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Haploid embryonic stem cells for cattle and sheep are produced, opening new reproductive possibilities.

Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive disease. Here, the authors identify recurrent somatic mutations of GNAQ in NKTCL, and model how this mutation contributes to NKTCL pathogenesis.

The high trap density associated with tin (II) oxidation impacts the device performance of methylammonium cation-free tin-lead perovskite solar cells. Here, authors employ rubidium acetate for defect passivation and achieve efficient and stable single-junction and all-perovskite tandem solar cells.

Understanding the development of subsolid nodules (SSNs) in lung adenocarcinoma (LUAD) is important for their clinical management. Here, the authors perform proteogenomic analysis of 66 LUAD displayed as SSNs from 3 histological stages and highlight the role of endoplasmic reticulum stress in progression.

Ti-Sb-Te is a promising phase change memory material however its phase transition mechanism is poorly understood. Here, the authors use microscopic and spectroscopic techniques to show that titanium-centered octahedra play a major role in boosting the performance of Ti-Sb-Te based phase change memory.

Dense atomic-scale 2D/2D Schottky heterojunctions are achieved in the graphene-based superlattice nanocomposites by controlled deintercalation, largely facilitating spatial charge separation that optimizes their microwave-absorbing performance.

Single-atom catalysts provide atomic-level control over active sites but often lack orbital-level manipulation. Here the authors demonstrate orbital engineering of a Cu catalyst, achieving control over coordination geometry and high metal loading.

Jin and colleagues show that myeloid cells in patients with colorectal cancer exhibit increased expression of SIRPA and that Sirpa deficiency on macrophages reprograms the tumor microenvironment and enhances the function of antitumor CD8⁺ T cells.

Black phosphorus/molybdenum disulfide heterostructures serve as a building block for logic devices with overall superior performance characteristics.

Through a joint analysis of radial velocity and astrometry, Wang et al. have discovered a putative mass-gap black hole candidate in a wide binary system. Its wide circular orbit challenges current binary evolution and supernova explosion theories.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

The occupied anti-bonding states at the Fermi level in metavalently bonded systems stems from the interplay between metavalent bonds and the phase of orbitals. This provides a recipe for identifying superior dopants to improve the thermoelectric performance of metavalently bonded materials.

Hepatic expression of constitutively active glucagon receptor may have contributed to the glucose and lipid metabolism and the high metabolic rates that enabled the evolution of flight in birds.

Non-fused ring electron acceptors may have low synthetic costs but also exhibit poor crystallinity in organic solar cells. Zeng et al. use a binary solvent system to control the crystallization and phase separation of donor and acceptor materials, achieving over 19% efficiency.

Surgery is an important part of treatment for gastric adenocarcinoma, however, the consensus on perioperative care is less clear. Here, the authors report the results of a phase II clinical trial investigating neoadjuvant camrelizumab with concurrent chemoradiotherapy, followed by surgery for the treatment of advanced gastric adenocarcinoma.

In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.

In a breast cancer animal model, long-term exposure to carbon nanotubes promotes tumour invasiveness and metastasis through activation of local and systemic inflammation.

Optical aberrations can hinder fluorescence imaging of thick samples, reducing image signal, contrast, and resolution. Here, the authors introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition or introducing more optics.

Epitaxial growth of heterostructures composed of materials with large lattice mismatch is challenging. Here, the authors reported the epitaxy of II-VI semiconductor nanorods on plasmonic noble metal, despite a lattice mismatch of more than 40%.

The development of highly efficient catalysts for the selective upgrading of biomass remains a huge challenge. Here, the authors report a Cu single-atom catalyst that facilitates the solar-driven synthesis of renewable chemicals from lignocellulosic biomass and green methanol as a hydrogen donor.

IFIs pose a significant threat to immunocompromised individuals, and there is an urgent need for rapid and sensitive diagnostic assays. Here, the authors present a rapid molecular diagnostic method based on magnetic fungal enrichment and CRISPR-based detection.

A high-performance NO₂ gas sensor based on highly catalytic non-precious metal nitride TiN_x demonstrates excellent selectivity, sensitivity, and long-term stability, making it a leading candidate for environmental monitoring technology.

Long-distance V(D)J recombination is facilitated by contraction of the Igh locus and linear RAG scanning along chromatin, both driven by cohesin-mediated loop extrusion, which allows recombination of widely separated gene segments to occur.

A very uncommon detached binary system with a 20.5-min orbital period has been discovered to harbour a carbon–oxygen white dwarf star and a low-mass subdwarf B star with a seven-Earth radius that traces the theoretical limit of binary evolution predicted 20 years ago.

ISSAAC-seq offers a sensitive and modular tool for joint profiling gene expression and chromatin accessibility in single cells.

Comprehensive profiles of tumour and microenvironment are critical to understand heterogeneity in non-small cell lung cancer (NSCLC). Here, the authors profile 42 late-stage NSCLC patients with single-cell RNA-seq, revealing immune landscapes that are associated with cancer subtype or heterogeneity.

Gao, Nowak-Imialek, Chen et al. generate porcine and human stem cells that possess expanded developmental potency for both embryonic and extra-embryonic cell lineages.

Experiments using DNA barcoding for lineage tracing in mouse models of colorectal cancer reveal polyclonal origins of premalignant lesions, with a transition to monoclonality as they progress to the advanced tumour.

Hydroxyl radicals (OH) determine the tropospheric self-cleansing capacity. This study reveals that reactive aldehyde chemistry plays an important role in OH formation and helps narrow the gap between ambient OH observations and model simulations.

Acquired resistance to cetuximab can be mediated by generation of mutations in the EGFR ectodomain. Here the authors report a structure-guided and phage-assisted evolution approach for cetuximab evolution to reverse resistance without altering the binding epitope or undermining antibody efficacy.

A metallofullerenol nanomaterial, Gd@C₈₂(OH)₂₂, was shown to inhibit growth of several solid cancers in preclinical models and yet exhibit low toxicity. Herein the authors show that Gd@C₈₂(OH)₂₂functions as an inhibitor of breast cancer stem cell function via blocking TGF-β and HIF-1α signalling, while sparing normal tissue.

The sensitivity of Li-ion battery materials to moisture complicates their synthesis, storage, processing and recycling. Here, authors show that protonation causes structural instability in LiNi_xCo_yMn_1-x-yO₂ (0 <x,y < 1) and that controlled H⁺ and Li⁺ concentration in aqueous processing is critical.

Naive T cells are quiescent but undergo dynamic changes upon antigenic activation. Li and colleagues show that upregulation of tRNA methyltransferase complex TRMT61A–TRMT6 and N¹-methyladenosine modification of tRNAs contribute to accelerated mRNA translation efficiency, in particular that of MYC protein, and are required for rapid T cell proliferation.

Nanotechnology has the potential to increase the net revenue from agricultural products and alleviate the environmental impact of conventional fertilizers and pesticides. Further improving the efficiency of nanoformulations is necessary for their wide adoption.

Conventional deoxygenation methods typically result in inevitable trace oxygen residue in organic semiconductors. Here, Huang et al. reports a non-destructive soft-plasma treatment for deoxygenation and that removal of trace oxygen can be used to modulate p-type characteristics.