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A single umbilical cord blood unit of CD34⁺ HSPCs produces a high number of CD19 CAR-iNK cells using a modified cell culture method.

Autonomous artificial intelligence (AI) models to replace human decision-making in medical intervention need thorough testing. Here authors present the results of a clinical trial, NCT05600855, in which daGOAT, a conditional autonomous artificial intelligence agent successfully makes the decision whether to prescribe an immune suppressive drug to prevent severe acute graft-versus-host disease following HLA-mismatched haematopoietic cell transplantation.

The reduction of carbon dioxide (CO₂) to value-added products using sunlight is an attractive technology, especially if multi-carbon products are yielded. Now, the efficient photocatalytic conversion of CO₂ to ethylene is demonstrated by filling the pores of a copper-based metal–organic framework with semiconductor nanoparticles.

High frequency microwave is crucial for communication and radar applications. The authors develop a compact Kerr comb for photonic THz generation with near quantum limited noise performance, enabling record-breaking 240 Gbps wireless communication.

Zero-dimensional metal halides exhibit intriguing photophysical properties; however, developing their general design principles remains challenging. Now it has been shown that two-dimensional perovskites can be converted into zero-dimensional octahedral metal halides through solvent incorporation. The resulting materials feature near-unity photoluminescence quantum yields. Structural rigidity and the choice of metal cation are key parameters to tune the exciton recombination dynamics.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

Multiple sclerosis and some other neuroinflammatory diseases are associated with aberrant CD4⁺ T cell differentiation and regulatory T cell function. Here authors show that the E3 ubiquitin ligase RNF213 is central to both physiological and pathologic CD4⁺ T cell differentiation, and finetunes IFN-β responses in multiple sclerosis.

Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.

Tandem repeats (TRs) have unique ability to drive a range of phenotype variations. Here, the authors survey rice TR variations based on 231 genome assemblies and the rice pan-genome graph, identify TR variations associated with expressed genes, and reveal expression TRs contributed to rice agronomic trait variations.

Chromosome-scale genome assemblies of triploid Cavendish and Gros Michel reveal the banana cultivars’ origins, disease resistance and fruit ripening mechanism.

Decoding the pathogenic genes of the inherited anemia could provide us with novel regulators of pathological and physiological erythropoiesis. Here, the authors show TLR8 is expressed by erythroid cells and regulates erythropoiesis through interacting with EPO signaling.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Applications of edge states are rare. Here the authors utilize asymmetric edge states in the topological material Ta₂Pd₃Te₅ to achieve the interfering Josephson diode effect, exhibiting high efficiency with ultra-low switching power at very small magnetic fields.

Mesenchymal stem cells (MSC) are used for immunosuppressive therapy and a uniform source or heterogeneity characterisation is needed. Here the authors use multi-omics to compare human MSC from different sources and ages of donors and show differences in gene expression and immunosuppressive function.

Ye and colleagues show that an oncolytic virus that delivers tumor-irrelevant bystander T cell epitopes to tumor cells can exploit the abundant population of bystander T cells in the tumor for anti-tumor immunity and potentiate cancer immunotherapy.

A dynamic probabilistic algorithm that integrates many variables over time for forecasting severe acute graft-versus-host disease is proposed to improve healthcare decisions for individual patients on a case-by-case basis.

Li, Guo, Wang and colleagues show that the ion channels TMEM63 in Drosophila and TMEM63A in mouse mediate lysosomal mechanosensitivity and modulate lysosomal morphology and function.

It is challenging to increase carrier mobility in n-type Mg₃(Bi,Sb)₂ due to grain-boundary scattering. Here, authors reported a facile growth of coarse-grained Mg₃(Bi,Sb)₂ crystals with high carrier mobility. The as-fabricated module shows cooling performance comparable to commercial Bi₂Te₃ module.

Zhang et al. perform single-cell RNA and B-cell receptor sequencing to characterize the transcriptomic profiles of B-cell acute lymphoblastic leukaemia cells at diagnosis, residual and relapse stages, uncovering the hypoxia pathway as a potential target for residual leukaemia cells.

Trade-off between permeability and nanometer-level selectivity is an inherent shortcoming of membrane-based separation of molecules. Here, the authors report a membrane adsorption material based on hydrophilic amidoxime modified polymer of intrinsic microporosity to selectively adsorb and separate small organic molecules from water with ultrahigh processing capacity

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.

Yang and colleagues perform a network system–pharmacology approach and clinical data integration, and identify LCK and BCL2 signaling as the molecular determinants of dasatinib response in pediatric and adult patients with T-ALL.

Whole-genome sequencing coupled with whole-exome sequencing validation in Han Chinese patients reveals a diverse genetic basis for venous thromboembolism, and identifies GP6, TET2, and JAK2 as novel risk factors in East Asian populations.

Tao Cheng, Qian-fei Wang, Gang Huang and colleagues identify recurrent somatic loss-of-function mutations in SETD2 in individuals with acute leukemia. SETD2 encodes a histone H3K36 methyltransferase, and loss of SETD2 function causes global loss of H3K36 trimethylation and promotes leukemia stem cell self renewal.