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Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

In the pre-synapse, vesicle fusion is a key process for neurotransmitter release in the nervous system. Here authors demonstrate under pathological condition, synaptotagmin1 with Zn²⁺ adopts an alternative mode to regulate spontaneous neurotransmitter release.

Exploiting as many degrees of freedom of the electron as possible will make future electronic devices more versatile. Here, the authors show that coupling of spin, layer pseudospin and valley degrees of freedom in transition metal dichalcogenide bilayers makes them a promising platform for this purpose.

Topological materials hold great promise for dissipationless information transmission. Here, the authors create Chern insulator junctions between domains with different Chern numbers in MnBi₂Te₄ to realize the basic operation of a topological circuit.

The mechanism through which auxin regulates chilling tolerance remains unclear. Here, the authors discover a negative regulator of chilling tolerance in japonica rice, which encodes an ABCB transporter with auxin efflux function, and show its potential to increase indica rice chilling tolerance.

In the IMpower151 trial, the drug combination previously shown to be effective in the IMpower150 trial was not significantly effective in a Chinese population.

Solvation structure engineering in electrolytes enhances the cyclability of lithium-metal anodes, but it also results in compromised ionic conductance and subsequently poor rate capability. Now, a high-entropy electrolyte is designed to improve ionic conductivity while maintaining cyclability.

Quantum anomalous Hall junctions show great promise for advancing next-generation electronic circuits. Here, the authors demonstrate a scalable method for synthesizing heterostructures of magnetic topological insulators with regions of distinct Chern numbers and characterize the chiral interface modes that emerge at the interface.

The nanoscale measurement of electronic bandgaps is crucial for material characterization, but it is usually performed under cryogenic conditions. Here, the authors report a scanning probe method to determine the electronic bandgap of 2D semiconductors at the nanoscale by monitoring their quantum capacitance under ambient conditions.

Van der Waals magnetic materials are characterized by strong magnetic interactions within each van der Waals layer, while the interaction between the layers is typically weaker. Here, Liu, Su, Gu and coauthors find a magnetic phase transition in the van der Waals magnet, NiI₂, under hydrostatic pressure, which they associate with the interlayer magnetic interaction.

Phonons are the collective excitations of the lattice of a material, and can, in the case of chiral phonons, carry angular momentum, allowing for strong coupling to the magnetic properties of the material. Here, Cui, Bostrom and co-authors observe chiral magnon polarons, the hybridized quasiparticles of chiral phonons and magnons, in the van der Waals antiferromagnet FePSe₃.

Using deep brain stimulation of the habenula with implanted electrodes in patients with treatment-resistant depression, this study found a substantial reduction in depression scores at follow-up over multiple time points.

Conventional propylene epoxidation uses corrosive oxidants, facing separation issues and instability. Here, the authors report an Ag-V catalyst in membrane electrode assembly system for propylene oxide production via direct electro-epoxidation, eliminating oxidants and enabling instant separation.

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

The ectoenzyme CD73 is often elevated in tumour environments and targeting this protein is a tumour therapeutic target. Here the authors characterise a therapeutic anti-CD73 antibody cocktail which is more effective than either antibody alone and suggest a molecular mechanism of how this antibody cocktail functions.

Here, the authors present structural and mechanistic characterisation of the UDP-dependent glycosyltransferase SgUGT94-289-3, which generates two mogrosides of interest as natural sweeteners. Structure-based engineering yielded variants with improved specificity and activity.

Twisted van der Waals structures have shown many emerging physical properties, but uniform moiré wavelengths are usually < 50 nm due to structural relaxation. Here, the authors report the fabrication of super-moiré structures based on graphene/twisted boron nitride, showing a homogeneous moiré wavelength up to 63.2 nm resulting in Brown-Zak oscillations at integer magnetic flux quanta.

Here, the authors introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method that considers the heterogeneity of sequenced bulk cells. They apply CHALM to methylation datasets to detect differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.

Jiang et al. identify Pax as a key regulator of Drosophila midgut homeostasis. Pax coordinates the Hippo and Notch pathways to control the proliferation and differentiation of intestinal stem cells (ISCs), ensuring homeostasis of midgut.

Min Deng, Kai Wang and colleagues report genome-wide association analyses of amyotrophic lateral sclerosis in the Han Chinese population. They identify two new risk loci at 1q32 and 22p11.

The connection between Mars’s global magnetospheric current systems and its ionosphere is still not well-defined. Here, the authors show a map of the magnetic fields and ionospheric currents of Mars, revealing two ionospheric currents that are driven by the solar wind and atmospheric neutral winds.

Although psoriasis is a chronic disorder affecting approximately 2% of the population, little is known about the underlying genetic architecture. Here, the authors carry out exome sequencing in a large Han Chinese cohort of psoriasis patients and healthy controls, and identify three new genes that may increase risk of developing the disease.

Exotic states emerge from the interplay between band topology and ferromagnetism, but it remains less known in canted-antiferromagnetic phase. Here, the authors realize a canted-antiferromagnetic Chern insulator in atomically-thin MnBi₂Te₄ with electrical control of chiral-edge state transport.

Bioluminescence imaging of neuronal activity is desired. Here the authors report a luciferase prosubstrate activatable in vivo by nonspecific esterase and engineer a bioluminescent indicator with responsiveness to calcium ions: integration of these components enabled imaging of neuronal activity in mice.

The Australian pitcher plant (Cephalotus sp.) genome reveals genetic changes associated with prey attraction, capture, digestion and nutrient absorption. Comparison with other carnivorous plants reveals constraints on evolution of plant carnivory

Doping carbon-based materials with nitrogen is effective for enhancing catalytic activity for oxygen reduction; however, directing nitrogen dopants to specific locations is difficult. Here the authors employ hydrogen-substituted graphdiyne as a matrix for nitrogen doping, leading to enhanced performance.

Cardiovascular disease diagnosis can be invasive and complex. Here, the authors present a flexible optoacoustic blood ‘stethoscope’ that noninvasively and continuously monitors cardiovascular health.

Using molecular-beam epitaxy, we synthesize heterostructures of topological insulator Bi₂Se₃ and the Ising superconductor monolayer NbSe₂. By changing the Bi₂Se₃ thickness, they demonstrate a crossover from Ising- to Rashba-type superconducting pairing.

The magnetic exchange interaction of MnBi₂Te₄—an intrinsic magnetic topological insulator—can be tuned by intercalating ferromagnetic layers of MnTe.

Circularly polarized light has been used to achieve a valley polarization of 30% in single-layer molybdenum disulphide.

An artificial neuron that detects dopamine using a carbon-based electrochemical sensor and then processes the sensory signals using a memristor with synaptic plasticity, before stimulating dopamine release via a heat-responsive hydrogel, can be used to trigger the controllable movement of a mouse leg and robotic hand.

Genetic fine-mapping and CRISPRi screens identify functional variants and their target genes associated with Alzheimer’s disease in microglia. The variant rs7922621 modulates AD risk through control of TSPAN14 expression in this cell type.

A high-throughput yeast display platform is used to analyse the profiles of mutations in the SARS-CoV-2 receptor-binding domain (RBD) that enable escape from antibodies, and suggests that most anti-RBD antibodies can be escaped by the Omicron variant.

Transport measurements in twisted bilayer MoTe₂ reveal quantized Hall resistance plateaus and composite Fermi liquid-like behaviour under zero magnetic field, constituting a direct observation of integer and fractional quantum anomalous Hall effects.

The histone-acetylation-reader protein ENL is mutated in a paediatric kidney cancer in such a way that it clusters at target genes, increasing the recruitment of the transcriptional machinery, enhancing transcription and deregulating cell fate during development.

Designing efficient systems capable emulating the muscular excitation-contraction signatures, remains a challenge. Here, the authors propose cytoadhesion-inspired hybrids as locally-coupled electromechanical interfaces capable retrieving the myoelectric and mechanical signals.

Shape morphing offers a promising method to transform 2D electronics into 3D structured devices. Here authors show a shape morphing strategy of homogeneous inert plastic thin films into free-standing 3D frameworks by programming the plastic strain in films under peeling.

Psoriasis is a chronic inflammatory disease affecting up to 3% of the population. Here, Zuo et al.perform exome array analysis, identify single-nucleotide polymorphisms at 15 new loci, implicating several biological pathways in psoriasis risk and disease heritability.

Lusheng Huang, Jun Ren and colleagues report the genome sequences of 69 pigs, representing 11 geographically distinct breeds and 3 wild boar populations, from within China. They identify loci related to high- and low-latitude adaptation and infer a likely ancient introgression event in northern Chinese pigs.

Exciton condensation has been observed in various three-dimensional (3D) materials. Now, monolayer WTe₂—a 2D topological insulator—also shows the phenomenon. Strong electronic interactions allow the excitons to form and condense at high temperature.

While dry reforming of methane, the reaction of CH₄ and CO₂ to create CO and H₂, is a promising reaction for industry, coke buildup often deactivates catalysts and limits commercialization. Here, authors report single-atom nickel on Ce-doped hydroxyapatite as a coke-resistant catalyst.