construct abiological (multinuclear) metal centers is rare. Here, the authors report a designer multi-metalloenzyme with extrinsic and intrinsic functions obtained by grafting a synthetic trinuclear zinc complex inside a human cytokine macrophage migration inhibitory factor scaffold.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Ferrotoroidic order has long been suggested as the fourth form of ferroic orders, in addition to known ferroelastic, ferroelectric and ferromagnetic order. Yamaguichi and Kimura propose the existence of a new glass state in solids with ferrotoroidic order and demonstrate the concept in Ni_0.4Mn_0.6TiO₃.

Here, the authors capture the mitotic chromosome assembly as molecular events of nucleosomes in living human cells, investigating how condensins and nucleosome-nucleosome interactions constrain chromatin during the assembly process in mitosis.