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Epithelial organoids are grown without Matrigel using a single-chain antibody.

Hole spin semiconductor qubits suffer from charge noise, but now it has been demonstrated that placing them in an appropriately oriented magnetic field can suppress this noise and improve qubit performance.

Manipulating topological spin textures are demanded for future spintronic devices, but knowledge about phase transitions among different spin textures remain limited. Here, Fujishiro and Kanazawa et al. report chemical-pressure-controlled phase transitions between different topological spin textures in chiral magnets MnSi_1−xGe_x.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin chain is recognized by the human 26S proteasome, revealing a multivalent binding mode that underlies selective recognition.

The influence of an animal’s running speed on grid cell spatial representation is unclear. Here, the authors present a Gaussian Process with Kernel Regression method to infer neural representational geometry from data and show that faster movement dilates grid cell representational manifolds, enhancing spatial representation.

Cyclopentadienyl ligands are central to organometallic lanthanide chemistry as their electron-donating ability enables fine-tuning for various applications including catalysis, luminescent materials, and single molecule magnets. Here, the authors report the synthesis and characterization of the lanthanide complexes featuring η⁵-coordinating heterocyclic stibolyl and bismolyl ligands.

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.

The prevalence of Alzheimer’s disease neuropathological changes is reported based on blood-based biomarkers in a Norwegian population-based cohort.

Single-cell proteomics by data-independent acquisition (DIA) mass spectrometry is growing, but data analysis approaches vary widely. Here, authors benchmark and recommend optimal strategies for analyzing DIA-based single-cell proteomics data.

Rapid proton capture nucleosynthesis stalls at waiting-point nuclides, including ⁶⁴Ge. Precision mass measurements in the vicinity of this nuclide influence state-of-the-art calculations of X-ray bursts from accreting neutron stars.

The authors report on a method for precise control of stoichiometry and surface termination during thin-film growth of a wide range of perovskite ABO₃ phases that exploits dynamic B-site layer inversion seen in the in situ electron diffraction.

Researchers find that whether a person is first vaccinated or first infected with COVID-19 influences their antibody and T-cell responses, offering new insights into how hybrid immunity develops and protects over time.

Brain age gaps (BAGs) highlight deviations from healthy brain aging, yet their biophysical underpinnings in aging and dementia are not well understood. Here, the authors use EEG connectivity and generative modeling across diverse populations to reveal that BAGs are influenced by geography, income, sex and education, with implications for understanding accelerated aging and dementia.

Van der Waals structures provide a new platform to explore novel physics of superconductor/ferromagnet interfaces. Here, NbSe₂ Josephson junction with Cr₂Ge₂Te₆ enables non-trivial Josephson phase by spin-dependent interaction, boosting the study of superconducting states with spin-orbit coupling and phase-controlled quantum electronic device.

Piezoelectric coupling of a single superconducting qubit to two phononic crystal nanoresonators results in an integrated device that is able to control and read out the quantum state of the two mechanical resonators.

Wearable sensors typically require innovative methods of energy harvesting for low-power electronics. Here, the authors present an adaptive power management system with a trimodal energy harvesting approach.

Loophole-free violations of Bell inequalities imply that at least one of the assumptions formalising local hidden-variable theories must fail. Here, the authors show that, if only one is false, then it has to fail completely, therefore excluding models that allow partial instantaneous actions at a distance, partially constrain freedom of choice or allow for partial retrocausal influences.

CNS toxicity was unexpectedly observed for anti-miR-17 RGLS4326 in nonclinical studies. Here, authors identify AMPA receptor inhibition as the likely culprit. Replacement of 3’-terminus guanine to adenine leads to discovery of farabursen (RGLS8429) that is devoid of CNS toxicity.

Mounier et al., analyse whether obesity, measured by body mass index (BMI) affects the shared genetic risk between 71 long-term health conditions including diabetes, heart disease and arthritis. Health interventions that help to lower BMI can reduce multimorbidity and promote longer and healthier lives.

Device-independent quantum key distribution aims at the ultimate quantum-based unconditional security, but current protocols’ rates are quite far from anything practical. The authors’ protocol narrows this gap by using two randomly chosen key generating bases instead of one.

Patient-level external control data from prior clinical studies or electronic health records can be used in the design and analysis of clinical trials. Here the authors report a hybrid trial design combining the use of external control data and randomization to test experimental treatments, using small cell lung cancer and glioblastoma datasets as examples.

Authors show that all individuals have asymmetrically glycosylated IgGs—the glycans on each of the Fc protomers are not identical. Asymmetrically monofucosylated IgGs drive dengue disease and are functionally similar to afucosylated IgGs.

Understanding global methane trends remains limited, especially from a consumption view. This study shows rising emissions, limited decoupling, and shifting trade patterns involving more emerging and developing economies.

Polaritonic Fourier crystal provides harmonic modulation of the polariton momentum in a pristine polaritonic waveguide. Authors employ hexagonal boron nitride and near-field imaging to probe Bloch waves of phonon-polaritons in the Fourier crystal.

Hole-spin qubits based on semiconductor quantum dots offer potential advantages over their electron-spin counterparts, such as fast qubit control and enhanced coherence times. Liles et al. report a hole-based singlet-triplet spin qubit in planar Si MOS device and develop a model to describe its dynamics.

The study shows that DNA double-strand break repair follows a circadian rhythm: homologous recombination peaks in the morning and declines by evening. CRY1 regulates CCAR2 to modulate this cycle, linking daily timing to genomic stability and cancer therapy response.

Kidney organoids derived from human pluripotent stem cells are infused in a normothermic machine perfusion system to condition explanted porcine kidneys, and the feasibility and viability of their in vivo engraftment are demonstrated.

How genetic information in the germinal zone determines neuronal cell types is unclear. Here the authors show that MEIS2 plays an important role in determining GABAergic neuron diversity during development.

The worldwide distribution and water supply of water towers (snowy or glacierized mountain ranges) is indexed, showing that the most important water towers are also the most vulnerable to socio-economic and climate-change stresses, with huge potential negative impacts on populations downstream.

The interplay between magnetism and charge density wave in the kagome magnet FeGe is under debate. By using elastic and inelastic X-ray scattering, angle-resolved photoemission spectroscopy, and first principles calculations, Miao et al. propose that the charge density wave is stabilized by spin-phonon coupling.

Magnetically intercalated transition metal dichalcogenides provide a platform to study the interplay of magnetism, electronic band structures, and correlations. Here the authors demonstrate a nearly magnetization-free anomalous Hall effect, collinear antiferromagnetism and non-Fermi liquid behavior in V_1/3NbS₂.

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

In most van der Waals ferromagnets, reducing the number of layers reduces the Curie temperature. Here, Chuang et al., find that Cr₂Se₃ has an increased Curie temperature for thinner samples, and through angle-resolved photoemission spectroscopy they attribute this to differences in the valley carrier density in different thickness samples.

Hund’s exchange interaction energy in two-dimensional materials is challenging to extract from experiments. Now, this is achieved in rhombohedral graphene, which allows an estimate of the interactions that drive the variety of correlated states in this material.

Little is known about the molecular pathway to monomers of semiconductor nanocrystals. Here, the authors report a general reaction pathway based on hydrogen-mediated ligand loss for the precursor conversion to ‘monomers’ at low temperature prior to nucleation, via ³¹P NMR spectroscopic measurements.

Radical Fe^II/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

The Majorana Demonstrator experiment reports searches for the violation of the Pauli exclusion principle and of charge conservation. In the absence of a signal, exclusion limits for these processes are reported.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safety of gene editing.

Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci and possible risk mechanisms.

Here, the authors introduce optical phase change materials based on Ge-Sb-Se-Te which breaks the coupling between refractive index and optical loss allowing low-loss performance benefits. They demonstrate low losses in nonvolatile photonic circuits and electrical pixelated switching have been demonstrated.

Here, the authors perform genome-wide mapping of DNA methylation and expression quantitative trait loci, revealing associations among genotype, epigenome and transcriptome, uncovering genes and gene-environment interactions contributing to age-related macular degeneration (AMD).