Nature Search

Ginger genome reveals the SMPED1 gene causing sex-phase synchrony and outcrossing in a flowering plant

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Jian-Li Zhao
Yang Dong
Qing-Jun Li
Research07 Oct 2025
Nature Plants

P: 1-14
Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells

Wen-jing Xiao
Ting Ma
Guang-ji Wang
Research26 Jan 2015
Acta Pharmacologica Sinica

Volume: 36, P: 259-267
Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

Inverse electron-demand cycloadditions in palladium catalysis are inherently limited by the linear selectivity in the allylic substitution step. To overcome this issue, the authors report a synergetic iridium (branched-selective) and amine catalysis in [4+2] cycloadditions of vinyl aminoalcohols with carbonyls.

Mao-Mao Zhang
Ya-Ni Wang
Wen-Jing Xiao
ResearchOpen Access20 Jun 2019
Nature Communications

Volume: 10, P: 1-9
Enantioselective macrocyclization via catalytic metallic dipole relay

Despite the importance of chiral macrocycles, their synthesis has lagged behind those of normal and medium-sized rings. Now a bio-inspired catalytic metallic dipole relay strategy enables access to the synthesis of axially chiral 14-, 15- and 20-membered macrocyclic products.

Bao-Le Qu
Meng Xiao
Liang-Qiu Lu
Research04 Apr 2025
Nature Catalysis

Volume: 8, P: 368-377
Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway

Wen-jing Cui
Yi Liu
Li-hong Ye
Research10 May 2010
Acta Pharmacologica Sinica

Volume: 31, P: 725-732
Construction of planar chiral [2,2]paracyclophanes via photoinduced cobalt-catalyzed desymmetric addition

Planar chiral [2,2]paracyclophanes (PCPs) are widely used in materials science and asymmetric syntheses. Here the authors present a cobalt-catalyzed desymmetric addition of pseudopara-diformyl and pseudo-gem-diformyl PCPs, enabling the synthesis of planar chiral PCP alcohols with both planar and central chiralities.

Shi-Qi Liu
Wei Xiong
Wen-Jing Xiao
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo

Jian Shi
Bei Cao
Chang-xiao Liu
Research29 Jul 2013
Acta Pharmacologica Sinica

Volume: 34, P: 1349-1358
Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Amendments and Corrections01 Sept 2014
Nature Genetics

Volume: 46, P: 1041
Catalytic N-radical cascade reaction of hydrazones by oxidative deprotonation electron transfer and TEMPO mediation

The use of N-centred radicals is limited by the difficulties in their preparation. Here, the authors report a photoredox method for the formation of N-centred radicals on hydrazones and their use for the synthesis of heterocyclic compounds through a radical cascade reaction.

Xiao-Qiang Hu
Xiaotian Qi
Wen-Jing Xiao
ResearchOpen Access06 Apr 2016
Nature Communications

Volume: 7, P: 1-12
Impact of ABO incompatibility on outcomes after haploidentical hematopoietic stem cell transplantation for severe aplastic anemia

Yan-Ru Ma
Wen-Jing Wang
Lan-Ping Xu
Research13 Jan 2020
Bone Marrow Transplantation

Volume: 55, P: 1068-1075
Asymmetric three-component olefin dicarbofunctionalization enabled by photoredox and copper dual catalysis

Vicinal dicarbofunctionalization (DCF) reactions of alkenes have been extensively explored in ionic chemistry but the enantioselective radical mediated version of DCF remains largely unexplored. Here, the authors demonstrate a radical vicinal DCF reaction of olefins by merging of radical addition and cross-coupling using photoredox and copper dual catalysis.

Peng-Zi Wang
Yuan Gao
Jia-Rong Chen
ResearchOpen Access22 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Constructing regulable supports via non-stoichiometric engineering to stabilize ruthenium nanoparticles for enhanced pH-universal water splitting

Establishing optimal metal-support interactions is crucial for creating efficient catalysts for water splitting. Here, stable Ti–O–Ru interface formation and minimal work function difference between Ru nanoparticles and non-stoichiometric Ti4O7 lead to exceptional bifunctional activity of Ru/Ti4O7 for both HER and OER across pH-universal environments, maintaining stable operation for 500 h.

Sheng Zhao
Sung-Fu Hung
Shengjie Peng
ResearchOpen Access29 Mar 2024
Nature Communications

Volume: 15, P: 1-12
Galangin, a novel Kv7 potassium channel opener, exerts potent antinociceptive effects in multiple chronic pain mouse models

Bo Yang
Hui Liu
Fan Zhang
Research07 Aug 2025
Acta Pharmacologica Sinica

P: 1-12
FG020326-loaded nanoparticle with PEG and PDLLA improved pharmacodynamics of reversing multidrug resistance in vitro and in vivo

Wen-jing Deng
Xiao-qiang Yang
Li-wu Fu
Research01 Jun 2007
Acta Pharmacologica Sinica

Volume: 28, P: 913-920
Immunological and inflammatory profiles in mild and severe cases of COVID-19

Immunophenotyping of patients with COVID-19 is ongoing, but much remains to be learned. Here the authors analyze 41 hospitalized patients with COVID-19 and show a higher degree of lymphopenia in various immune cell subsets as well as cytotoxicity and T cell inhibitory marker expression in severe cases compared with mild.

Jin-Wen Song
Chao Zhang
Ji-Yuan Zhang
ResearchOpen Access08 Jul 2020
Nature Communications

Volume: 11, P: 1-10
Asymmetric trapping of zwitterionic intermediates by sulphur ylides in a palladium-catalysed decarboxylation-cycloaddition sequence

Sulphur ylides are useful reagents in organic synthesis, typically reacting with highly polar reagents. Here, the authors show a catalytic asymmetric process for the addition of sulphur ylides to cyclic allylic esters with loss of CO₂, giving access to chiral, highly functionalised indolines.

Tian-Ren Li
Fen Tan
Wen-Jing Xiao
Research21 Nov 2014
Nature Communications

Volume: 5, P: 1-10
Construction of axial chirality via asymmetric radical trapping by cobalt under visible light

Controlling the enantioselectivity in metallaphotoredox-catalysed radical cross-couplings using cobalt has proven challenging. Now, the identification of a chiral polydentate ligand enables cobalt-catalysed enantioselective couplings with a broad scope of radicals affording chiral heterobiaryl products.

Xuan Jiang
Wei Xiong
Wen-Jing Xiao
Research15 Sept 2022
Nature Catalysis

Volume: 5, P: 788-797
Novel polymer micelle mediated co-delivery of doxorubicin and P-glycoprotein siRNA for reversal of multidrug resistance and synergistic tumor therapy

Chun-ge Zhang
Wen-jing Zhu
Xue-nong Zhang
ResearchOpen Access31 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
Optical simulation of a Popescu-Rohrlich Box

Wen-Jing Chu
Xiao-Lan Zong
Zhuo-Liang Cao
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Characterizing the immune landscape of tumor-infiltrating lymphocytes in non-small cell lung cancer

Jin-Guo Liu
Lin Yu
Yue Li
Research05 May 2025
Genes & Immunity

Volume: 26, P: 229-241
Predicting the severity of mycoplasma pneumoniae pneumonia in pediatric and adult patients: a multicenter study

Li-Yong Zhuo
Jia-Wei Hao
Xiao-Ping Yin
ResearchOpen Access03 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Light-empowered contra-thermodynamic stereochemical editing

Stereochemical editing is a strategy to access three-dimensional skeletons, where the stereochemistry-defining steps are decoupled from the major connectivity-forming reactions. This Review highlights recent advances in the area of light-driven contra-thermodynamic stereochemical editing.

Peng-Zi Wang
Wen-Jing Xiao
Jia-Rong Chen
Reviews16 Nov 2022
Nature Reviews Chemistry

Volume: 7, P: 35-50
CDK14 regulates the development and repair of lung

Jian-wei Chen
Yu-xiang Wang
Qi Chen
ResearchOpen Access18 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-14
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Research22 Aug 2010
Nature Genetics

Volume: 42, P: 759-763
An improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion

Fei Hu
Chang-Sheng Huang
Tang-Fu Xiao
ResearchOpen Access01 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice

Xin Chen
Jie Liu
Xiao-hui Li
Research24 Sept 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1416-1426
Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

Xiao Guan
Guo-rong Dan
Xiao-hui Li
Research30 Sept 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1419-1429
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice

Luo-xing Xia
Ying-ying Xiao
Xi-yong Yu
Research08 Apr 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1644-1659
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Xiang-Ning Meng
Jin-Fa Ma
Song-Bin Fu
ResearchOpen Access09 Apr 2024
British Journal of Cancer

Volume: 130, P: 1819-1827
Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair

Xiu Sun
Zijian Tan
Zhida Su
ResearchOpen Access09 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-17
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Qing-zhang Tuo
Yu Liu
Peng Lei
ResearchOpen Access23 Feb 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-15
RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis

Qiu-Lin Ge
San-Hong Liu
Yin-Cheng Teng
ResearchOpen Access06 Oct 2016
Cell Death & Disease

Volume: 7, P: e2402
Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells

Tao Wang
Zhong-yi Qin
Bin Wang
Research19 Mar 2018
Cell Death & Differentiation

Volume: 25, P: 2086-2100
Low-level Gestational Lead Exposure Alters Dendritic Spine Plasticity in the Hippocampus and Reduces Learning and Memory in Rats

Zai-Hua Zhao
Gang Zheng
Jing-Yuan Chen
ResearchOpen Access23 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

Ji Feng
Pei-zhi Lu
Guo-dong Lu
Research15 Jun 2020
Acta Pharmacologica Sinica

Volume: 42, P: 160-170
Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection

Cai-Feng Chen
Xia Feng
You-Wen He
ResearchOpen Access15 Sept 2014
Scientific Reports

Volume: 4, P: 1-10
CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells

Rong Zhu
Chun-ge Zhang
Xue-nong Zhang
ResearchOpen Access07 Dec 2015
Scientific Reports

Volume: 5, P: 1-13
Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins

Yu Mei
Wen-Jing Jia
Hong-Wei Xue
Research06 Sept 2011
Cell Research

Volume: 22, P: 581-597
Author Correction: α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice

Xin Chen
Jie Liu
Xiao-hui Li
Amendments and Corrections16 Nov 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1875-1878
Metadherin facilitates podocyte apoptosis in diabetic nephropathy

Wen-Ting Liu
Fen-Fen Peng
Hai-Bo Long
ResearchOpen Access24 Nov 2016
Cell Death & Disease

Volume: 7, P: e2477
Adaptive evolution of rhizobial symbiotic compatibility mediated by co-evolved insertion sequences

Ran Zhao
Li Xue Liu
Chang Fu Tian
ResearchOpen Access11 Aug 2017
The ISME Journal

Volume: 12, P: 101-111
Targeting NAD+: is it a common strategy to delay heart aging?

Yang Yuan
Bing Liang
Dong-Ming Xing
ReviewsOpen Access26 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-14

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