Nature Search

AI-based large-scale screening of gastric cancer from noncontrast CT imaging

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Can Hu
Yingda Xia
Xiangdong Cheng
ResearchOpen Access24 Jun 2025
Nature Medicine

Volume: 31, P: 3011-3019
De novo biosynthesis of plant lignans by synthetic yeast consortia

Reconstructing the biosynthesis of complex natural products in yeast is challenging. Here the authors construct a yeast consortium with obligate mutualism aiming to alleviate metabolic promiscuity through the multicellular division of labor, similar to plants, for de novo synthesis of complex antiviral lignans.

Ruibing Chen
Xianghui Chen
Lei Zhang
Research17 Mar 2025
Nature Chemical Biology

Volume: 21, P: 1487-1496
An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

Lei Li
Meina Lu
Ying Su
ResearchOpen Access19 Apr 2025
Nature Communications

Volume: 16, P: 1-20
Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes

Both cartilaginous and bony fishes have adaptive immune cells, but the evolutionary features of these diverse cell populations remain understudied. Here the authors report single-cell RNA sequencing atlas of both species to define these features and to find reduced evolutionary diversification of immune cells in cartilaginous fishes.

Hong-Yan Wang
Jian-Yang Chen
Changwei Shao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals

Monitoring the diversity of viruses infecting animals is important for assessing zoonotic risk. Here, the authors use metatranscriptomics to characterise the viromes of small mammals, pangolins, and zoo animals in China to identify potentially zoonotic viruses.

Xinyuan Cui
Kewei Fan
Yongyi Shen
ResearchOpen Access29 Apr 2023
Nature Communications

Volume: 14, P: 1-13
Microbial risk assessment across multiple environments based on metagenomic absolute quantification with cellular internal standards

A cellular spike-in metagenomic method for absolute quantification of microorganisms in the aquatic environment is used to develop a risk assessment framework to support informed water quality management and policy decisions.

Xianghui Shi
Yu Yang
Tong Zhang
Research22 Apr 2025
Nature Water

Volume: 3, P: 473-485
Author Correction: Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast

Ruibing Chen
Jiaoqi Gao
Yongjin J. Zhou
Amendments and Corrections16 Aug 2022
Nature Chemical Biology

Volume: 18, P: 1032
High-entropy sulfoselenide as negative electrodes with fast kinetics and high stability for sodium-ion batteries

Conversion electrodes with fast charging capability and extended lifespan remains challenging. Here, authors developed Cu_0.88Sn_0.02Sb_0.02Bi_0.02Mn_0.02S_0.9Se_0.1 with entropy-driven fast-charging capability as negative electrode for sodium-ion batteries, enabling fast charging up to 100 A g⁻¹.

Shengfeng Zhang
Wenhua Zuo
Gui-Liang Xu
ResearchOpen Access30 Apr 2025
Nature Communications

Volume: 16, P: 1-13
Toward skillful forecasting of super El Niño events using a diffusion-based westerly wind burst parameterization

Chaopeng Ji
Mu Mu
Xianghui Fang
ResearchOpen Access19 Jul 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-11
Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution

Lymphocyte subsets remain inadequately understood in jawless vertebrates, relative to jawed vertebrates. In this study, the authors combine single-cell RNA and whole-transcriptome sequencing to demonstrate that the lamprey, Lampreta morii, harbours specialised T-like cells that are distinct from those found in jawed vertebrates.

Yingyi Huang
Xiang Liu
Changwei Shao
ResearchOpen Access03 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Publisher Correction: Pore elimination mechanisms during 3D printing of metals

S. Mohammad H. Hojjatzadeh
Niranjan D. Parab
Lianyi Chen
Amendments and CorrectionsOpen Access30 Sept 2019
Nature Communications

Volume: 10, P: 1
Integrated rocksalt–polyanion cathodes with excess lithium and stabilized cycling

Energy density and cyclability are often a trade-off for lithium-ion batteries. The authors develop cobalt- and nickel-free cathodes with both good cycling stability and high energy density through the integration of polyanion units into rocksalt structures.

Yimeng Huang
Yanhao Dong
Ju Li
Research23 Aug 2024
Nature Energy

Volume: 9, P: 1497-1505
Diagnostic evaluation of a deep learning model for optical diagnosis of colorectal cancer

Colonoscopy is the most commonly used tool to screen for colorectal cancer (CRC). Here, the authors develop a deep learning model to perform optical diagnosis of CRC by training on a large data set of white-light colonoscopy images and achieve endoscopist-level performance on three independent datasets.

Dejun Zhou
Fei Tian
Xiangchun Li
ResearchOpen Access11 Jun 2020
Nature Communications

Volume: 11, P: 1-9
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast

Engineering the biosynthesis, compartmentalization and recycling of three cofactors enables increased production of caffeic acid and ferulic acid in yeast, suggesting that these strategies could improve metabolic flux to other desirable compounds.

Ruibing Chen
Jiaoqi Gao
Yongjin J. Zhou
Research28 Apr 2022
Nature Chemical Biology

Volume: 18, P: 520-529
A dual-core model for ENSO diversity: unifying model hierarchies for realistic simulations

Jinyu Wang
Xianghui Fang
Chaopeng Ji
ResearchOpen Access14 Jul 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-12
Formation of three-dimensional bicontinuous structures via molten salt dealloying studied in real-time by in situ synchrotron X-ray nano-tomography

Understanding how pores evolve in metals submerged in molten salts is important for nanofabrication technology and molten salt corrosion in nuclear and solar power plants. Here, the authors present an in situ X-ray 3D imaging to directly visualize and quantify the process.

Xiaoyang Liu
Arthur Ronne
Yu-chen Karen Chen-Wiegart
ResearchOpen Access09 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Microstrain screening towards defect-less layered transition metal oxide cathodes

In situ synchrotron X-ray tools are used to perform microstrain screening during solid-state synthesis of battery materials, leading to fewer structural defects and improved performance.

Wenhua Zuo
Jihyeon Gim
Khalil Amine
Research20 Aug 2024
Nature Nanotechnology

Volume: 19, P: 1644-1653
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models

Expansion of synovial fibroblast is associated with rheumatoid arthritis (RA) progression, but how this expansion is regulated is still not clear. Here the authors use a mouse RA model, single cell RNA sequencing and in vitro analyses to show that inducing ferroptosis and suppressing TNF signaling reduce fibroblast numbers and ameliorate experimental arthritis.

Jiao Wu
Zhuan Feng
Ping Zhu
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-16
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection

Understanding the mechanisms of SARS-CoV-2 infection is important to control the pandemic. Here the authors show the biological and pathological role of RNA G-quadruplex structure in both SARS-CoV-2 genome and host factors, particularly TMPRSS2.

Geng Liu
Wenya Du
Xianghui Fu
ResearchOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1-13
Acidification of subsurface coastal waters enhanced by eutrophication

Eutrophication increases the acidity of coastal waters. Model simulations suggest that the drop in pH in coastal waters of the northern Gulf of Mexico since pre-industrial times is greater than that expected from eutrophication and ocean acidification alone.

Wei-Jun Cai
Xinping Hu
Gwo-Ching Gong
Research23 Oct 2011
Nature Geoscience

Volume: 4, P: 766-770
Terahertz wave modulation enhanced by laser processed PVA film on Si substrate

Weimin Liu
Fei Fan
Shengjiang Chang
ResearchOpen Access29 May 2018
Scientific Reports

Volume: 8, P: 1-6
Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer

Signet-ring cell carcinoma (SRCC) is a unique type of gastric cancer with no prognostic features. Here, the authors report a CLDN18-ARHGAP26/6 gene fusion in patients with a high signet-ring cell content, poor survival outcomes, and who experience no benefit from platinum/fluoropyrimidines-based chemotherapy.

Yang Shu
Weihan Zhang
Jiankun Hu
ResearchOpen Access30 Jun 2018
Nature Communications

Volume: 9, P: 1-11
A single-cell plume transcriptome atlas of the cold-seep tubeworm Paraescarpia echinospica

Yingying Zhang
Xianghui Zhang
Liang Meng
ResearchOpen Access17 Jun 2025
Scientific Data

Volume: 12, P: 1-8
Serum branched-chain amino acids are associated with leukocyte telomere length and frailty based on residents from Guangxi longevity county

Ying Zhang
Qi Zhou
Liang Sun
ResearchOpen Access24 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
Insights into interfacial effect and local lithium-ion transport in polycrystalline cathodes of solid-state batteries

Solid state battery is regarded as one of the most promising next generation energy storage systems due to high safety and high energy density. Here, authors demonstrate the importance of interfacial local environment in polycrystalline cathodes for electrochemical reactions in solid-state batteries.

Shuaifeng Lou
Qianwen Liu
Jiajun Wang
ResearchOpen Access11 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces

A biocompatible and biodegradable mesostructured form of silicon is used to make lipid-bilayer-supported bioelectric interfaces that can optically modulate the electrophysiology of single dorsal root ganglia neurons.

Yuanwen Jiang
João L. Carvalho-de-Souza
Bozhi Tian
Research27 Jun 2016
Nature Materials

Volume: 15, P: 1023-1030
Pore elimination mechanisms during 3D printing of metals

3D printing pore-free complex metal parts remains a challenge. Here, the authors combine in-situ imaging and simulations to show thermocapillary force can eliminate pores from the melt pool during a laser powder bed fusion process.

S. Mohammad H. Hojjatzadeh
Niranjan D. Parab
Lianyi Chen
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-8
A novel multifunctional NiTi/Ag hierarchical composite

Shijie Hao
Lishan Cui
Yang Ren
ResearchOpen Access12 Jun 2014
Scientific Reports

Volume: 4, P: 1-6
Transformation-optical Fan-beam Synthesis

Rui Yang
Xianghui Kong
Lei Chen
ResearchOpen Access05 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4

Min Su
Jingjia Huang
Zhiyong Luo
ResearchOpen Access24 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
SDC4 identified as an oncogenic target gene of NF-κB in TNFα-Induced tumor cells

Fei Zhou
Yuanduo Li
Hui Zhu
ResearchOpen Access08 May 2025
Scientific Reports

Volume: 15, P: 1-11
Performance analysis of an adaptive optics system for free-space optics communication through atmospheric turbulence

Yukun Wang
Huanyu Xu
Zhaoliang Cao
ResearchOpen Access18 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing

In this study, the authors have investigated if the implantation of fibrin gel loaded with platelet-rich plasma-derived exosomes is a feasible strategy to treat rotator cuff injuries. In fact, this strategy proved to promote tendon repair and healing outcomes in a rabbit model of rotator cuff injury.

Molin Li
Lin Shi
Yuexiang Wang
ResearchOpen Access20 Feb 2024
Communications Biology

Volume: 7, P: 1-15
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

Dan Tang
Chunjing Chen
Shiqian Qi
ResearchOpen Access18 Feb 2020
Cell Discovery

Volume: 6, P: 1-11
Psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools after the COVID-19 pandemic: a national cross-sectional study in China

Lin Wang
Yiwen Zhang
Tingyu Li
ResearchOpen Access03 Jun 2021
Translational Psychiatry

Volume: 11, P: 1-12
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma

Jiejie Geng
Liang Chen
Zhi-Nan Chen
ResearchOpen Access25 Sept 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-13
CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis

Jiao Wu
Liang Chen
Zhi-Nan Chen
ResearchOpen Access25 Nov 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Evolution of micro-pores in Ni–Cr alloys via molten salt dealloying

Lin-Chieh Yu
Charles Clark
Yu-chen Karen Chen-Wiegart
ResearchOpen Access01 Dec 2022
Scientific Reports

Volume: 12, P: 1-12
MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression

Liping Ma
Xiaoxue Yang
Yong Peng
ResearchOpen Access18 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-13
A multi-targeting immunotherapy ameliorates multiple facets of Alzheimer’s disease in 3xTg mice

Xuejian Feng
Yunyu Hou
Hui Wu
ResearchOpen Access20 Aug 2024
npj Vaccines

Volume: 9, P: 1-17
CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis

JieJie Geng
Ruo Chen
Ping Zhu
ResearchOpen Access10 Nov 2021
Cellular & Molecular Immunology

Volume: 18, P: 2618-2631
The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease

Yongli Song
Christian F. Guerrero-Juarez
Zhengquan Yu
Research26 May 2020
Cell Research

Volume: 30, P: 854-872
Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis

Chao Dou
Zhaolin Long
Wei Cheng
ResearchOpen Access02 Feb 2022
Cell Research

Volume: 32, P: 302-314
A multiscale model for El Niño complexity

Nan Chen
Xianghui Fang
Jin-Yi Yu
ResearchOpen Access11 Mar 2022
npj Climate and Atmospheric Science

Volume: 5, P: 1-13
DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury

Yinwu Bao
Mengqiu Bai
Weiqiang Lin
ResearchOpen Access17 Jun 2021
Cell Death Discovery

Volume: 7, P: 1-11
The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy

Fan Liang
Chunxia Ren
Gong Yang
ResearchOpen Access09 Oct 2019
Oncogenesis

Volume: 8, P: 1-15
Red cell distribution width as a significant indicator of medication and prognosis in type 2 diabetic patients

Xiao-fen Xiong
Yuan Yang
Lin Sun
ResearchOpen Access02 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome

Xiwen Dong
Zhaohui Zheng
Ping Zhu
Research25 Mar 2019
Cellular & Molecular Immunology

Volume: 17, P: 261-271
Gene expression profiling in peripheral blood lymphocytes for major depression: preliminary cues from Chinese discordant sib-pair study

Chan Wu
Danfeng Wang
Hui Xiang
ResearchOpen Access19 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-9
Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta)

Lifang Jin
Shaohui Ji
Weizhi Ji
Correspondence20 Jan 2009
Cell Research

Volume: 19, P: 268-270

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