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The authors achieve high energy storage performance with near-ideal energy conversion efficiency and outstanding temperature stability in the entropy-stabilized ferroelectric ceramics by constructing a temperature-adaptive multiphase coexistence structure.

Targeted multielement substitution of a lead-free relaxor ferroelectric perovskite distorts the lattice structure and induces strong polar disorder, leading to high-polar-entropy ferroelectric oxides with a high electrocaloric effect and long lifetime.

High-voltage sodium solid-state batteries often suffer from capacity loss due to harmful internal reactions. By adding a uniform protective layer to the cathode, this study greatly improves their stability—retaining 77.9% capacity after 1,500 cycles—and shows promise for developing longer-lasting, high-energy batteries.

Zhao et al. report bilateral Geiger mode avalanche in 2D graphene/InSe/Cr asymmetrical Schottky junction. The asymmetrical Schottky junction benefits to initiate impact ionization and multiplication for the injected majority carriers, leading to a multiplication factor up to 10 ^ 7 and a breakdown voltage of 1.4 V.

Graphene-based electrodes are limited by difficulty in controlling the geometry and variability. Here, the authors present a method to construct covalently bonded, uniform, and high-yield graphene-molecule-graphene single-molecule junctions with high stability and atomic precision.

The authors utilize the pulsed electric stimulus near the critical electric field to perform the antiferroelectric-ferroelectric phase transition engineering, realizing enhancement and quick stabilization of capacitance in antiferroelectrics.

The authors report diode-like resistance in a non-magnetic topological insulator in the quantum Hall regime.

This study shows that protein kinase A (PKA) drives bone lesions in fibrous dysplasia and that targeting it in mouse models reduces disease severity, highlighting PKA as a promising therapeutic target for fibrous dysplasia.

Investigation of the reaction process at the single-bond interface is key to understanding the catalytic reaction mechanism. Here, the authors develop a STM-BJ method to monitor the catalytic process from the perspective of single-bond energy.

Nie et al. report a multi-site binding ligand to suppress the formation of defects and increase the structural and water stability of perovskites. Solar cells fabricated fully in air achieves an efficiency of 25.03% and retain 98.98% of the performance after aging in air for 1,584 h without encapsulation.

Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective autophagy machinery.

Conventional silicon-based transistors, which sit at the heart of every computer, are fast approaching the limit of miniaturisation. Here, Meng et al demonstrate a field-effect transistor composed of a single rutheniumdiarylethene molecule with large on/off ratio.

The SEED study is a phase 3 clinical trial demonstrating a beneficial effect on glycemic control of dorzagliatin, a glucokinase activator, in drug-naive patients with newly diagnosed type 2 diabetes.

The selective installation of quaternary carbon substituents on arenes is a highly challenging synthetic goal. Here, the authors report a chromium-catalyzed para-selective functionalization of benzamides with tertiary organometallic reagents under mild conditions.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Clinical diagnosis of temporomandibular joint (TMJ) disorders is complex and requires evaluation by a qualified physician. Here, Yan et al. develop a hydrogel electronic sensor to detect TMJ movement, able to accurately detect and classify disc displacement with reduction, a common TMJ disorder.

The topological surface states usually appear in pairs in a topological insulator, with one on the top surface and the other on the bottom surface. Here, Zhang et al. utilize Co cluster to induce a Zeeman gap on one surface through antiferromagnetic exchange coupling, and observe a quasi-half-integer plateau, suggesting the parity anomaly of Dirac fermions.

Autophagy is initiated by the Unc-51-like kinase protein kinase complex (ULK1C) and class III phosphatidylinositol 3-OH kinase complex I (PI3KC3-C1). Here, the authors reveal the structure of the 2:1:1 core of ULK1C and its complex with PI3KC3-C1. ULK1C transitions to a 2:2:2 complex in the presence of PI3KC3-C1, suggesting a mechanism for autophagy induction.

Prussian blue analogues are promising for aqueous batteries but interstitial water effects remain underexplored. Here, authors develop a cation-self-shielding strategy with dihydroxyacetone to stabilize water-rich Prussian blue analogues for application in K-ion batteries.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Radiotherapy-induced oral mucositis is a common side effect in nasopharyngeal carcinoma treatment. Here, the authors present a phase 3 randomized clinical trial assessing the safety and efficacy of ulinastatin to prevent the incidence and severity of this condition.

Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom. Here, the authors report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity.

Convergence of heavy or light chains in antibodies recognising pathogens could drive mutations in these pathogens. Here the authors examine antibodies against SARS-CoV-2 and find that a conserved VL6-57 light chain recognising a conserved motif in the spike protein is associated with virus mutations and could drive changes in SARS-CoV-2 omicron variants.

Effectiveness of the hepatitis E vaccine HEV 239 amongst high-risk groups isn’t well studied. Here, Zhuang et al. analyse a decade of surveillance data (2007–2017) from Dongtai, China, and estimate HEV 239 effectiveness of 72% amongst hepatitis B virus infected people.

Designing superelastic materials with high critical stress, large recovery strain and temperature-independent modulus is desired but challenging. Here, the authors achieve these properties in a high-entropy alloy with multi-scale heterogeneities.

Generative models rapidly generate many similar molecules but face synthesis challenges. Here, authors introduce an algorithm that leverages reusable synthesis patterns to improve retrosynthetic planning efficiency for such AI-generated molecules.

Amino acid changes in a newly identified spike epitope enabled the Delta variant to evade a population antibody response.

Enhancing the transport properties of surface states in topological insulators is vital if they are to be incorporated into practical devices. Towards this end, Chen et al. study the transport in aged (Cu_0.1Bi_0.9)₂Te_3.06, where the ageing process suppresses bulk conductance by up to four orders of magnitude.

Ferroelectric/antiferroelectric phase boundary is both technologically and scientifically important. Here, the authors reveal the structure of intermediate phase involved in classical Pb(Zr_1-xTi_x)O₃.

Scalable fabrication of coordinatively unsaturated metal-nitrogen is challenging. Here the authors report a general method for synthesize such material for CO2 electrochemical conversion at a high catalytic current of 10 A for more than 60 h stability using a 100 cm2 membrane flow cell.

Transparent wood has potential in building applications, and there is interest in this having additional functionality. Here, the authors report the development of transparent wood with room temperature phosphorescence.

Phase transitions are important in self-assembly process, but multiple, sequential transitions are challenging to achieve. Here, the authors report the development of the formation of wormlike micelles, which change phase following dilution to give gel-sol-gel-sol transitions.

Germline variants that predispose to lung cancer have been mostly studied in Western populations, but data from Chinese patients is lacking. Here the authors analyze lung cancer germline variants in 1794 Chinese patients, finding exclusive variants or with different frequency compared to TCGA data.

The synthesis of benzylic carbocations bearing meta-hydroxyl substituents is difficult due to their lack of resonance stabilization. Now, a catalytic enantioselective reaction between meta-hydroxyl triarylmethanols and indoles, proceeding through a meta-hydroxyl triarylmethyl cation, is reported. A range of chiral tetraarylmethanes with anticancer activity are prepared.

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Single-molecule electrical detections clarify both productive and hidden degenerate pathways of ring-closing metathesis, and enable precise on-device synthesis of a single polymer with single-monomer-insertion-event resolution.

Millimetre-scale meron lattices that are stable at room temperature and under zero magnetic field can be used as spin injectors in light-emitting diodes, providing 22.5% circularly polarized electroluminescence.

Defect engineering of topological materials provides an avenue for the controllable manipulation of optoelectronic properties. Here, the authors introduce a defect gradient into a Dirac semimetal to control the Berry curvature dipole-driven THz emission in the material.

Here, the authors report results from a randomized, placebo-controlled phase 3 trial of the tetravalent SARS-CoV-2 protein vaccine SCTV01E, demonstrating a favorable efficacy profile during a time when predominant viral variants were changing from BA.5 and BF.7 to XBB.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.