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Charge transport and extraction in polycrystalline perovskite films are often hindered by inefficient carrier transfer across grain domain boundaries (GDBs). Here, authors employ supramolecular assisted Rb+ delivery for in-situ GDB bridging, achieving efficiency of 26.02% for perovskite solar cells.

The authors show that prenatal propylparaben exposure causes transgenerational inheritance of diminished ovarian reserve via Rhobtb1 hypomethylation, with similar patterns in patient samples. Methyl-donor diet counteracts this, suggesting therapeutic potential.

In a phase 1/2 trial in patients with advanced non-small-cell lung cancer (NSCLC), followed by a phase 2 trial in an EGFR-mutant selected population, treatment with the TROP2-targeting antibody–drug conjugate sacituzumab tirumotecan led to encouraging clinical response rates, especially in patients with EGFR-mutant NSCLC, which was supported by mechanistic data.

Neutrophil extracellular traps (NETs) contribute to heart damage after acute myocardial infarction (AMI). Here, the authors show that S100A12 promotes NETs formation and worsens injury, whereas blocking its interaction with ANXA5 reduces damage, suggesting a new therapeutic target for AMI.

ALOX5 contributes to the tubular injury in IRI-induced AKI through enhancing ferroptosis in the renal tubular cells and might be a novel target for the prevention and treatment of IRI-induced AKI.

The proportion of female cardiologists is increasing in China, and they have special roles in clinical management and research. As the president of the Chinese Society of Cardiology, I believe female cardiologists excel in finding ways to balance family life with their career goals when they receive adequate support.

The limited solubility, inherent chemical stability, and low reactivity of inorganic phosphates pose hinder their conversion into organophosphates under mild conditions. Here, the authors report a method for the direct conversion of phosphates into P(V)-X reagents via a redox-neutral halogenation process, using cyanuric chloride or cyanuric fluoride as the halogenation reagent.

Aluminum stress triggers distinct Ca²⁺ signals in Arabidopsis roots, activating the kinase CPK28. CPK28 phosphorylates STOP1 at Ser163, promoting its nuclear localization and stability, thereby enhancing aluminum resistance in the plant.

Ferroelectrics, which exhibit excellent charge separation ability, suffer from poor photocatalytic activity. The authors unveil the limitations in charge extraction and offer strategies to design high-performance photocatalysts by eliminating surface defects.

Hong, Li and colleagues unveil a pivotal role of TET2 in heterochromatin relocalization, aberrant upregulation of endogenous retroviruses and overactivated innate immune response in hematopoietic stem and progenitor cells during aging.

Elucidation of drought tolerance mechanism would help to develop tolerant crops. Here, the authors reveal the interaction between BBX18, a zinc finger transcription factor, and ascorbate peroxidase (APX1) to mediate drought stress resistance in tomato.

To optimize the interfacial quality and electrode magnetism in spintronic devices, the authors develop an electrode transfer technique that can greatly improve device interfacial quality, performance and reproducibility, universal to various spacers.

This study uncovers a unique broad neutralization mechanism against rotavirus, where antibody 7H13 destabilizes the partial structure of the viral VP4 spike by acting on a critical residue switch located at the interface of multiple VP4 subunits.

The sperm flagellum is composed of tubulin-based microtubules and is critical for sperm motility and thus male fertility. Here, the authors show that STYXL1 regulates CCT complex-facilitated tubulin folding and is essential for sperm flagella formation.

Hu et al. study the role of hexokinase 2 in microglial metabolism and function, and show its dual role under physiological and pathological conditions in a mouse model of stroke-induced neuroinflammation

Inspired by the idea of mimicking virus entry to host cells and macrophage-mediated virus clearance, the authors developed a lysosomal “TRAP”, which could efficiently capture, internalize, and degrade viruses and variants.

Individual antibodies identified in the blood of people triple-vaccinated against SARS-CoV-2 predominantly bind spike protein and are highly effective at neutralizing SARS-CoV-2 variants, including Omicron (B.1.1.529).

The SARS-CoV-2 Delta variant has spread rapidly worldwide. Here, the authors characterise a single chain of transmission of Delta in China, and find evidence that it is more infectious and replicates faster during early infection compared to early pandemic lineages.

Optogenetics makes use of light-sensitive proteins to control biological processes using light. Here, the authors present an optogenetic system that regulates the cGAS/STING pathway remotely and demonstrate its efficacy in murine tumour models.

The hydrogen evolution and oxidation reactions on Pt electrocatalysts exhibit much more favourable kinetics in acidic than in alkaline electrolytes. Now, by combining theoretical simulations and spectroscopic measurements, it is demonstrated that the different connectivity of hydrogen-bond networks in the electric double layer is responsible for such an effect.

Guo, Hong et al. report that TET2 condensation maintains proper DNA demethylation at specific genomic loci, which can be targeted to alter gene expression and impair leukaemia growth.

Intra-cell line heterogeneity remains to be characterized. Here, the use of single multi-omics on a large panel of human cell lines identifies copy number variation, epigenetic variation and extrachromosomal DNA distribution as the main contributors to intra-cell line heterogeneity.

The selective degradation of mitochondria by autophagy is essential for cell homeostasis. Here, Nan et al show that the effector protein BipD, secreted by Burkholderia pseudomallei, is able to modulate host mitophagy to promote its survival.

A subcutaneously injected hydrogel conjugated with antibodies for interleukin-6 substantially reduces the levels of the cytokine during chimaeric antigen receptor T-cell therapy while maintaining its antitumour efficacy.

The utility of microfluidic devices has been limited by several drawbacks including low resolution, inferior feature fidelity, poor repeatability. Here the authors address these challenges by developing a strategic approach of image guided in-situ maskless lithography to fabricate a variety of microfluidic devices and resolve critical proximity effect and size limitations in rapid prototyping.

Oxidative stress triggers lipid accumulation in cells by sequestering triglycerides in lipid droplets. Here, the authors show that lipopolysaccharide-binding protein interacts with redox sensor PRDX4 to control lipid-redox balance and promotes triglyceride accumulation in droplets by capturing unsaturated lipids.

Immunological adjuvants are a crucial component of cancer vaccines. Here the authors design a light-activable immunological adjuvant, based on hypoxia-responsive amphiphilic dendrimer nanoparticles loaded with a photodynamic agent, promoting anti-tumor immune responses in preclinical cancer models.

Neural circuit mechanisms underlying prevention of hyperarousal in acute stress conditions are not fully understood. Here authors show GAD2-positive GABAergic neurons in the midbrain dorsal raphe nucleus constrain the increase of wakefulness to prevent hyperarousal in a mouse model of stress.

In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase neutralization breadth against virus variants.

The electrochemical oxygen reduction reaction plays an important role in new energy technologies such as fuel cells and metal-air batteries. Here the authors present a cobalt catalyst with a symmetry-broken Cl−Co−N₄ moiety capable of dynamically modulating electron occupancy at active sites during practical reaction conditions to optimize oxygen reduction performance.

An inhalable, single-dose dry powder aerosol SARS-CoV-2 vaccine shows good storage stability, results in sustained antigen delivery to antigen-presenting cells in the lungs and induces a potent antiviral immune response.

SARS-CoV-2 infection has been shown to drive NLRP3 inflammasome activation and thereby cytokine storm, but how it does so is unclear. Here the authors show that the viral N protein can bind to NLRP3, resulting in enhanced interaction with ASC and thereby with the NLRP3 inflammasome.

A shape-changing pH-responsive cancer vaccine delivers antigenic peptides directly to the cytoplasm and boosts the cellular immune response upon activation of the inflammasome pathway, efficiently inhibiting tumour growth and extending survival in animal tumour models.

Understanding the in vivo biotransformation of nanomaterials used for biomedical applications might shed light on their long-term effects and safety. Here the authors show that molybdenum derived from nanomaterials is mainly transported in the liver, in a corona-mediated process, and is incorporated in molybdoenzymes, with an effect on liver metabolism.

Cancer vaccines that self-assemble into uniform nanoparticles improve tumor clearance.

Atomically dispersed gold supported by carbon dots amplifies mitochondrial oxidative stress, and leads to irreversible cell damage, inhibiting hepatocellular carcinoma in animal models.