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Showing 1–50 of 69 results

Advanced filters: Author: Wei-wei Wu Clear advanced filters

Realizing the practical application of CO₂ electroreduction for urban wastewater denitrification

An approach that integrates electrochemical CO₂ reduction and biological denitrification provides a new solution for nitrogen removal, where the formate obtained from CO₂ is used directly as the carbon source in the denitrification process in wastewater treatment.

Qiqi Wu
Sijia Ji
Guangxu Chen
Research29 Sept 2025
Nature Water

P: 1-12
Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways

Miao Yu
Zhi-xiao Fang
Ying-li Wu
Research21 Jul 2020
Acta Pharmacologica Sinica

Volume: 42, P: 604-612
Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro

Bo Jing
Meng Liu
Ying-li Wu
Research23 Nov 2017
Acta Pharmacologica Sinica

Volume: 39, P: 492-498
Ni-catalyzed benzylic β-C(sp³)–H bond activation of formamides

The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.

Rong-Hua Wang
Wei-Wei Xu
Mengchun Ye
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-9
Tunning valence state of cobalt centers in Cu/Co-CoO_1-x for significantly boosting water-gas shift reaction

Constructing catalysts with dual active sites is crucial for optimizing adsorption sites and enhancing catalytic performance. Here, uniformly dispersed CuCo alloy and CoO nanosheet composite catalysts with dual active sites were developed, significantly boosting activity in the water-gas shift reaction.

Xing-Chi Li
Jun-Hao Wang
Ya-Wen Zhang
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma

Antitumour immune responses to checkpoint blockade can be augmented by modulating the microbiota in the tumour with hydrogel-embedded silver nanoparticles and specific exogenous bacteria, as shown for mice with squamous carcinoma tumours.

Di-Wei Zheng
Wei-Wei Deng
Xian-Zheng Zhang
Research08 Nov 2021
Nature Biomedical Engineering

Volume: 6, P: 32-43
Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration

Undesired chromosomal translocations, vector integrations, and large deletions remain a problem for therapeutic gene editing in vivo. Here, the authors compare the CRISPR-Cas9TX variant with CRISPR-Cas9 and show elimination of chromosomal translocations and reduction of AVV integration when targeting Vegfa for the treatment of age-related macular degeneration in a mouse model.

Jianhang Yin
Kailun Fang
Jiazhi Hu
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-8
Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells

Wen-juan Liu
Hai-tang Wang
Jie Liu
Research01 Jun 2008
Acta Pharmacologica Sinica

Volume: 29, P: 653-660
Age-related changes of serum tartrate-resistant acid phosphatase 5b and the relationship with bone mineral density in Chinese women

Yue-juan Qin
Zhen-lin Zhang
Jin-wei He
Research01 Dec 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1493-1498
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia

Resistance to tyrosine kinase inhibitors (TKI) is a limitation to their use in treating chronic myelogenous leukemia (CML). Here, the authors show that targeting the ubiquitin peptidase USP47 overcomes TKI resistance and eliminates leukaemia stem/progenitor cells in primary and xenograft CML murine models.

Hu Lei
Han-Zhang Xu
Ying-Li Wu
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Discovery of oscillations above 200 keV in a black hole X-ray binary with Insight-HXMT

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Xiang Ma
Lian Tao
Ren-Lin Zhuang
Research21 Sept 2020
Nature Astronomy

Volume: 5, P: 94-102
Unraveling the energy storage mechanism in graphene-based nonaqueous electrochemical capacitors by gap-enhanced Raman spectroscopy

Graphene is widely used as an electrode material but the understanding of its interface with electrolyte remains elusive. Here, authors employ gap-enhanced Raman spectroscopy and find that the charging mechanism shifts from co-ion desorption to ion exchange as the number of graphene layers increase.

Xiao-Ting Yin
En-Ming You
Jia-Wei Yan
ResearchOpen Access04 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Boosting reactivity of water-gas shift reaction by synergistic function over CeO_2-x/CoO_1-x/Co dual interfacial structures

Rational engineering of interfacial structure is of great interest but it is challenging to construct active dual interfaces. Here, the authors report a strategy to establish stable dual active-interfaces resorting to the boosted oxygen spillover from ceria islets, showing high activity toward the water-gas shift reaction.

Xin-Pu Fu
Cui-Ping Wu
Chun-Jiang Jia
ResearchOpen Access27 Oct 2023
Nature Communications

Volume: 14, P: 1-11
The threats of micro- and nanoplastics to aquatic ecosystems and water health

Micro- and nanoplastics indirectly threaten water quality by disrupting biogeochemical cycles, transporting pathogens and interacting with emerging contaminants. This Review highlights their complex environmental roles and outlines regulatory and technological strategies to mitigate their impacts on aquatic ecosystems and water health.

Xuran Liu
Wei Wei
Bing-Jie Ni
Reviews11 Jul 2025
Nature Water

Volume: 3, P: 764-781
Designable ultra-smooth ultra-thin solid-electrolyte interphases of three alkali metal anodes

The dendrite growth of alkali metal anodes leads to charge/discharge cycling instability. Here, the authors show that electrochemical polishing can yield near-perfect anodes of three alkali metals by constructing smooth and thin solid-electrolyte interphase layers.

Yu Gu
Wei-Wei Wang
Bing-Wei Mao
ResearchOpen Access09 Apr 2018
Nature Communications

Volume: 9, P: 1-9
Resolving nanostructure and chemistry of solid-electrolyte interphase on lithium anodes by depth-sensitive plasmon-enhanced Raman spectroscopy

The solid-electrolyte interphase is crucial for most batteries, but its characterization is challenging. Here, authors develop a depth-sensitive plasmon-enhanced Raman spectroscopy method to enable in-situ and nondestructive resolving of its structure and chemistry as well as formation mechanisms.

Yu Gu
En-Ming You
Bing-Wei Mao
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-11
Partially sintered copper‒ceria as excellent catalyst for the high-temperature reverse water gas shift reaction

Constructing stable active sites in catalysts for high temperature catalytic reactions remains challenging. Here, the authors manage to make stable copper clusters in the copper‒ceria catalyst with high Cu loading (15 wt.%) for the high-temperature reverse water gas shift reaction.

Hao-Xin Liu
Shan-Qing Li
Chun-Jiang Jia
ResearchOpen Access14 Feb 2022
Nature Communications

Volume: 13, P: 1-11
Tracking the engraftment and regenerative capabilities of transplanted lung stem cells using fluorescent nanodiamonds

Fluorescent nanodiamonds can be used to tag implanted lung stem cells and follow their uptake and regeneration in host tissue.

Tsai-Jung Wu
Yan-Kai Tzeng
John Yu
Research04 Aug 2013
Nature Nanotechnology

Volume: 8, P: 682-689
TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease

TDP-43 inclusions are observed in Alzheimer’s disease. Here the authors show that TDP-43 interacts with amyloid-β and inhibits fibrillization in vitro and exacerbates Alzheimer’s disease pathology in animal models.

Yao-Hsiang Shih
Ling-Hsien Tu
Yun-Ru Chen
ResearchOpen Access23 Nov 2020
Nature Communications

Volume: 11, P: 1-17
p53 expression overcomes p21^WAF1/CIP1-mediated G₁ arrest and induces apoptosis in human cancer cells

Shunsuke Kagawa
Toshiyoshi Fujiwara
Noriaki Tanaka
Research16 Oct 1997
Oncogene

Volume: 15, P: 1903-1909
Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion

Yan Chen
Chen-yao Wang
Jing-gen Liu
Research20 Sept 2022
Acta Pharmacologica Sinica

Volume: 44, P: 538-545
Cancer risk among patients with type 2 diabetes mellitus: a population-based prospective study in China

Meng Wang
Ru-Ying Hu
Min Yu
ResearchOpen Access17 Jun 2015
Scientific Reports

Volume: 5, P: 1-7
In-vivo absorption of pinocembrin-7-O-β-D-glucoside in rats and its in-vitro biotransformation

Wei-Wei Guo
Feng Qiu
Xia Wu
ResearchOpen Access05 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
KRAS mutation and primary tumor location do not affect efficacy of bevacizumab-containing chemotherapy in stagae IV colorectal cancer patients

De-cong Sun
Yan Shi
Guang-hai Dai
ResearchOpen Access30 Oct 2017
Scientific Reports

Volume: 7, P: 1-8
Controlling Dispersion Characteristics of Terahertz Metasurface

Shi-Wei Qu
Wei-Wei Wu
Chi Hou Chan
ResearchOpen Access23 Mar 2015
Scientific Reports

Volume: 5, P: 1-6
Graphene based All-Optical Spatial Terahertz Modulator

Qi-Ye Wen
Wei Tian
Huai-Wu Zhang
ResearchOpen Access10 Dec 2014
Scientific Reports

Volume: 4, P: 1-5
Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats

Li-sha Xu
Li-xia Yang
Zhong Chen
Research01 Dec 2005
Acta Pharmacologica Sinica

Volume: 26, P: 1448-1453
Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif

Ye Luo
Yu Hao
Na Li
Research01 May 2008
Acta Pharmacologica Sinica

Volume: 29, P: 628-633
Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion

Jing Ma
Jing Zhang
Wei Wei Hu
ResearchOpen Access15 Jul 2015
Scientific Reports

Volume: 5, P: 1-14
Effects of maize rotation on the physicochemical properties and microbial communities of American ginseng cultivated soil

Xiao-Lin Jiao
Xue-Song Zhang
Wei-Wei Gao
ResearchOpen Access13 Jun 2019
Scientific Reports

Volume: 9, P: 1-12
Elevated Type II Secretory Phospholipase A2 Increases the Risk of Early Atherosclerosis in Patients with Newly Diagnosed Metabolic Syndrome

Chang-Qing Sun
Chun-Yan Zhong
Zhi-Yuan Song
ResearchOpen Access12 Dec 2016
Scientific Reports

Volume: 6, P: 1-8
Implantation of bFGF-treated islet progenitor cells ameliorates streptozotocin-induced diabetes in rats

Ge Li
Li-song Huang
Da-ru Lu
Research18 Oct 2010
Acta Pharmacologica Sinica

Volume: 31, P: 1454-1463
Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring

Hua Yue
Jin-wei He
Zhen-lin Zhang
Research19 Mar 2012
Acta Pharmacologica Sinica

Volume: 33, P: 660-667
A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities

Min He
Ni Guan
Ming-wei Wang
Reviews03 Feb 2012
Acta Pharmacologica Sinica

Volume: 33, P: 148-154
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response

Qian-hui Zhang
Lei-ming Jin
Guang Liang
Research27 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1946-1957
Reversal of hyperglycemia by protein transduction of NeuroD in vivo

Yin Huang
Jing Chen
Da-ru Lu
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1181-1188
Association between SNP and haplotypes in PPARGC1 and adiponectin genes and bone mineral density in Chinese nuclear families

Zhen-lin Zhang
Jin-wei He
Wei-wei Hu
Research01 Feb 2007
Acta Pharmacologica Sinica

Volume: 28, P: 287-295
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury

Hai-lei Ding
Hai-feng Zhu
Zhao-nian Zhou
Research01 Mar 2005
Acta Pharmacologica Sinica

Volume: 26, P: 315-322
Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis

Xue-Jun Zhang, Jun Wang and colleagues identify mutations in MVK in disseminated superficial actinic porokeratosis, a disorder characterized by defects in epidermal keratinization. MVK encodes mevalonate kinase, an enzyme involved in the biosynthesis of cholesterol and isoprenoids.

Sheng-Quan Zhang
Tao Jiang
Xue-Jun Zhang
Research16 Sept 2012
Nature Genetics

Volume: 44, P: 1156-1160
Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis

Yuan-qiang Wang
Wei-wei Lin
Zhi-wei Feng
Research27 Feb 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1138-1156
Proximal Tubular Epithelial Cell Integrins Respond to High Glucose by Altered Cell-Matrix Interactions and Differentially Regulate Matrixin Expression

Panagiotis M Karamessinis
Athina K Tzinia
Effie C Tsilibary
Research01 Aug 2002
Laboratory Investigation

Volume: 82, P: 1081-1093
Structural analogues in herbal medicine ginseng hit a shared target to achieve cumulative bioactivity

Zhang et al. design ginsenoside structural analogues and demonstrate that their combination shows more potent immunomodulatory activities than individual ginsenosides used alone at the same dosages. They predict that these analogues act on the joint target NLRP3 and consequently suggest that structural analogues hit a shared target to achieve cumulative bioactivity.

Wei Zhang
Wei-Wei Tao
Qi-Nan Wu
ResearchOpen Access10 May 2021
Communications Biology

Volume: 4, P: 1-14
A function-based mapping of sensory integration along the cortical hierarchy

A two-dimensional framework representing integrative sensory information along a hierarchy from unimodal to transmodal regions distinguishes between brain states and highlights how sensory integration adapts flexibly to varying cognitive demands.

Wei Wei
R. Austin Benn
Daniel S. Margulies
ResearchOpen Access29 Nov 2024
Communications Biology

Volume: 7, P: 1-14
Study the local metabolic changes of aneurysms through microcatheter sampling

Zejin Li
Tingbao Zhang
Wenyuan Zhao
ResearchOpen Access22 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2

Liang Wu
Wen-yan Song
Ying-pu Sun
ResearchOpen Access16 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-14
Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury

Xiao-li Wu
Shou-sheng Lu
Xiang-nan Zhang
Research27 Feb 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1016-1024
Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity

Yu Wang
Xi Xiang
Jian-Qing He
ResearchOpen Access18 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response

Chen Li
Lu Feng
Hong-Bing Shu
ResearchOpen Access22 Jun 2021
Cell Discovery

Volume: 7, P: 1-12
Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury

Min He
Ni Cheng
Ming-wei Wang
Research18 Apr 2011
Acta Pharmacologica Sinica

Volume: 32, P: 601-610
Broadband diffusion of terahertz waves by multi-bit coding metasurfaces

Li-Hua Gao
Qiang Cheng
Tie-Jun Cui
ResearchOpen Access11 Sept 2015
Light: Science & Applications

Volume: 4, P: e324

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