Nature Search

Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence

Hou, Chen et al. show that aged bone marrow macrophages propagate senescence to multiple tissues in vivo, through extracellular vesicles containing PPARα-targeted microRNAs. They demonstrate the therapeutic potential of intervening in this process using the PPARα agonist fenofibrate.

Jing Hou
Kai-Xuan Chen
Chang-Jun Li
ResearchOpen Access12 Sept 2024
Nature Aging

Volume: 4, P: 1562-1581
Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Min-fang Tao
Zeng Zhang
Zhen-lin Zhang
Research17 Jun 2013
Acta Pharmacologica Sinica

Volume: 34, P: 1070-1074
Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women

Wei-wei Hu
Yao-hua Ke
Zhen-lin Zhang
Research20 Oct 2014
Acta Pharmacologica Sinica

Volume: 35, P: 1521-1526
No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families

Jin-bo Yu
Yao-hua Ke
Zhen-lin Zhang
Research18 Oct 2010
Acta Pharmacologica Sinica

Volume: 31, P: 1464-1469
Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males

Hua Yue
Jin-wei He
Zhen-lin Zhang
Research25 Mar 2013
Acta Pharmacologica Sinica

Volume: 34, P: 710-716
Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring

Yao-hua Ke
Wen-jin Xiao
Zhen-lin Zhang
Research03 Feb 2012
Acta Pharmacologica Sinica

Volume: 33, P: 201-207
The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data

Jie-mei Gu
Li Wang
Zhen-lin Zhang
Research08 Jun 2015
Acta Pharmacologica Sinica

Volume: 36, P: 841-846
Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families

Hao Zhang
Jin-wei He
Zhen-lin Zhang
Research05 Aug 2010
Acta Pharmacologica Sinica

Volume: 31, P: 977-983
Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families

Jie-mei Gu
Wen-jin Xiao
Zhen-lin Zhang
Research04 Dec 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1634-1642
BMP7 gene polymorphisms are not associated with bone mineral density or osteoporotic fractures in postmenopausal Chinese women

Li-hong Gao
Shan-shan Li
Zhen-lin Zhang
Research06 Jun 2016
Acta Pharmacologica Sinica

Volume: 37, P: 1076-1082
No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women

Wei-wei Hu
Jin-wei He
Zhen-lin Zhang
Research23 May 2011
Acta Pharmacologica Sinica

Volume: 32, P: 947-955
Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring

Hua Yue
Jin-wei He
Zhen-lin Zhang
Research19 Mar 2012
Acta Pharmacologica Sinica

Volume: 33, P: 660-667
Calcification of joints and arteries: second report with novel NT5E mutations and expansion of the phenotype

Zeng Zhang
Jin-Wei He
Zhen-Lin Zhang
Research16 Jul 2015
Journal of Human Genetics

Volume: 60, P: 561-564
Retraction Note: LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma

Quan Hong
Ou Li
Xiang-mei Chen
Amendments and CorrectionsOpen Access01 Oct 2024
Cell Death & Disease

Volume: 15, P: 1
Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Huijie Bian
Zhao-Hui Zheng
Ping Zhu
ResearchOpen Access17 May 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-11
miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing

Wen-Zhen He
Mi Yang
Chang-Jun Li
ResearchOpen Access25 May 2022
Cell Death & Disease

Volume: 13, P: 1-13
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

Nan-Yu Zou
Ran Liu
Chang-Jun Li
ResearchOpen Access25 Jan 2024
Bone Research

Volume: 12, P: 1-15
Novel mutations of TCIRG1 cause a malignant and mild phenotype of autosomal recessive osteopetrosis (ARO) in four Chinese families

Xiao-ya Zhang
Jin-wei He
Zhen-lin Zhang
Research17 Aug 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1456-1465
Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women

Chong Shao
Yi-wen Wang
Zhen-lin Zhang
Research05 Mar 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1212-1218
Genetically Low Vitamin D Levels, Bone Mineral Density, and Bone Metabolism Markers: a Mendelian Randomisation Study

Shan-Shan Li
Li-Hong Gao
Zhen-Lin Zhang
ResearchOpen Access14 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
RETRACTED ARTICLE: LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma

Quan Hong
Ou Li
Xiang-mei Chen
ResearchOpen Access11 May 2017
Cell Death & Disease

Volume: 8, P: e2772

Search

Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence

Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population

Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women

No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families

Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males

Association of ALOX15 gene polymorphisms with obesity-related phenotypes in Chinese nuclear families with male offspring

The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data

Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families

Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families

BMP7 gene polymorphisms are not associated with bone mineral density or osteoporotic fractures in postmenopausal Chinese women

No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women

Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring

Calcification of joints and arteries: second report with novel NT5E mutations and expansion of the phenotype

Retraction Note: LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing

Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing

Novel mutations of TCIRG1 cause a malignant and mild phenotype of autosomal recessive osteopetrosis (ARO) in four Chinese families

Genetic variants in the PLS3 gene are associated with osteoporotic fractures in postmenopausal Chinese women

Genetically Low Vitamin D Levels, Bone Mineral Density, and Bone Metabolism Markers: a Mendelian Randomisation Study

RETRACTED ARTICLE: LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma

Search

Quick links

Search

Filter By:

Search

Quick links