Search

Photonics reconfigurable memristor simulate volatile and non-volatile properties to achieve dynamic modulation of neurons and synapses and demonstrate application scenarios.

All-electrical switching of magnetization holds promise for applications in information technologies with low power consumption. Here, current-induced spin–orbit torque switches the magnetization in SrIrO₃/SrRuO₃ bilayer structures at 70 K in the absence of an external magnetic field.

Blue light-emitting diodes based on perovskite nanostructures embedded within quasi-two-dimensional phases show highly effective charge injection and suppressed non-radiative recombination.

Companion diagnostics using biomarkers are promising for guiding radiotherapy, but biopsy-based techniques normally fail to detect real-time variations in target response and tumor heterogeneity. Herein, the authors report an activated afterglow/MRI probe as a companion diagnostics tool for dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy in vivo.

Efficient CO₂ photoreduction in pure water remains challenging. Here, the authors propose to use van der Waals gaps-rich BiOCl atomic layers with low exciton binding energy and abundant surface oxygen vacancies for CO₂ to CO conversion.

A genome-wide association study of Mycobacterium tuberculosis clinical isolates finds mutations in prpR that alter propionate metabolism and mediate multidrug tolerance.

Ferroelectric hafnia-based thin films are promising for applications in memories and neuromorphic devices due to their robust ferroelectricity at reduced dimensions. Here, the authors demonstrate stabilization of the metastable orthorhombic phase in Hf_0.5 Zr_0.5O₂ films by interface engineering with a hole doping mechanism.

Environmental drivers of soil carbon and its sensitivity to warming are poorly understood. The authors compare soil samples of paired urban and natural ecosystems and show that under warming, the microbiome is an essential driver of soil carbon in urban greenspace compared with natural ecosystems.

In a widespread sampling campaign across urban soils, the authors find that soil biodiversity, but not plant diversity, is positively related to multiple ecosystem functions in urban environments.

Cells communicate with the outside world to maintain homeostasis. Here the authors design a synthetic biology DNA-based signalling system AMSsys that responds to the presence of ATP.

Metal nanoparticle-decorated carbon supports are vital for many applications, ranging from energy storage and catalysis to filtration and environmental remedies. Here, using real-time electron microscopy of a single carbon nanofiber during Joule heating, the authors report atomistic mechanisms responsible for nucleation and stabilization of nanoparticles on amorphous carbon supports.

EGLN2 hydroxylates histone H3 at proline 16, enhancing the binding of KDM5A to H3K4me3. Genome- and transcriptome-wide analyses show that the EGLN2–KDM5A axis regulates target gene expression in mammalian cells.

a Aging-time dependent saturation magnetostriction for Fe₇₃Ga₂₇ random polycrystals. Bright-field images for the b 1373 K-quenched, c 1 h-aged and d 12 h-aged Fe₇₃Ga₂₇ random polycrystals. e Figure of merit as a function of aging time for Fe₈₁Ga₁₉ random polycrystals. f Comparison of saturation magnetostriction among our optimally aged Fe–Ga random polycrystals, the quenched random polycrystals doped with a third element and the single crystals.

Deformation of the Himalaya and Tibet is thought to relate to flow within a weak crustal channel at depth. Magnetotelluric imaging of the Earth’s subsurface reveals a complex pattern of deformation, with two distinct weak crustal channels at 20–40 km depth.

Clay-based nanomaterials are of wide interest but problems extracting the 2D functional core layers have limited potential applications. Here, the authors report on the wet exfoliation of vermiculite by alkali etching to obtain the core layers and explore the application of the materials in cancer theranostics.

For many neurodevelopmental disorder (NDD) risk genes, the significance for mutational burden is unestablished. Here, the authors sequence 125 candidate NDD genes in over 16,000 NDD cases; case-control mutational burden analysis identifies 48 genes with a significant burden of severe ultra-rare mutations.

Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk of post-transcriptional dysregulation.

Ding Ma, Xing Xie, Yongyong Shi and colleagues report a genome-wide association study of cervical cancer in the Han Chinese population. They identify two new susceptibility lociat 4q12 and 17q12.

DNA-mediated assembly of hollow nanoparticles can be used in an edge-bonding approach to design and synthesize nanoscale open-channel superlattices, with control of symmetry, geometry and topology.

Recurrent sporadic mutations are important risk factors for autism spectrum disorders (ASDs) but have been primarily investigated in European cohorts. Here, Eichler, Xia and colleagues analyse risk genes in a large Chinese ASD cohort and find novel recurrences of potential pathogenic significance.

A biocompatible and biodegradable mesostructured form of silicon is used to make lipid-bilayer-supported bioelectric interfaces that can optically modulate the electrophysiology of single dorsal root ganglia neurons.

Different mechanisms for generating antibody diversity have evolved since the emergence of immunoglobulin genes in jawed vertebrates. By sequencing the crocodilian immunoglobulin heavy-chain locus, Chenget al. uncover new insights into the evolutionary origins of adaptive immunity.

A global field survey that analyses samples of soil from all continents identifies hotspots for soil nature conservation, and shows that different ecological dimensions of soil are associated with different priority areas for conservation.

Yu et al. identify that STING bicondensates occur in virus-infected cells, thereby restricting TBK1 activation and innate immunity.

The histone acetyltransferase p300 mostly localizes to active chromatin; however, some repressed genes marked with H3K27me3 are also bound by p300. Here the authors show p300 is capable of phase separation, which relies on its catalytic core, and that p300 catalytic activity is decreased in phase-separated droplets that co-localize with H3K27me3-marked chromatin.

Previous methods to generate strain gradient and flexoelectricity are limited to a localized effect or cannot be tuned continuously. Here, the authors achieve macroscale continuously controllable strain gradient in freestanding ferroelectric thin film. Multilevel photoconductance in BiFeO3 films can be achieved by coupling between the flexoelectric and ferroelectric photovoltaic effect.

YEATS domains are histone acylation readers that recognize crotonyllysine and acetyllysine. Here the authors provide structural insights into how YEATS domains recognize acetyllysines and further show that the human AF9 YEATS domain also binds DNA.

An inhibitor of the YEATS domain was developed by targeting a unique π-π-π stacking in the YEATS–Kcr recognition. An ENL YEATS-selective inhibitor, XL-13m, helps probe the YEATS-dependent role of ENL in the leukemogenic transcription program.

Upgrading CO to high-value multicarbon products is a promising avenue for fuel and chemical feedstock production. Here triangular Cu nanosheets that selectively expose the (111) surface exhibit a high acetate partial current density (131 mA cm^–2) and Faradaic efficiency (48%) in CO electroreduction.

Unraveling the structural origin of liquid anomalies remains a challenging topic. Xu et al. propose a folded-network structural model for molten tin and provide insights into the observed second-order-like structural transition.