OkaE is an αKG-NHFe enzyme capable of synthesizing the pharmacophoric motif azetidine ring via unique C–C bond formation. Here, the authors report the multifunctionality of OkaE, which enables not only azetidine formation but also scaffold diversification through sequential oxidations, including hydroxylation, epoxidation, and ring cleavage.
- Xinye Wang
- Junjie Yu
- Xueting Liu