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In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

Orthogonal chimeric receptors containing intracellular domains for IL-4R, IL-20R, IL-22R and GCSFR reprogram T cells to promote distinct natural and synthetic cell states with functional and therapeutic implications.

The authors develop a miniaturized Mg3Bi2-based thermoelectric cooler, achieving a high cooling power density of 5.7 W cm-2 and a cooling speed of 65 K s-1, demonstrating great promise for localized thermal management in electronics.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Zeng, Gan et al. investigated the molecular characteristics underlying the great obstetrical syndromes (GOS) in the pre-symptomatic phase. Their findings highlighted the shared molecular signatures among different GOS conditions in early pregnancy, suggesting the potential of a common screening and intervention strategy.

Plants perceive UVB from sunlight. For this, Arabidopsis thaliana use the receptor UVR8. Dynamic crystallography reveals early signalling structural events and intermediates between the homodimeric (inactive) and monomeric (active) states of UVR8.

Here, the authors use single-molecule long-read sequencing to decipher the role of structural variations in high-altitude adaptation, finding evidence that an intergenic deletion down-regulates EPAS1 by disrupting a super-enhancer.

RNA methylation has recently identified as an important regulatory mechanism governing functional cellular states, but its effect on the antitumour activity of CD8 ⁺ T cells is not fully explored. Here authors assign an essential nuclear, m⁶A-recognition-dependent function to YTHDF2, which, in conjunction with its regulatory role in IKZF1/3-mediated gene transcription, governs anti-tumor activity in CD8 ⁺ T cells.

SERS spectroscopy critically relies on the accumulation of analyte molecules in electromagnetic ‘hotspots’. Here, the authors demonstrate plasmonic trimers with central particles that act as chemical traps, enabling the subtyping of lung tumors using fresh tissue samples.

This study finds that during acute viral infection of the CNS, meningeal lymphatic vessels (MLVs) can transport virus from the CNS to draining cervical lymph nodes. VEGF-C-induced expansion of functional MLVs facilitated virus clearance.

Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid tumours in small animals.

The authors obtain the TiCoSb-based single-crystals with a dimension exceeding 1 cm, leading to an extraordinary enhancement in electron mobility and consequently, an average power factor of 37 W cm⁻¹ K⁻² in the Nb-doped TiCoSb single-crystal.

Gastrointestinal stromal tumours (GISTs) are clinically heterogeneous, with varying degrees of aggressiveness. Here, the authors describe the genomic and transcriptomic landscape of 117 GISTs from 105 patients; they find four molecular subtypes as well as recurrent inactivating YLPM1 mutations in high-risk/metastatic GIST.

CaV1.2 is crucial in cardiac, vascular and neuronal function, serving as a target for many drugs. Here, authors identify the binding site of herb-derived drug tetrandrine, and explore inhibitory mechanism of L/T-type selective DHP drug benidipine.

Structures of human cholecystokinin receptors in complex with various ligands or G-proteins reveal how different ligand types are recognized and the basis of peptide selectivity in this receptor family, and suggest a stepwise activation mechanism.

The thermoelectric material Mg₃Bi₂ is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

β-Cell dysfunction is a hallmark of type 2 diabetes. Here, the authors show that trimethylamine N-oxide (TMAO (a microbiota metabolite)) induces β-cell dysfunction and type 2 diabetes in mice through NLRP3 inflammasome activation and calcium transients.

Na_V1.3 is involved in neuronal development, hormone secretion and pain perception. Here, the authors elucidate the molecular mechanism for modulation of Na_V1.3 by a site-2 neurotoxin bulleyaconitine A and a subtype selective antagonist ICA121431.

Radiotherapy is the mainstay treatment for nasopharyngeal carcinoma (NPC). Here the authors show that the deubiquitinase, USP44, increases radiosensitivity of NPC cells by promoting the degradation of Ku80, and thus enhancing the levels of DNA damage.

The current use of elastography ultrasound faces challenges, including vulnerability to subjective manipulation, echo signal attenuation, unknown risks of elastic pressure and high imaging hardware cost. Here, the author shows a virtual elastography to empower low-end ultrasound devices with state-of-art elastography function.

Treatments for Alzheimer’s disease (AD) remain limited. Here, the authors show that 40 hertz blue light activates a visual circuit to boost glymphatic drainage, and enhances memory, motivation, and anti-Aβ therapy efficacy in a mouse model of AD.

The pandemic of SARS-CoV-2 post a significant threat to public health. Here the authors show, by screening 23 viral proteins, that both structural and non-structural SARS-CoV-2 proteins are capable of modulating host innate immunity and type interferon responses, with this information serves to warrant further studies on SARS-CoV-2 pathogenesis.

The structural stability is challenging for 1T-MoS2 based catalysts. Here, authors report that p-block In-O atoms stabilize the 1T-MoS2 matrix via interface orbital coupling. In-O also enables epitaxial growth of Ru nanoparticles from the MoS2 lattice, enhancing performance in Li | |O2 batteries.

FREE1/FYVE1, a component of the ESCRT complex, is essential for the biogenesis of multivesicular bodies. A novel function of this protein is shown here—ABA promotes FREE1 nuclear import to downregulate ABA transcriptional downstream responses.

The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.

Neuromedin U receptor 2 is an emerging attractive target for treating obesity. Here, a Cryo-EM structure of NmU-25–NMU2–G_i1 provides the structural basis for the designation of highly selective drugs.

Myocardial infarction (MI) is the most common emergent manifestation of cardiovascular diseases. Here, the authors designed a nanomedicine that can reprogram MI microenvironment by converting the detrimental substances (H+, ROS and hypoxia) into beneficial elements (O2 and H2O), as such demonstrates promising potential for the clinical application.

The cis-peptide bond is rare in natural proteins and its impact on protein folding is elusive. Here the authors break the conventional understanding that cis-amide-favoring residues destabilize proteins, elucidate the principles of peptoid cis-trans isomerization in collagen folding, and showcase the use of cis-amide-favoring residues in building programmable and functional peptidomimetics.

Chemically functionalized graphene oxide-based pn junction diodes have potential for future electronic device applications. Here, the authors report an all carbon pn diode with graphene oxide and carbon nanotubes electrodes showing excellent current rectification and efficient logic gates.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Editing of a rice gene that has a role in phospholipid synthesis has endowed rice plants with broad-spectrum resistance to disease, including protection from common bacterial and fungal pathogens, without decreasing the yield.

The protective role of MAIT cells in the HFRS disease and the ER stress related mechanisms behind MAIT cell pyroptosis during HTNV infection.

Scorpions have maintained the primary anatomical features of their Paleozoic arthropod ancestors. Here, the authors report the genome sequence of Mesobuthus martensiiand highlight evidence of genetic and morphological evolution that represents a unique adaptation model of arthropods.

The early identification of metabolic disorders could improve or prevent overt disease. Here the authors show that the circulating concentration of hyocholic acid (HCA) species is decreased in the context of obesity and diabetes and increased after gastric bypass surgery in humans, and further that serum HCA species are predictive of metabolic outcomes in healthy individuals.

Structures of the glucagon receptor bound to β-arrestin 1 are reported, providing further information about the arrestin-mediated modulation of G protein-coupled receptors.

Partial structures are reported for Ca_v3.1 both on its own and in complex with a phase II drug candidate for seizure and neuropathic pain; this presents the overall architecture of T-type Ca²⁺ channels, insights into their gating and permeation mechanisms, and how they are modulated by small-molecule blockers.