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Dissolution of manganese from the cathode in lithium manganate based batteries is a major cause for the capacity decay. Here, the authors show a nanoscale surface-doping approach to mitigate the problem and to improve the battery capacity and cycleability.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Disorder may play a dominant role in determining the nonlinear Hall effect in a topological material. Here, Du et al. derive formulas of the nonlinear Hall conductivity and construct the general scaling law of the nonlinear Hall effect in a tilted two dimensional Dirac model.

The deformation mechanisms of twin boundaries in nanotwinned metallic materials are still unclear. Here the authors combine in situ transmission electron microscopy tensile tests and molecular dynamics simulations with a dislocation-based theoretical model to reveal the deformation mechanism of nanotwins.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Zeolites are porous aluminosilicate molecular sieves with uniform pores of molecular dimensions that have a wide range of applications. Here authors use machine learning to guide zeolite synthesis and predict the structure and properties of faujasite zeolites from synthesis conditions.

III–V semiconductors are promising platform for qubits, but strong coupling to lattice phonons enhances decoherence of qubit states that have a charge dipole. Here, the authors show that a microwave analogue to the Raman effect can lead to rapid dephasing of qubits based on GaAs double quantum dots.

The interaction between antiferromagnetic magnons and electrons sits at the heart of many strongly correlated systems, however, investigation has been hampered by a lack of clear-cut examples. Here, Yu et al directly observe a kink in the dispersion, a result of renormalization due to the electron-antiferromagnetic magnon interaction.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

The authors report that the metallic spin-1/2 chain compound Ti₄MnBi₂ forms near a quantum critical point with inherent frustration. They identify strong 1D spin and 3D electron coupling that should stimulate the search for materials exhibiting a 1D Kondo effect and heavy fermions.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Aqueous Zn-ion batteries are promising devices but their energy storage mechanism remains elusive. Now it is shown that these involve a catalytic mechanism based on water dissociation.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Cavitation bubbles show many nonlinear characteristics of liquid and gas phase. Here the authors demonstrate coherent diffractive imaging of cavitation bubble using infrared pump and XFEL probe and discuss the formation and evolution of the bubbles.

Shortening the inter-spin distance is an effective way to enhance magnetic coupling. However, it is typically challenging to change the inter-ion distance in most magnetic systems. Here, Huang et al present a strategy for enhancing magnetic interactions, by confining a molecular magnetic system inside a carbon fullerene cage, leading to enhanced magnetic properties.

Metal-fluoride-based lithium-ion battery cathodes are typically classified as conversion materials because reconstructive phase transitions are presumed to occur upon lithiation. Metal fluoride lithiation is now shown to be dominated instead by diffusion-controlled displacement mechanisms.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

To unlock the potential of Mn-based cathode materials, the fast capacity fading process has to be first understood. Here the authors utilize advanced characterization techniques to look at a spinel LiMn₂O₄ system, revealing that a combination of irreversible structural transformations and Mn dissolution takes responsibility.

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

The authors realize low-pressure-driven polarization switching in PbTiO₃ membranes by leveraging their structural tunability and substrate elasticity, enabling ferroelectric field-effect transistors on silicon, operatable mechanically and electrically.

Topological superconductors are potentially important for future quantum computation, but they are very rare in nature. Here, the authors observe topological surface states acquiring a nodeless superconducting gap with similar magnitude as that of the bulk states in 2M-WS₂, suggesting an intrinsic topological superconductor.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

Early intermittent feeding of mice with a high-cholesterol Western-type diet accelerates atherosclerosis compared with late continuous exposure to the Western-type diet, despite similar cumulative circulating LDL-C levels.

The joint analysis of datasets from NOvA and T2K, the two currently operating long-baseline neutrino oscillation experiments, provides new constraints related to neutrino masses and fundamental symmetries.

A micronuclear battery is built based on an autoluminescent americium–terbium compound that couples radioisotopes with energy transducers at the molecular level, resulting in an 8,000-fold enhancement in energy conversion efficiency.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

Reduction on cobalt reliance is an urgent requirement in the development of sustainable cathode materials for Li-ion batteries. Here the authors analyse the roles of cobalt and its interplay with other ions in high-nickel layered oxides, and deduce a material formula for promising cobalt-free cathodes.

The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcriptional pause release at AR-regulated genes.

Clamping effects in ferroelestastic thin films limits their usefulness for applications such as sensitive mechanical sensors. Here, the authors report on non-local mechanical force induced switching in PbTiO₃ thin films by tuning the material to a state of nearly energetically degenerate co-existing domains.

The MICrONS mouse visual cortex dataset shows that neurons with similar response properties preferentially connect, a pattern that emerges within and across brain areas and layers, and independently emerges in artificial neural networks where these ‘like-to-like’ connections prove important for task performance.

6R-TaS2 is a natural van der Waals heterostructure formed by 1H- and 1T-phase TaS₂ layers, which can individually exhibit Ising superconductivity, correlated states and charge density waves. Here, the authors show experimental evidence of emergent nematic Ising superconductivity with simultaneous hidden magnetism (extrinsic anomalous Hall effect and Kondo screening) in 6R-TaS₂ under 30 K.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

A vanadium-based lithium-rich disordered rock salt oxide is shown to work as a low-potential anode with rapid intercalation kinetics for lithium-ion batteries.

The first operation of the European X-ray free-electron laser facility accelerator based on superconducting technology is reported. The maximum electron energy is 17.5 GeV. A laser average power of 6 W is achieved at a photon energy of 9.3 keV.

Optimizing the synthesis for efficient luminescent materials requires consideration of a large number of parameters. Here, the authors realize high quantum yield full-color carbon quantum dot using an iterative machine-learning experimental strategy.

Neural Decomposition (NEURD) is a software package that decomposes neuronal data from high-resolution electron microscopy volumes into feature-rich graph representations to facilitate analysis for neuroscience research.

Time- and momentum-resolved spectroscopy gives dynamical information on complex materials, enabling disentanglement of their coupled degrees of freedom. Using time-resolved X-ray diffraction at a free electron laser, Leeet al. investigate the charge order parameter in a striped nickelate.

Olivine iron phosphate (FePO₄) is widely proposed for electrochemical lithium extraction, but particles with different physical attributes demonstrate varying Li preferences. Here, the authors characterize the electrochemical lithiation and sodiation behavior of a series of FePO₄ particles with different morphology to identify critical features that enhance Li selectivity.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Studying the nature of actinide-actinide bonds is important for understanding the electronic structure of the 5f elements, but the synthesis of these chemical bonds remains extremely challenging. Here, the authors report a strong covalent Th-Th bond formed between two rarely accessible Th³⁺ ions, stabilized inside a fullerene cage.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

ATP production by mitochondria requires the efficient flow of protons through the F₁F_O ATP-synthase complex. Jonas and colleagues show that Bcl-xL interacts with the F₁F_O complex in the mitochondrial matrix and increases the efficiency of this enzyme by decreasing proton leak.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Therapeutic administration of IL-27—serum levels of which are decreased in individuals with obesity—improves thermogenesis, protects against diet-induced obesity and ameliorates insulin resistance in mouse models of obesity.

Peptide-based therapeutics are promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. Here, the authors report the selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine chemistry, with decafluoro-diphenylsulfone.

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

This work shows that by designing appropriate alloying elements in a body-centred-cubic high-entropy alloy, local chemical order and lattice distortion can be tuned, which influences the evolution of planar-slip bands, realizing pure-metal-like tensile ductility at gigapascal yield strength.