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Author Correction: Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering

Marshall S. Padilla
Kaitlin Mrksich
Michael J. Mitchell
Amendments and CorrectionsOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1
Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

Ningqiang Gong
Dongyoon Kim
Michael J. Mitchell
Amendments and Corrections31 Jul 2025
Nature Biomedical Engineering

P: 1
Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

The combinatorial synthesis of ionizable lipids allows for the identification of an antioxidant lipid exhibiting low immunogenicity for lipid nanoparticle-mediated mRNA delivery in vivo.

Ningqiang Gong
Dongyoon Kim
Michael J. Mitchell
Research18 Jul 2025
Nature Biomedical Engineering

P: 1-15
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo

A class of cationic—amidine-based degradable—lipids can now be readily synthesized through a tandem multi-component amine–thiol–acrylate conjugation reaction. Mechanistic studies provided key insights, from which the observed lead lipid enabled mRNA delivery to multiple organs, highlighting the potential for developing mRNA vaccines and therapeutics to treat various diseases.

Xuexiang Han
Mohamad-Gabriel Alameh
Michael J. Mitchell
Research09 Jul 2024
Nature Chemistry

Volume: 16, P: 1687-1697
CD59 Silencing via Retrovirus-Mediated RNA Interference Enhanced Complement-Mediated Cell Damage in Ovary Cancer

Xuexiang Shi
Bei Zhang
Meihua Gao
Research01 Feb 2009
Cellular & Molecular Immunology

Volume: 6, P: 61-66
Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering

Lipid nanoparticles (LNPs) are the preeminent drug delivery vehicle for mRNA therapies, partially due to the ionizable lipid (IL) components that facilitate endosomal escape. Here, authors devise terminally branched ILs that enhance endosome escape, resulting in increased liver and T cell delivery.

Marshall S. Padilla
Kaitlin Mrksich
Michael J. Mitchell
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery

mRNA delivery through LNPs targeting specific organs holds great clinical potential, but it remains unclear how the structure of the lipidoids in the LNPs controls organ tropism. Here the authors direct in vivo delivery of siloxane-based LNPs via structural alteration of the ionizable structure of the constituting lipidoids.

Lulu Xue
Gan Zhao
Michael J. Mitchell
Research01 Oct 2024
Nature Nanotechnology

Volume: 20, P: 132-143
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders and women’s health.

Kelsey L. Swingle
Alex G. Hamilton
Michael J. Mitchell
Research11 Dec 2024
Nature

Volume: 637, P: 412-421
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models

Identifying pulmonary delivery of lipid libraries poses an obstacle for mRNA drugs. Here, the authors use a barcoded screening system to identify lung-targeting of cationic, degradable lipid-like materials for mRNA delivery and gene editing in female preclinical models.

Lulu Xue
Alex G. Hamilton
Michael J. Mitchell
ResearchOpen Access29 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

Cancer cell-derived small extracellular vesicles bind to therapeutic nanoparticles leading them from tumours to the liver for degradation. This mechanism is another barrier for the development of efficient nanoparticle-based cancer therapies.

Ningqiang Gong
Wenqun Zhong
Michael J. Mitchell
Research02 Sept 2024
Nature Materials

Volume: 23, P: 1736-1747
Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Outer membrane vesicles (OMVs), non-replicative particles secreted by Gram-negative bacteria, are known for their immunostimulatory and adjuvant properties. Here, by employing a Plug-and-Display technology, the authors engineer OMVs to display tumor antigens on the surface, a platform that promotes anti-tumor immune responses in preclinical cancer models.

Keman Cheng
Ruifang Zhao
Guangjun Nie
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-16
Responsive and activable nanomedicines for remodeling the tumor microenvironment

This article includes two protocols for the construction of responsive and activable nanomedicines that regulate the tumor microenvironment.

Yinlong Zhang
Xuexiang Han
Guangjun Nie
Protocols11 Dec 2020
Nature Protocols

Volume: 16, P: 405-430
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreatic cancer treatment.

Xuexiang Han
Yiye Li
Guangjun Nie
ResearchOpen Access23 Aug 2018
Nature Communications

Volume: 9, P: 1-18
A Biochemiluminescent Sialidase Assay for Diagnosis of Bacterial Vaginosis

Shengjun Wu
Xuexiang Lin
X. James Li
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
A rapid influenza diagnostic test based on detection of viral neuraminidase activity

Xuexiang Lin
Xiao-Yu Liu
X. James Li
ResearchOpen Access11 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
High-precision monitoring and prediction of mining area surface subsidence using SBAS-InSAR and CNN-BiGRU-attention model

Mingfei Zhu
Xuexiang Yu
Wenjiang Long
ResearchOpen Access22 Nov 2024
Scientific Reports

Volume: 14, P: 1-18
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease

Baihui Cao
Xiaotong Chen
Yan Li
ResearchOpen Access06 Aug 2024
npj Parkinson's Disease

Volume: 10, P: 1-14
Gene expression related to trehalose metabolism and its effect on Volvariella volvacea under low temperature stress

Xu Zhao
Xiaoxia Song
Mingjie Chen
ResearchOpen Access20 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells

Ying Yu
Bing Liu
Yifei Xing
ResearchOpen Access10 Jan 2022
Cell Death & Disease

Volume: 13, P: 1-13
Preparation and bacteriostatic research of porous polyvinyl alcohol / biochar / nanosilver polymer gel for drinking water treatment

Hang Zhao
Xuexiang Li
Juanqin Xue
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-11
CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect

Mingyue Liu
Xu Wang
Pan Zheng
ResearchOpen Access15 Jul 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-3
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4

Lulin Cheng
Qingliu He
Yifei Xing
ResearchOpen Access31 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-14
KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer

Dingheng Lu
Yarong Song
Yifei Xing
ResearchOpen Access12 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-13
Development and validation of deep learning algorithms for scoliosis screening using back images

Junlin Yang et al. develop deep learning algorithms that diagnose adolescent idiopathic scoliosis with its accuracy superior to human specialists. This method reduces patients’ exposure to radiation and unnecessary referrals when used for routine scoliosis screening and periodic follow-ups.

Junlin Yang
Kai Zhang
Haotian Lin
ResearchOpen Access25 Oct 2019
Communications Biology

Volume: 2, P: 1-8
Selection for Oil Content During Soybean Domestication Revealed by X-Ray Tomography of Ancient Beans

Yunbing Zong
Shengkun Yao
Huaidong Jiang
ResearchOpen Access27 Feb 2017
Scientific Reports

Volume: 7, P: 1-10

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Author Correction: Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering

Author Correction: Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity

Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo

CD59 Silencing via Retrovirus-Mediated RNA Interference Enhanced Complement-Mediated Cell Damage in Ovary Cancer

Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering

Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models

Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Responsive and activable nanomedicines for remodeling the tumor microenvironment

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

A Biochemiluminescent Sialidase Assay for Diagnosis of Bacterial Vaginosis

A rapid influenza diagnostic test based on detection of viral neuraminidase activity

High-precision monitoring and prediction of mining area surface subsidence using SBAS-InSAR and CNN-BiGRU-attention model

PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease

Gene expression related to trehalose metabolism and its effect on Volvariella volvacea under low temperature stress

ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells

Preparation and bacteriostatic research of porous polyvinyl alcohol / biochar / nanosilver polymer gel for drinking water treatment

CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4

KAT2A-mediated AR translocation into nucleus promotes abiraterone-resistance in castration-resistant prostate cancer

Development and validation of deep learning algorithms for scoliosis screening using back images

Selection for Oil Content During Soybean Domestication Revealed by X-Ray Tomography of Ancient Beans

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