Nature Search

Engineering bi-directional chemically-modulated synthetic condensates for cellular control

Tools for precisely manipulating phase-separated condensates remain limited. Here authors present an engineered system based on the androgen receptor, where clinically used drugs can be used to control the formation and dissolution of synthetic condensates, subsequently allowing control over various cellular processes.

Ni Zhen
Yue Yan
Jingjing Xie
ResearchOpen Access17 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Widespread ilmenite contributions to the surface water cycle in lunar Procellarum KREEP Terrane

The study shows that lunar ilmenite preserves less solar wind-generated water than silicate minerals, likely due to faster water escape. This finding suggests that ilmenite may critically influence surface water variations within the lunar Procellarum KREEP Terrane.

Yuchen Xu
Liyu Shan
Xianhua Li
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-10
Reprogramming the tumor microenvironment with c-MYC-based gene circuit platform to enhance specific cancer immunotherapy

Targeting tumors with c-MYC dysregulation is very challenging due to low MYC expression and intratumor heterogeneity. Here, the authors report a MYC-based gene circuitry that enhances immunotherapy response and tumor killing in bladder cancer.

Hengji Zhan
Hongjin Wang
Xu Chen
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Oriented graphene nanoribbons embedded in hexagonal boron nitride trenches

Graphene nanoribbons are promising candidates for 2D material electrical interconnects; however, the top-down fabrication of nanoribbons has remained a challenge. Here, Chenet al. have used a hexagonal boron nitride template to grow narrow, integrated graphene nanoribbons with small bandgaps.

Lingxiu Chen
Li He
Mianheng Jiang
ResearchOpen Access09 Mar 2017
Nature Communications

Volume: 8, P: 1-6
Remodelling autoactive NLRs for broad-spectrum immunity in plants

Cleavage by pathogen-derived proteases of an engineered chimeric protein activates its plant immune receptor component, enabling broad-spectrum resistance to pathogens in plants.

Junzhu Wang
Tianyuan Chen
Yule Liu
Research16 Jul 2025
Nature

Volume: 645, P: 737-745
Neoadjuvant gemcitabine–cisplatin plus tislelizumab in persons with resectable muscle-invasive bladder cancer: a multicenter, single-arm, phase 2 trial

Li et al. perform a phase 2 single-arm clinical trial of neoadjuvant chemotherapy plus checkpoint blockade in participants with resectable muscle-invasive bladder cancer and conduct genomic and transcriptomic profiling to describe molecular subtypes.

Kaiwen Li
Wenlong Zhong
Tianxin Lin
Research10 Sept 2024
Nature Cancer

Volume: 5, P: 1465-1478
Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth

Delivering therapeutics to the brain is challenging because of the hard-to-cross blood–brain barrier. Here, the authors show that HER3, which is expressed on the surface of many metastatic tumours, is associated with the brain endothelium and can drive accumulation of HER3-targeted nanoparticles within the brain, for therapy against HER3-positive tumours.

Felix Alonso-Valenteen
Simoun Mikhael
Lali K. Medina-Kauwe
ResearchOpen Access21 Feb 2025
Nature Nanotechnology

Volume: 20, P: 683-696
Temporal shifts in 24 notifiable infectious diseases in China before and during the COVID-19 pandemic

Public health and social measures for COVID-19 also impacted the incidence of other infectious diseases. In this study, the authors characterise the impacts of these measures on 24 notifiable infectious diseases in China until December 2023.

Kangguo Li
Jia Rui
Tianmu Chen
ResearchOpen Access08 May 2024
Nature Communications

Volume: 15, P: 1-14
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming

The mitochondrial unfolded protein response is shown to inhibit pluripotency during somatic cell reprogramming and to inhibit the mesenchymal-to-epithelial transition through c-Jun-mediated histone acetylation.

Zhongfu Ying
Yanmin Xin
Xingguo Liu
Research09 Apr 2025
Nature Metabolism

Volume: 7, P: 940-951
ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency

Here the authors identify ZIC2 and ZIC3 as key regulators of human primed pluripotency which recruit BRG1 to open primed hESC-specific enhancers.

Ishtiaque Hossain
Pierre Priam
William A. Pastor
ResearchOpen Access02 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Microenvironment reconstitution of highly active Ni single atoms on oxygen-incorporated Mo₂C for water splitting

The comprehensive understanding of complex catalytic mechanisms under harsh reaction conditions for efficient bifunctional single-atom electrocatalysts remain challenging. Here the authors found microenvironment reconsitution of highly active Ni single atoms on oxygen-incorporated Mo2C for water splitting.

Mengyun Hou
Lirong Zheng
Chen Chen
ResearchOpen Access13 Feb 2024
Nature Communications

Volume: 15, P: 1-13
A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

An automated deep-learning pipeline for chest-X-ray-image standardization, lesion visualization and disease diagnosis can identify viral pneumonia caused by COVID-19, assess its severity, and discriminate it from other types of pneumonia.

Guangyu Wang
Xiaohong Liu
Tianxin Lin
Research15 Apr 2021
Nature Biomedical Engineering

Volume: 5, P: 509-521
Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis

Yuchao Feng
Shu Zhang
Xia Fan
ResearchOpen Access31 Jul 2025
npj Science of Food

Volume: 9, P: 1-16
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair

Xinyuan Li
Chunlin Zhang
Xin Gou
ResearchOpen Access10 Jul 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-21
A Transformer-LSTM-SVR hybrid model for AI-driven emotional optimization in NEV embedded interior systems

Zongming Liu
Xuhui Chen
Xiayan Qin
ResearchOpen Access18 Aug 2025
Scientific Reports

Volume: 15, P: 1-31
Directing curli polymerization with DNA origami nucleators

Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins.

Xiuhai Mao
Ke Li
Chao Zhong
ResearchOpen Access27 Mar 2019
Nature Communications

Volume: 10, P: 1-10
Room-temperature low-threshold avalanche effect in stepwise van-der-Waals homojunction photodiodes

The avalanche or carrier-multiplication effect has the potential to improve the performance of photodetectors and solar cells, but usually requires high threshold energies. Here, the authors report stepwise WSe₂ homojunctions exhibiting threshold energies approaching the semiconductor bandgap at room temperature.

Hailu Wang
Hui Xia
Wei Lu
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-9
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

Mechanism of lymph node (LN) metastasis induced by tumor associated macrophages (TAMs) remains unclear. Here they demonstrate that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression.

Changhao Chen
Wang He
Tianxin Lin
ResearchOpen Access20 Sept 2018
Nature Communications

Volume: 9, P: 1-18
Pristine PN junction toward atomic layer devices

Hui Xia
Man Luo
Wei Lu
ResearchOpen Access06 Jun 2022
Light: Science & Applications

Volume: 11, P: 1-8
Author Correction: A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

Guangyu Wang
Xiaohong Liu
Tianxin Lin
Amendments and Corrections29 Jul 2021
Nature Biomedical Engineering

Volume: 5, P: 943
Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal

Pengcheng Chen
Chaowei Wang
Yong Zhang
ResearchOpen Access15 Jul 2021
Light: Science & Applications

Volume: 10, P: 1-7
Precisely aligned graphene grown on hexagonal boron nitride by catalyst free chemical vapor deposition

Shujie Tang
Haomin Wang
Mianheng Jiang
ResearchOpen Access16 Sept 2013
Scientific Reports

Volume: 3, P: 1-7
Programmable and printable Bacillus subtilis biofilms as engineered living materials

Co-opting the amyloid machinery from Bacillus subtilis, engineering of TasA fusion proteins enables the assembly of functionalized biofilms with tunable physicochemical properties that are amenable to 3D printing and microencapsulation techniques.

Jiaofang Huang
Suying Liu
Chao Zhong
Research03 Dec 2018
Nature Chemical Biology

Volume: 15, P: 34-41
Decoding of polar-coded OFDM systems over multipath fading channels with interleaving and channel state information

Mingbao Wu
Yi Yu
Zhian Zheng
ResearchOpen Access05 Dec 2024
Scientific Reports

Volume: 14, P: 1-10
Structural insights into ligand recognition and activation of human purinergic receptor P2Y14

Quanchang Gu
Zhenyu Lv
Jiangyun Wang
CorrespondenceOpen Access13 May 2025
Cell Discovery

Volume: 11, P: 1-4
Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

Yuchen Li
Jiayi Zhou
Wenhao Liao
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
The epigenetic state of the cell of origin defines mechanisms of leukemogenesis

Zhiheng Li
Sara Fierstein
R. Grant Rowe
Research01 Oct 2024
Leukemia

Volume: 39, P: 87-97
Experimental investigation of seismic performance of precast concrete shear walls with overlapping U-bar loop connections

Feng Chen
Zhiwu Yu
Chenxing Cui
ResearchOpen Access31 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
Tumor-associated neutrophils suppress CD8⁺ T cell immunity in urothelial bladder carcinoma through the COX-2/PGE2/IDO1 Axis

Yi Ouyang
Wenlong Zhong
Tianxin Lin
Research17 Jan 2024
British Journal of Cancer

Volume: 130, P: 880-891
The tumour-associated stroma correlates with poor clinical outcomes and immunoevasive contexture in patients with upper tract urothelial carcinoma: results from a multicenter real-world study (TSU-01 Study)

Longhao Xu
Wenlong Zhong
Tianxin Lin
Research17 Nov 2022
British Journal of Cancer

Volume: 128, P: 310-320
Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1

Tianxin Wang
Wenqin Tang
Jiangyun Wang
Correspondence14 May 2024
Cell Research

Volume: 34, P: 590-593
Photonic slide rule with metasurfaces

Metasurface-based photonic slide rule enables the simultaneous resolving of unknown photons’ wavelength and polarization state in mid-infrared.

Feilong Yu
Jin Chen
Wei Lu
ResearchOpen Access29 Mar 2022
Light: Science & Applications

Volume: 11, P: 1-12
Configurable circular-polarization-dependent optoelectronic silent state for ultrahigh light ellipticity discrimination

Based on the configurable circular-polarization-dependent optoelectronic silent state, our integrated circular polarization detector achieves a near-infinite circular polarization extinction ratio and an ultralow noise equivalent light ellipticity difference of 0.009° Hz^−1/2.

Yonghao Bu
Xiansong Ren
Xiaoshuang Chen
ResearchOpen Access14 Jul 2023
Light: Science & Applications

Volume: 12, P: 1-10
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer

Kanghua Xiao
Shengmeng Peng
Tianxin Lin
ResearchOpen Access08 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-13
Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3

Fahui Li
Linhua Tai
Jiangyun Wang
Correspondence09 Jan 2024
Cell Research

Volume: 34, P: 323-326
Effect of dissolved humic acids and coated humic acids on tetracycline adsorption by K₂CO₃-activated magnetic biochar

Meifang Li
Ping Wang
Shaoheng Liu
ResearchOpen Access08 Nov 2022
Scientific Reports

Volume: 12, P: 1-12

Search

Engineering bi-directional chemically-modulated synthetic condensates for cellular control

Widespread ilmenite contributions to the surface water cycle in lunar Procellarum KREEP Terrane

Reprogramming the tumor microenvironment with c-MYC-based gene circuit platform to enhance specific cancer immunotherapy

Oriented graphene nanoribbons embedded in hexagonal boron nitride trenches

Remodelling autoactive NLRs for broad-spectrum immunity in plants

Neoadjuvant gemcitabine–cisplatin plus tislelizumab in persons with resectable muscle-invasive bladder cancer: a multicenter, single-arm, phase 2 trial

Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth

Temporal shifts in 24 notifiable infectious diseases in China before and during the COVID-19 pandemic

The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming

ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency

Microenvironment reconstitution of highly active Ni single atoms on oxygen-incorporated Mo₂C for water splitting

A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis

Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair

A Transformer-LSTM-SVR hybrid model for AI-driven emotional optimization in NEV embedded interior systems

Directing curli polymerization with DNA origami nucleators

Room-temperature low-threshold avalanche effect in stepwise van-der-Waals homojunction photodiodes

LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment

Pristine PN junction toward atomic layer devices

Author Correction: A deep-learning pipeline for the diagnosis and discrimination of viral, non-viral and COVID-19 pneumonia from chest X-ray images

Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal

Precisely aligned graphene grown on hexagonal boron nitride by catalyst free chemical vapor deposition

Programmable and printable Bacillus subtilis biofilms as engineered living materials

Decoding of polar-coded OFDM systems over multipath fading channels with interleaving and channel state information

Structural insights into ligand recognition and activation of human purinergic receptor P2Y14

Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2

The epigenetic state of the cell of origin defines mechanisms of leukemogenesis

Experimental investigation of seismic performance of precast concrete shear walls with overlapping U-bar loop connections

Tumor-associated neutrophils suppress CD8⁺ T cell immunity in urothelial bladder carcinoma through the COX-2/PGE2/IDO1 Axis

The tumour-associated stroma correlates with poor clinical outcomes and immunoevasive contexture in patients with upper tract urothelial carcinoma: results from a multicenter real-world study (TSU-01 Study)

Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1

Photonic slide rule with metasurfaces

Configurable circular-polarization-dependent optoelectronic silent state for ultrahigh light ellipticity discrimination

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer

Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3

Effect of dissolved humic acids and coated humic acids on tetracycline adsorption by K₂CO₃-activated magnetic biochar

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