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The authors report their observation of the fractional quantum anomalous Hall effect in rhombohedral hexalayer graphene/hBN moiré superlattice devices.

Keypoint-MoSeq is an unsupervised behavior segmentation algorithm that extracts behavioral modules from keypoint tracking data acquired with diverse algorithms, as demonstrated in mice, rats and fruit flies. The extracted modules faithfully reflect human-annotated behaviors even though they are obtained in an unsupervised fashion.

The clinical significance of inferring cell spatial profiles from histology images from cancer patients remains to be explored. Here, the authors develop a weakly-supervised deep-learning method, HistoCell, for the direct prediction of super-resolution cell spatial profiles from histology images at the single-nucleus-level.

Previously documented record values of the fusion triple product in the stellarator Wendelstein 7-X are shown to be evidence for reduced neoclassical energy transport in this optimized device.

DNA transactions promote torsional constraints that pose inherent risks to genome integrity. Here the authors identify the macro-histone splice variant macroH2A1.1 as an epigenetic modulator of topoisomerase 1-associated genome maintenance. MacroH2A1.1 expression determines sensitivity to TOP1 poisons and may present a cancer vulnerability.

Genomic profiling of tumours can help tailer treatments to the patient, however, it often fails to accurately predict therapeutic outcomes. Here, the authors combine molecular and functional characterisation via BH3 profiling to identify therapeutically targetable vulnerabilities in glioma.

The collective-flow-assisted nuclear shape-imaging method images the nuclear global shape by colliding them at ultrarelativistic speeds and analysing the collective response of outgoing debris.

Exploring low-cost, efficient catalysts to replace platinum is crucial for electrocatalytic hydrogen generation. Here, the authors report a termination-acidity strategy that boosts the activity of molybdenum carbides, achieving a low overpotential and sustaining hydrogen generation for over 200 h.

A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-peptide backbone. BEAR reactions represent a general strategy to install extended backbones into genetically encoded proteins and peptides expressed in cells.

Ultrashort electron bunches are promising for diffractive imaging measurements of structural dynamics, particularly in small or delicate structures. To this end, McCulloch et al. use a two-colour photoionization process to generate high-coherence ultrafast electron bunches from laser-cooled atoms.

Most of the notable properties of graphene are a result of the cone-like nature of the points in its electronic structure where its conduction and valance bands meet. Similar structures arise in 2D HgTe quantum wells, but without the spin- and valley-degeneracy of graphene; their properties are also likely to be easier to control.

The poor structural stability of cathode materials is responsible for the rapid capacity loss of sodium-ion batteries during cycling. This work addresses the instability by introducing vacancies into the transition metal layers and realize long-life pouch cells.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The authors observe X-ray coherent scattering speckles from substrate-supported planar patterns in grazing incidence reflection geometry, which constitutes hard X-ray holograms revealing three-dimensional high-resolution structural information in a single image.

Solution-grown perovskite heterojunctions and quantum wells bring new opportunities for exploring semiconductor physics in a convenient manner

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Multiple resonance (MR) emitters with narrowband luminescence typically suffer from inadequate frontier molecular orbital levels. Here, authors incorporate cyano motifs at peripheral sites of the MR backbone to adjust the energy levels, realizing device efficiency of over 23% for stable devices.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

A transformer-based representation-learning model that processes multimodal input in a unified manner outperformed non-unified multimodal models in two clinical diagnostic tasks.

Projective representations of crystal symmetries are indispensable for understanding artificial crystals. Here, authors establish a unified theory of projective crystal symmetries with time-reversal invariance, and construct models for all 458 projective symmetry algebras for the 17 two-dimensional wallpaper groups.

Wafer-scale 3R-MoS₂ with high phase purity is achieved through a homoepitaxy strategy, which demonstrates ferroelectricity and holds promise for multifunctional integration.

Stereoselective synthetic routes use P3HB (a polyester produced by bacteria) as a chiral feedstock for related polymers that have properties more amenable to processing and use.

SEAM is a platform for the analysis of high-resolution secondary ion mass spectrometry imaging that allows spatially resolved nuclear metabolomic profiling at the single-cell level.

Functional materials that act as bio-sensing media when interfaced with complex bio-matter are attractive for health sciences and bio-engineering. Here, the authors report room temperature enzyme-mediated spontaneous hydrogen transfer between a perovskite quantum material and glucose reactions.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

Oxide memristors exhibit noise in excess of 2–4 orders of magnitude above the baseline at quantized conductance states. Here, the authors measure anomalous electrical noise at these states in tantalum oxide memristors and relate it to thermally-activated atomic fluctuations by numerical simulations.

A proper theoretical description for unconventional superconductivity in iron-based compounds remains elusive. Here, the authors, to capture the electron correlation strength and the role of Fermi surfaces, report ARPES measurements of three iron chalcogenide superconductors to establish universal features.

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

The development of practical photonic quantum technologies will be aided by the spatial control of entangled photons. Lenget al. achieve on-chip spatial control of entangled photons by using domain engineering, rather than by using external optical elements.

Zhang, Mille-Fragoso and colleagues developed a synthetic receptor platform named LIDAR (Ligand-Induced Dimerization-Activating RNA editing), which enables ligand-responsive gene regulation without the need of DNA promoters and is, thus, compatible with mRNA delivery.

Without relying on any infrastructure-based vehicle detectors, the authors present a scalable traffic signal re-timing system that uses a small percentage of connected vehicle trajectories as the only input. Real-world tests demonstrate that the system decreases both delays and number of stops.

Deformation twinning, a key deformation mechanism that is rarely explored in superhard materials, is shown to be activated in cubic boron nitride and other cubic covalent materials under a loading-specific twinning criterion.

Lilies are perennial plants with ornamental flowers and large genomes. The authors assemble genomes of two Liliales species, analyze lily phylogeny, flower and stem development (bulbs in lilies, rhizomes in flame lilies), bulb growth transitions, and colchicine biosynthesis.

Sand fly vector control strategies are limited. Here, Cecilio et al. use the bacteria Delftia tsuruhatensis TC1 to reduce the ability of sand flies to become infected with Leishmania parasites and effectively transmit them to mammalian hosts.

In this Consensus Statement, a consortium of microbiome scientists discuss current sequencing data sharing policies and propose the use of a Data Reuse Information (DRI) tag to promote equitable and collaborative data sharing.

Weyl semimetals exhibit exotic properties owing to the presence of Weyl fermions. Here, Xu et al. show that tantalum phosphide is an ideal platform for studying the transport properties of these particles because its low-energy properties are dominated by a single type of Weyl fermion.

The authors identify feeblin, an inhibitory compound of the proinflammatory TLR7/8/9-IRF5 pathway with therapeutic potential, which acts by binding SLC15A4 via an allosteric mechanism mediating degradation of its signaling partner TASL.

Wide use of graphene nanosheets has raised concerns about the potential for environmental toxicity. Here, the authors explore the use of humic acid, traditionally considered to reduce graphene nanosheet toxicity, and show the coating has increased toxicity to model bacteria.

Fracture behaviours in multilayer h-BN, involving interlayer-friction toughening and edge-reconstruction embrittlement, are identified through in situ experiments and theoretical analyses.

The effect of the lattice degrees of freedom on the metal-insulator transition of VO₂ remains a topic of debate. Here the authors show that the lattice compatibility of the high temperature tetragonal phase and the low-temperature monoclinic phase strongly influences the electronic transition, as manifested in the tunability of its hysteresis via chemical substitution.

Cancer patients suffer from dysgeusia. Here, the authors propose a gustatory interface for operative assessment and taste decoding, offering potential to improve the quality of life of individuals suffering from tongue cancer.

Water scarcity is a global issue that demands urgent resolution, but current approaches are inadequate. Now a metre-scale atmospheric water harvester, featuring a hygroscopic origami hydrogel panel and a window-like glass chamber, demonstrates exceptional efficiency in extracting water from air, even in extremely arid conditions.

A long- and short-read barley pan-transcriptome assembled from 20 diverse barley genotypes offers insights into genotype- and tissue-dependent gene expression and function.

Recently, superconductivity near 80 K was observed in La3Ni2O7 under high pressure, but the mechanism is debated. Here the authors report angle-resolved photoemission spectroscopy measurements under ambient pressure, revealing flat bands with strong electronic correlations that could be linked to superconductivity.

An electron and a hole trapped in the same quantum dot couple together to form an exciton. Conventionally the hole involved is a heavy hole. Light-hole excitons are now observed by applying elastic stress to initially unstrained gallium arsenide-based dots. The quasiparticles are identified by their optical emission signature, and could be used in future quantum technologies.