Nature Search

Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies

Ya-Jun Guo
Xiao-Yan Che
Meng-Chao Wu
Research01 Apr 1997
Nature Medicine

Volume: 3, P: 451-455
Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy

The carryover of mitochondrial DNA in mitochondrial replacement therapy can be reduced via forced mitophagy by pre-labelling the mitochondrial outer membrane of a donor zygote with an autophagy receptor, as shown in mouse and human embryos.

Xiao-Yan Fan
Lei Guo
Shi-Ming Luo
Research18 Apr 2022
Nature Biomedical Engineering

Volume: 6, P: 339-350
Pregnant phenotype in aquaporin 8-deficient mice

Xiao-yan Sha
Zheng-fang Xiong
Tong-hui Ma
Research23 May 2011
Acta Pharmacologica Sinica

Volume: 32, P: 840-844
Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes

Jiang Li
Shen-jiang Hu
Xiao-yan Zhao
Research01 Jan 2005
Acta Pharmacologica Sinica

Volume: 26, P: 51-55
Correction: CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Xin-Yuan Lyu
Yuan Deng
Chun-Qing Song
Amendments and CorrectionsOpen Access14 Nov 2022
Cell Research

Volume: 32, P: 1133
Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses

Xiao Gao
Yan Wu
Xiao-yan Pan
ResearchOpen Access03 Sept 2025
Acta Pharmacologica Sinica

P: 1-13
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population

Xue-Jun Zhang, Zhi-Rong Yao and colleagues report a genome-wide association study for atopic dermatitis in the Chinese Han population. They identified two new susceptibility loci at 5q22 and 20q13.

Liang-Dan Sun
Feng-Li Xiao
Xue-Jun Zhang
Research12 Jun 2011
Nature Genetics

Volume: 43, P: 690-694
CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats

Ye Xu
Yi-fan Zhang
Da-fang Zhong
Research28 Dec 2017
Acta Pharmacologica Sinica

Volume: 39, P: 1386-1392
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Xue-Jun Zhang
Wei Huang
Jian-Jun Liu
Research25 Jan 2009
Nature Genetics

Volume: 41, P: 205-210
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective function, and shows efficacy in animal models.

Xiao-Yan Zhao
Andreas Wilmen
Volker Laux
ResearchOpen Access12 Jun 2020
Nature Communications

Volume: 11, P: 1-14
A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities

Min He
Ni Guan
Ming-wei Wang
Reviews03 Feb 2012
Acta Pharmacologica Sinica

Volume: 33, P: 148-154
LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1α-CXCR4 pathway

Cardiac hypertrophy is a common cardiovascular disease worldwide, and this study may provide novel potential therapeutic targets. The authors demonstrate that TINCR improves cardiac hypertrophy by acting as a competitive endogenous RNA for miR-211-3p and thus relieving its suppressive effects on the VEGFB-SDF-1α-CXCR4 signalling axis.

Shan Tu
Xiao-Yan Wang
Zhi-Hui Zhang
Research03 Nov 2021
Laboratory Investigation

Volume: 102, P: 253-262
Direct copolymerization of ethylene with protic comonomers enabled by multinuclear Ni catalysts

The applications of polyolefins are limited by the nonpolar nature of the polymer. Here the authors show a method to copolymerize ethylene with the protic vinyl acetic acid via well defined multinuclear nickel catalysts.

Gang Ji
Zhou Chen
Yong Tang
ResearchOpen Access01 Nov 2021
Nature Communications

Volume: 12, P: 1-9
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl ¹H-NMR probe

Characterization of dynamic conformational changes in membrane protein complexes by NMR spectroscopy remains challenging. Here authors report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMSiPhe) into proteins, which enabled the characterization of multiple conformational states of a phospho-β2 adrenergic receptor/β-arrestin-1 complex in response to different receptor ligands.

Qi Liu
Qing-tao He
Jin-peng Sun
ResearchOpen Access25 Sept 2020
Nature Communications

Volume: 11, P: 1-17
A transcriptome data set for comparing skin, muscle and dorsal root ganglion between acute and chronic postsurgical pain rats

Xiao-yan Meng
Lan Bu
Kun-ming Tao
ResearchOpen Access14 Nov 2024
Scientific Data

Volume: 11, P: 1-8
Birth weight changes in a major city under rapid socioeconomic transition in China

Jian-Rong He
Wei-Dong Li
Xiu Qiu
ResearchOpen Access21 Apr 2017
Scientific Reports

Volume: 7, P: 1-8
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations.

Jian-Wen Han
Hou-Feng Zheng
Xue-Jun Zhang
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1234-1237
Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the Aβ/Kv2.1/JNK/NF-κB/NLRP3/p-Tau pathway

Jia-wen Xu
Lin Ma
Xu Shen
Research20 Mar 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2163-2179
CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Xin-Yuan Lyu
Yuan Deng
Chun-Qing Song
ResearchOpen Access14 Sept 2022
Cell Research

Volume: 32, P: 969-981
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming

Ping Wang
Jin-mei Jin
Xiao-jun Wu
Research30 Aug 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1581-1593
Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model

Feng-Di Liu
Rong Zhao
Jian-Ren Liu
ResearchOpen Access09 May 2018
Scientific Reports

Volume: 8, P: 1-9
TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells

Tong Wu
Da-Lin Zhang
Zhen-Xian Du
ResearchOpen Access29 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-15
Thymic homing of activated CD4⁺ T cells induces degeneration of the thymic epithelium through excessive RANK signaling

Chen Yin
Xiao-Yan Pei
Yu Zhang
ResearchOpen Access25 May 2017
Scientific Reports

Volume: 7, P: 1-12
Heat Shock Factor 1 Mediates Latent HIV Reactivation

Xiao-Yan Pan
Wei Zhao
Shu-Wen Liu
ResearchOpen Access18 May 2016
Scientific Reports

Volume: 6, P: 1-12
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

Bingqing Xia
Xiaoyan Pan
Zhaobing Gao
ResearchOpen Access06 Jan 2023
Cell Discovery

Volume: 9, P: 1-15
A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

Wei Pang
Ying Lu
Yong-Tang Zheng
ResearchOpen Access10 Nov 2022
Cell Research

Volume: 32, P: 1068-1085
Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics

Wen-si Zhao
Kai-feng Chen
Min-jia Tan
Research17 Mar 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1701-1711
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Zhen Wang
Fan-lian Zeng
Jiong Li
ResearchOpen Access20 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-17
Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

Chun-Hong Jia
Zhou-Shan Feng
Fan Wu
ResearchOpen Access01 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

Yu-bo Zhou
Yang-ming Zhang
Jian Hou
ResearchOpen Access02 Aug 2021
Acta Pharmacologica Sinica

Volume: 43, P: 1091-1099
MicroRNA-induced negative regulation of TLR-5 in grass carp, Ctenopharyngodon idella

Xiao-Yan Xu
Yu-Bang Shen
Jia-Le Li
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Discovery of novel xylosides in co-culture of basidiomycetes Trametes versicolor and Ganoderma applanatum by integrated metabolomics and bioinformatics

Lu Yao
Li-Ping Zhu
Song Yang
ResearchOpen Access12 Sept 2016
Scientific Reports

Volume: 6, P: 1-13
Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD

Wen-qi Diao
Ning Shen
Bei He
ResearchOpen Access22 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy

Ya-nan Liang
Luo Chen
Yan You
Reviews17 Apr 2025
Acta Pharmacologica Sinica

Volume: 46, P: 2587-2596

Search

Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies

Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy

Pregnant phenotype in aquaporin 8-deficient mice

Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes

Correction: CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Salvianolic acid A from Salvia miltiorrhiza identified as a cap-dependent endonuclease inhibitor for pathogenic arenaviruses

Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population

CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats

Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21

Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities

LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1α-CXCR4 pathway

Direct copolymerization of ethylene with protic comonomers enabled by multinuclear Ni catalysts

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl ¹H-NMR probe

A transcriptome data set for comparing skin, muscle and dorsal root ganglion between acute and chronic postsurgical pain rats

Birth weight changes in a major city under rapid socioeconomic transition in China

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the Aβ/Kv2.1/JNK/NF-κB/NLRP3/p-Tau pathway

CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming

Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model

TRIM29 inhibits miR-873-5P biogenesis via CYTOR to upregulate fibronectin 1 and promotes invasion of papillary thyroid cancer cells

Thymic homing of activated CD4⁺ T cells induces degeneration of the thymic epithelium through excessive RANK signaling

Heat Shock Factor 1 Mediates Latent HIV Reactivation

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

MicroRNA-induced negative regulation of TLR-5 in grass carp, Ctenopharyngodon idella

Discovery of novel xylosides in co-culture of basidiomycetes Trametes versicolor and Ganoderma applanatum by integrated metabolomics and bioinformatics

Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD

Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy

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