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Up-recycling waste wood as a source for producing materials is crucial for sustainability. Here, the authors discover that in situ thermal curing of melamine formaldehyde resin with natural wood enhanced its room temperature phosphorescence performance.

CRISPR-based diagnostics are often limited by complex workflows and poor validation. Here the authors develop and validate a one-pot asymmetric CRISPR assay, which permits rapid and sensitive diagnosis of tuberculosis in a format which is suitable for resource-limited settings.

Artificial cilia array devices are developed for sound frequency decoding and executing tasks such as drug release.

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins.

Fan et al. describe DF-003, an alpha-kinase 1 (ALPK1) inhibitor that targets the root cause of the rare genetic disease ROSAH syndrome, demonstrating the ability of DF-003 to inhibit ocular inflammatory pathology in ROSAH model mice.

Going from model development to a pilot implementation study, a deep learning model shows that acute aortic syndrome can be diagnosed directly from noncontrast CT, increasing accuracy and decreasing time to diagnosis.

Preparing room temperature phosphorescent materials from biomass is important but challenging. Here, the authors report the use of liquid monomer 2-hydroxyethyl acrylate for dissolution of lignin and subsequent solvent-free preparation of lignin-based RTP materials.

Hydrogels with room temperature phosphorescence have potential in a number of applications, but mechanical properties can limit the potential. Here, the authors report a wood-based hydrogel with room temperature phosphorescence, by polymerization of acrylamide with delignified wood.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Convenient and sustainable photoactivated room temperature phosphorescent (RTP) materials exhibit great potential in a wide ranging of applications but are difficult to obtain. Here the authors develop a photoactivated RTP materials by covalently attaching lignin to polylactic acid.

As presented at the 2025 AACR Annual Meeting, in an ongoing first-in-human phase 1 trial of a next-generation KRAS-G12C inhibitor in patients with solid tumors, encouraging safety and response results were observed, including in patients with non-small-cell lung cancer.

It is elusive to manufacture room temperature phosphorescent (RTP) materials through effective and ambient processing approaches. Here the authors report the production of photocured RTP materials using lignosulfonate to act as RTP chromophore and photoinitiator, achieving easy preparation, low cost and good performance.

Cross-phase manipulation holds potential for applications in synthetic biology and drug delivery. Here, authors present an acoustofluidic platform that enables rapid embedding of microparticles from an oil phase into aqueous droplets, offering an effective tool for studying cellular multiphase interactions and related phenomena.

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Neurodegenerative diseases are linked to changes in the immune system and inflammation. Here, the authors studied immune cells from healthy individuals and neurodegenerative diseases and identified sex-specific disease-associated changes.

Heo, Xu et al. used comprehensive plasma proteomics to identify 416 plasma proteins (294 new) associated with Alzheimer’s disease and applied machine learning to select 7 proteins that were highly predictive of Alzheimer’s disease across multiple cohorts.

Sustainable afterglow room temperature phosphorescence (RTP) Structural materials are difficult to achieve. Here, the authors demonstrate a wood based RTP material by oxidation of lignin to realize an afterglow RTP material with a lifetime of ~ 408 ms.

The authors present a valley-Hall topological acoustofluidic chip revealing the complex interactions between elastic valley spin and nonlinear fluid dynamics, revealing its potential towards on-chip biological applications.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

The purification of ethylene is an industrially relevant process. Here, the authors report the one-step separation of ethylene from quaternary gas mixtures of hydrocarbons and CO₂ using a single metal–organic framework-based physisorbent.

The ratio between the levels of two synaptic proteins in cerebrospinal fluid predicts future cognitive resilience versus decline among presymptomatic individuals and individuals with early Alzheimer’s disease harboring amyloid and tau pathology.

Non-pharmaceutical interventions for COVID-19 control impacted transmission of other pathogens including respiratory syncytial virus (RSV). Here, the authors perform phylodynamic analyses of RSV genomes from New Zealand to explore dynamics before, during, and after the COVID-19 pandemic.

A detailed understanding of the response of graphene resonators to changes in mass and temperature could lead to the development of ultrasensitive mass detectors and other nanoelectromechanical systems.

NME3 is a member of NDPK family. Here, Chen et. al., discover that histidine phosphorylatable NME3 is required for hypoxia-induced mitophagy via PA-dependent interaction with Drp1, which is protected from MUL1-mediated ubiquitination for mitophagy.

Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (dys)function and create a pathogenicity-severity variant classifier.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

The joint subarray acoustic tweezer platform offers 3D translation and rotation of bioparticles, enabling complex manipulation and cell deformation, with applications in tissue engineering, disease diagnostics, and drug testing.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Transancestral GWAS meta-analysis in 160,420 individuals identifies 139 loci associated with refractive error, including myopia. Newly identified genes implicate pathways involved in eye growth and light signaling cascades.

Mutations of CCR5 have been linked to improved outcome to HIV infection. Here the authors use CRISPR-Cas9 genome editing of CCR5 in mobilized hematopoietic stem progenitor cells and show protection in a murine xenograft HIV infection model.

BRCA2 has essential roles in suppressing genome instability at stalled replication forks, but how this is achieved remains unclear. Here, the authors apply Okazaki-fragment sequencing to predict sites of genomic instability caused by head-on transcription-replication conflicts upon BRCA2 loss.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Acoustic tweezers use ultrasound waves for non-contact manipulation of particles and cells, offering high biocompatibility and safe handling of samples. Their various configurations enhance functionality across scales, granting a great versatility, whereas addressing current reproducibility and technological limitations will promote wider applications in biomedical fields and precision medicine.

A publicly accessible tool—the TIMES score—for predicting the risk of recurrence of hepatocellular carcinoma is revealed, providing mechanistic insights into the prognostic patterns for hepatocellular carcinoma.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

TMEPro profiles the glycosylated secreted and plasma membrane proteome of 100 human pancreatic tissue samples, defines cell type origins and identifies potential paracrine cross-talk mediated through tyrosine phosphorylation.

An analysis of mice carrying the protein tau — a hallmark of Alzheimer’s disease — reveals that immune cells collaborate to drive tau-mediated neurodegeneration, and that drugs already in use in the clinic can combat this decline.

Countless biomedical discoveries have been made possible thanks to the hard work of graduate students. But students in China lack the same breadth of externally funded scholarship programs as their counterparts have in the West. If the Chinese government wants to strengthen its recruitment of elite graduate students from around the globe, it should expand the scholarship programs it offers.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

C₂H₄ is one of the most important chemical raw materials. Here, the authors report that tuning of pore structure shifts the multi-component gas separation function, enabling one-step production of high-purity C₂H₄ in the quaternary mixture.